Epidemiology of Cancer in a Cohort of Older Women

老年女性群体的癌症流行病学

基本信息

批准号：
8066666
负责人：
Kimberly Z Robien
金额：
$ 44.42万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
1985
资助国家：
美国
起止时间：
1985-07-01 至 2015-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8066666
关键词：
Address Age American Ancillary Study Area Body fat Cancer Survivor Cancer Survivorship Censuses Cessation of life Characteristics Cohort Studies Colorectal Cancer Communities Comorbidity Data Data Collection Data Set Data Sources Diet Dietary Factors Disease Division of Cancer Control and Population Sciences Dysmyelopoietic Syndromes Elderly Elderly woman Endometrial Carcinoma Epidemiology Female Funding Future Generations Genetic Research Healthcare Incidence Individual Intervention Investigation Iowa Life Life Style Link Mails Malignant Neoplasms Malignant neoplasm of thyroid Medical Surveillance Modeling Molecular Epidemiology National Cancer Institute Outcome Paraffin Embedding Participant Pattern Peer Review Physical environment Postmenopause Prospective Studies Public Health Publications Publishing Quality of life Questionnaires Registries Reporting Research Research Design Resources Retrieval Risk Risk Factors Rural Developments SEER Program Site Social Characteristics Social Environment Source Surveys Time Tissues United States Centers for Medicare and Medicaid Services United States Dept. of Health and Human Services Universities Woman Women&apos s Health aged base cancer diagnosis cancer epidemiology cancer prevention cancer risk cohort cost cost effective diet and cancer experience follow-up improved indexing interest leukemia malignant breast neoplasm mortality neoplasm registry older women population health programs prospective public health relevance social

项目摘要

DESCRIPTION (provided by applicant): The Iowa Women's Health Study (IWHS) began in 1986 as a longitudinal cohort study to determine whether diet, body fat distribution, and other risk factors were related to cancer incidence among 41,836 post- menopausal women aged 55-69 years. Exposure and lifestyle information was collected in a baseline mailed survey in 1986, and five follow-up surveys in 1987, 1989, 1992, 1997 and 2004. Cancer incidence and mortality have been obtained by annual linkage with the Iowa Cancer Registry (a SEER cancer registry) and the National Death Index since 1986. The project has been extremely productive, with more than 260 research publications published to date. We propose, in this 5-year renewal, to continue to address important questions related to cancer in older women. The cohort is becoming especially informative with regard to less common cancers, and for lifestyle predictors of cancer occurrence and survival among the elderly. We also propose new linkages to sources of community-level data that will allow us to study how an individual's social and physical environment influences their cancer risk. These data sources include the Area Resource File (US Department of Health and Human Services), US Census Data, and data from the Rural Development Initiative Study based at Iowa State University. Our specific aims for the proposed funding period are to: 1) continue to follow the IWHS cohort, who are now 78-92 years old, through a total of 27 years (1986-2012), 2) expand our ongoing investigations of risk factors for incident cancers among women, 3) determine the factors associated with quality of life and mortality among female cancer survivors, and 4) determine the associations between community-level social and environmental characteristics and cancer outcomes and quality of life among elderly women. Continuation of funding for the IWHS is vital not only to completion of the research described in the specific aims, but is also key to supporting existing and several planned ancillary studies. The IWHS is also an active participant in several consortia of cohort studies. The combination of the extensive exposure and follow-up data already collected, linkage with community-level data that will be obtained at no cost, a productive research team, and the important research questions that are proposed make a 5-year continuation of the IWHS an extremely cost-effective means towards improving public health. PUBLIC HEALTH RELEVANCE: With the increasing number of Americans over the age of 65 years, prevention of cancer and its impact in later life is taking on greater importance. Research findings from the Iowa Women's Health Study will continue to add to our understanding of the potentially modifiable factors contributing to cancer prevention and survivorship, and will help public health and health care practitioners prioritize and better utilize health care resources.

描述（由申请人提供）：爱荷华州妇女健康研究 (IWHS) 始于 1986 年，是一项纵向队列研究，旨在确定 41,836 名 55 岁以下绝经后妇女的饮食、身体脂肪分布和其他危险因素是否与癌症发病率相关。 69年。暴露和生活方式信息是在 1986 年的基线邮寄调查和 1987 年、1989 年、1992 年、1997 年和 2004 年的五次后续调查中收集的。癌症发病率和死亡率是通过每年与爱荷华州癌症登记处（SEER 癌症登记处）联系获得的。自 1986 年以来，该项目一直非常富有成效，迄今为止已发表了 260 多篇研究出版物。我们建议，在这个五年更新中，继续解决与老年女性癌症相关的重要问题。该队列在不太常见的癌症以及老年人癌症发生和生存的生活方式预测因素方面变得尤其丰富。我们还提出了与社区级数据来源的新联系，这将使我们能够研究个人的社会和物理环境如何影响其癌症风险。这些数据源包括地区资源文件（美国卫生与公众服务部）、美国人口普查数据以及爱荷华州立大学农村发展倡议研究的数据。我们在拟议资助期间的具体目标是：1) 在总共 27 年（1986-2012）中继续跟踪 IWHS 队列，他们现在年龄为 78-92 岁，2) 扩大我们正在进行的风险因素调查对于女性癌症发病率，3) 确定与女性癌症幸存者的生活质量和死亡率相关的因素，4) 确定社区层面的社会和环境特征与老年人的癌症结果和生活质量之间的关联女性。继续为 IWHS 提供资金不仅对于完成具体目标中描述的研究至关重要，而且对于支持现有的和几项计划的辅助研究也至关重要。 IWHS 也是多个队列研究联盟的积极参与者。广泛的接触和已收集的后续数据、与免费获得的社区级数据的联系、富有成效的研究团队以及提出的重要研究问题相结合，使 IWHS 得以延续 5 年改善公共卫生的一种极具成本效益的手段。公共卫生相关性：随着 65 岁以上的美国人数量不断增加，癌症的预防及其对晚年生活的影响变得越来越重要。爱荷华州妇女健康研究的研究结果将继续加深我们对有助于癌症预防和生存的潜在可改变因素的理解，并将帮助公共卫生和医疗保健从业者优先考虑和更好地利用医疗保健资源。