The Ancestral Populations Network Phenotypic Harmonization Working Group Administrative Supplement: LATINO Study

祖先群体网络表型协调工作组行政补充：拉丁裔研究

• 批准号: 10814671
• 负责人: ERIC A. STORCH
• 金额: $ 12.02万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-17 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10814671
• 关键词: Acceleration; Administrative Supplement; African ancestry; Anhedonia; Asian; Cognition; Communities; Consensus; Country; Data; Data Analyses; Data Analytics; Data Collection; Deposition; Diagnosis; Discrimination; Environmental Risk Factor; Equity; Future; Genetic; Genomics; Goals; Healthcare Systems; Individual; Latin American; Latinx population; Measurement; Measures; Mental Health; Mental disorders; National Institute of Mental Health; Obsessive compulsive behavior; Obsessive-Compulsive Disorder; Phenotype; Population; Population Heterogeneity; Procedures; Process; Property; Psychometrics; Reproducibility; Resources; Risk; Site; Standardization; Symptoms; Underrepresented Populations; cognitive function; cohort; data archive; disease phenotype; instrument; member; phenotypic data; psychogenetics; social stigma; suicidal; trait; working group

PROJECT SUMMARY This project actualizes a primary goal of the Ancestral Populations Network (APN; PAR-20-026 and PAR-20- 027), namely to facilitate measurement and data analytic harmonization efforts across APN members to enhance rigor and reproducibility and generate a resource for network members and the scientific community. Through a consensus process of APN members, measures of anhedonia, cognition, obsessive-compulsive symptoms, suicidality, and discrimination/stigma were selected for harmonization across ongoing studies. These harmonized measures will be collected across an estimated 27,500 individuals representing Asian, Latin American, and African ancestries spanning over 15 countries. SUMMARY AND CONNECTION BETWEEN THE APN AND THIS SUPPLEMENT The Ancestral Populations Network (APN) was established by the National Institutes of Mental Health (PAR-20- 026 and PAR-20-027) with overarching goals of (a) accelerating genetic discovery for psychiatric disorders in cohorts of non-European ancestry, (b) advancing global mental health discovery and equity, and (c) facilitating measure and data analytic harmonization efforts across members to enhance rigor and reproducibility and generate a resource for network members and the scientific community. This supplement will implement validated measures of anhedonia, cognition, obsessive-compulsive symptoms, suicidality, and discrimination/stigma across ongoing studies within the APN. These harmonized measures will be collected across an estimated 27,500 individuals representing Asian, Latin American, and African ancestries spanning over 15 countries.

项目概要 该项目实现了祖先种群网络（APN；PAR-20-026 和 PAR-20- 027），即促进 APN 成员之间的测量和数据分析协调工作，以增强 严谨性和可重复性，并为网络成员和科学界提供资源。通过一个 APN成员的共识过程，快感缺乏、认知、强迫症状的测量， 选择自杀和歧视/耻辱来协调正在进行的研究。这些 将针对代表亚洲、拉丁裔的约 27,500 名个人收集统一措施 拥有美国和非洲血统，横跨 15 个国家。 APN 与本补充文件之间的摘要和联系 祖先群体网络 (APN) 由美国国立心理健康研究所 (PAR-20- 026 和 PAR-20-027），总体目标是 (a) 加速精神疾病的基因发现 非欧洲血统群体，(b) 推进全球心理健康发现和公平，以及 (c) 促进 成员之间的测量和数据分析协调工作，以提高严谨性和可重复性 为网络成员和科学界提供资源。本次增补将实施 经验证的快感缺乏、认知、强迫症状、自杀倾向和 APN 内正在进行的研究中存在歧视/耻辱。这些统一措施将被收集 估计有 27,500 名代表亚洲、拉丁美洲和非洲血统的人 超过 15 个国家。