Preparing for Implementation of the ATN CARES Evidence-Based Intervention Package for PrEP Uptake and Syndemic Factors among Youth

准备实施针对青少年 PrEP 吸收和流行病因素的 ATN CARES 循证干预方案

• 批准号: 10818271
• 负责人: Steven J Shoptaw
• 金额: $ 23.52万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10818271
• 关键词: AIDS prevention; Acceleration; Address; Adherence; Adopted; Adoption; African American; Age; Behavior Therapy; Black race; California; Caring; Case Manager; Client; Clinic; Collaborations; Communities; Community Health Aides; Complex; Consolidated Framework for Implementation Research; Data Analyses; Data Collection; Dedications; Development; Diffuse; Dissemination and Implementation; Economics; Effectiveness of Interventions; Elements; Epidemic; Evidence based intervention; Evidence based practice; Failure; Food; Foundations; Frontline worker; Future; HIV; HIV risk; HIV-infected adolescents; Health; Health Educators; Housing; Human Resources; Hybrids; Internet; Intervention; Interview; Latinx; Libraries; Link; Literature; Los Angeles; Manuals; Measures; Medicine; Mental Health; Methods; Minor; Modality; Monitor; Outcome Measure; Pathway interactions; Persons; Phase; Policies; Preparation; Prevention; Protocols documentation; Provider; Public Health; Quality of life; Randomized; Reduce health disparities; Research; Research Project Grants; Risk; Role; Service delivery model; Services; Sexual Health; Sexual and Gender Minorities; Sexual and Gender Minority Youth; Sexually Transmitted Diseases; Slide; Social Behavior; Structure; Surveys; System; Technology; Testing; Text Messaging; Training; Update; Viral; Youth; acceptability and feasibility; aged; automated text message; chatbot; children of color; community engagement; cost; design; effectiveness trial; effectiveness/implementation study; effectiveness/implementation trial; ethnic minority; flexibility; follow-up; high risk; implementation design; implementation intervention; implementation measures; implementation outcomes; implementation research; implementation science; implementation strategy; implementation study; infection risk; innovation; interest; minority children; peer; peer support; pre-exposure prophylaxis; preference; prevent; preventive intervention; programs; racial minority; scale up; service engagement; social; social determinants; staff intervention; substance use; syndemic; telehealth; theories; therapy design; uptake

Project Summary/Abstract America’s increasing HIV epidemic among youth aged 12-24 and our concurrent failure to identify, link to care, sustain support services and achieve viral suppression among youth living with HIV suggests the need to scale-up and sustain community-based strategies to leverage gateways and settings where high risk and infected youth can be engaged in HIV prevention and treatment. Sexual and gender minority and racial/ethnic minority youth in the U.S. are at disproportionate risk of acquiring HIV due to syndemic factors and low PrEP uptake, yet effective and scalable interventions for youths remain limited. This study will accelerate the implementation of Adolescent HIV Medicine Trials Network (ATN) Protocol 149 Optimizing the HIV Prevention Continuum for Youth intervention package that was developed to be responsive to the needs and preferences of implementers and youth. This study proposes to develop with community partners implementation support strategies to prepare for a hybrid type-2 effectiveness-implementation study to test implementation strategies and validate intervention effectiveness in a real-world replication study. Phase 1 Qualitative Interviews and Networking. Interested parties (stakeholders) from Southern California public health and frontline HIV prevention organizations will be interviewed, including agency leaders (n=10) and frontline prevention workers (n=30). The Consolidated Framework for Implementation Research (CFIR) will guide semi-structured interviews and rapid qualitative data analyses for exploring qualitatively the barriers, facilitators, preferences, and opportunities for implementation of the ATN 149 interventions for two primary strategies: 1) agency staff training and delivery by frontline workers; or 2) direct-to-youth delivery by dedicated program staff with reciprocal agency linkages. Phase 2: Intervention Package Update & Type 2 Hybrid Implementation-Effectiveness Trial Preparation: Phase 1 will inform a plan for updating and adapting the intervention package based on one or both implementation strategies. Implementing partners from Phase 1 will be engaged in collaboratively adapting and updating protocols, training materials, text- message libraries, peer support forum, and the mobile-web intervention management system for text-messaging and coaching implementation support.

项目概要/摘要 美国 12 至 24 岁青少年中艾滋病毒流行率不断上升，而我们同时未能采取措施 识别、联系护理、维持支持服务并在青少年中实现病毒抑制 艾滋病毒感染表明需要扩大和维持基于社区的战略，以利用 高风险和受感染青少年可以参与艾滋病毒预防的门户和环境 美国的性少数和性别少数以及种族/族裔青少年处于 由于综合症因素和 PrEP 摄取率低，感染 HIV 的风险不成比例，但 针对青少年的有效且可扩展的干预措施仍然有限。这项研究将加速这一进程。 实施青少年艾滋病毒药物试验网络 (ATN) 协议 149 为响应性而制定的青年艾滋病毒预防连续体干预方案 本研究建议与实施者和青年一起发展。 社区合作伙伴实施支持战略，为混合 2 型做好准备 有效性实施研究，以测试实施策略并验证干预措施 现实世界复制研究的有效性。 第一阶段定性访谈和网络感兴趣的各方（利益相关者）。 南加州公共卫生和一线艾滋病毒预防组织将接受采访， 包括机构领导 (n=10) 和一线预防工作者 (n=30)。 实施研究框架（CFIR）将指导半结构化访谈和快速访谈 定性数据分析，用于定性探索障碍、促进因素、偏好和 实施 ATN 149 干预措施的机会有两个主要策略：1) 机构工作人员培训和由一线工作人员提供；或 2) 由专门人员直接向青少年提供 具有互惠机构联系的计划工作人员。 第 2 阶段：干预方案更新和 2 类混合实施有效性 试验准备：第一阶段将制定更新和调整干预措施的计划 基于第一阶段的一项或两项实施战略的一揽子计划。 将参与协作调整和更新协议、培训材料、文本 消息库、同行支持论坛和移动网络干预管理系统 用于短信和指导实施支持。