The impact of concussive and sub-concussive blows on brain network activity

震荡和亚震荡打击对大脑网络活动的影响

• 批准号: 8431889
• 负责人: Steven P. Broglio
• 金额: $ 43.5万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-15 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8431889
• 关键词: Acceleration; Adolescent; Algorithms; Analysis of Variance; Athletic; Attention; Brain; Brain Concussion; Categories; Centers for Disease Control and Prevention (U.S.); Cerebrum; Clinical; Clinical Assessment Tool; Clinical assessments; Cognitive; Coupled; Decision Making; Diagnosis; Electroencephalogram; Electrophysiology (science); Enrollment; Equilibrium; Evaluation; Event; Exhibits; Frequencies; Functional Magnetic Resonance Imaging; Head; Health; Hour; Impaired cognition; Impairment; Incidence; Individual; Injury; Investigation; Knowledge; Life; Literature; Location; Manufactured football; Measures; Medical; Medical Research; Mentors; Methodology; Michigan; Mission; Neurobehavioral Manifestations; Outcome; Outcome Study; Performance; Play; Prefrontal Cortex; Process; Provider; Publishing; Recovery; Regression Analysis; Reporting; Research; Research Personnel; Research Project Grants; Resources; Risk; Sampling; Science; Seasons; Short-Term Memory; Sports; Students; Symptoms; System; Technology; Telemetry; Testing; Time; Training; Traumatic Brain Injury; Universities; Work; base; biological research; career; cognitive function; college; disorder prevention; high school; insight; motor control; novel; programs; research clinical testing; tool

DESCRIPTION (provided by applicant): Contact sports such as football result in hundreds of blows to the head in athletes each season. Traditional thought has suggested that majority of impacts have no meaningful relationship to cognitive function. Emerging research has suggested that sub-concussive impacts may result in negative changes to brain function. Ultimately, some impacts to the head will result in a concussion. Traditional management of concussions involves the clinical evaluation by a medical provider that is supported with the use of cognitive, balance, and symptom assessments. The injury diagnosis and return to play decision, however, are a subjective process. The highly variable clinical presentation of concussion makes an accurate diagnosis and return to play decision difficult. This problem is coupled with the knowledge that many of the common clinical assessments are not sensitive to post-concussion changes in performance. As such, there is a significant need for more sensitive measure of cognitive functioning. This investigation will implement a novel evaluation of electroencephalogram (EEG) recordings and standard clinical assessments in high school football athletes to evaluate concussive and sub-concussive impacts. Aim 1 will examine how pre, mid, and post-season EEG evaluations relate to the frequency and magnitude of head impacts recorded with the Head Impact Telemetry (HIT) System. Aim 2 will evaluate the relationship between post-concussion performance on EEG and standard clinical tests. The outcomes of this study will provide much needed insight into how sub-concussive impacts influence brain function and how clinical assessment tools relate to more sensitive measures of brain function. In addition, undergraduate and graduate athletic training students will have the opportunity to work on high level research and be mentored on biological research careers. PUBLIC HEALTH RELEVANCE: Commonly implemented clinical assessment tools for sport concussion may not provide the necessary sensitivity for making a safe return to play decision. A new category of impact, the sub-concussive blow, is hypothesized to result in sub-clinical changes undetectable by standard testing methodologies. Novel assessment cerebral electrophysiology may provide more information on brain networks in concussed and sub-concussed athletes. This project will support the NIH's stated mission of extending the healthy life by identifying the effect of concussive and sub-concussive blows on brain networking and their associated life- long consequences.

描述（由申请人提供）：与足球等体育联系，每个赛季都会在运动员的头上受到数百次打击。传统思想表明，大多数影响与认知功能没有有意义的关系。新兴的研究表明，亚困扰的影响可能会导致大脑功能的负面变化。最终，对头部的某些影响会导致脑震荡。脑震荡的传统管理涉及医疗服务提供者的临床评估，并支持认知，平衡和症状评估。但是，伤害诊断并重返决定是一个主观过程。脑震荡的高度可变的临床表现使得准确诊断并恢复决策困难。这个问题与知道许多常见的临床评估对性能后的变化不敏感。因此，非常需要对认知功能进行更敏感的衡量。这项调查将对高中足球运动员的脑电图记录（EEG）记录和标准临床评估进行新的评估，以评估脑震荡和亚置上的影响。 AIM 1将检查季前，中期和季节EEG评估与头部冲击遥测系统（HIT）系统记录的头部影响的频率和幅度如何相关。 AIM 2将评估脑电图后的脑震荡表现与标准临床测试之间的关系。这项研究的结果将提供急需的洞察力，了解亚置上的影响如何影响大脑功能以及临床评估工具如何与更敏感的大脑功能衡量。此外，本科和研究生运动培训的学生将有机会从事高水平研究，并受到生物学研究职业的指导。 公共卫生相关性：针对运动脑震荡的通常实施的临床评估工具可能无法提供必要的敏感性，以确保恢复决策。假设一种新的影响，即亚困扰性打击，导致标准测试方法无法检测到的次链术变化。新颖的评估脑电生理学可能会提供有关脑网络的更多信息，以脑震荡和亚置上的运动员。该项目将支持NIH陈述的使命，即通过确定脑震荡和亚置上的打击对大脑网络及其相关的寿命的影响，延长健康生活。