Randomized comparison of the clinical Outcome of single versus Multiple Arterial grafts: Cognition (ROMA:Cog)
单动脉移植物与多动脉移植物临床结果的随机比较:认知 (ROMA:Cog)
基本信息
- 批准号:10705904
- 负责人:
- 金额:$ 6.25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-06-15 至 2026-06-30
- 项目状态:未结题
- 来源:
- 关键词:AcuteAddressAdultAffectAgeAllelesAmericanApolipoprotein EBiological MarkersBrainBrain EmbolismBrain InfarctionCardiacCardiac Surgery proceduresCerebrumClinicalCognitionCognitiveCoronary Artery BypassCoronary heart diseaseCountryDataDay SurgeryDementiaDiabetes MellitusDiffusion Magnetic Resonance ImagingEarly InterventionEvaluationEventFutureGenotypeGlial Fibrillary Acidic ProteinGoalsImpaired cognitionImpairmentInfarctionInflammationInfrastructureInternationalInterventionLanguageLightMagnetic Resonance ImagingMeasuresMultilingualismNerve DegenerationNeuron-Specific EnolaseNeuronal InjuryOperative Surgical ProceduresOutcomeParticipantPatient CarePatientsPersonsPostoperative PeriodPublic HealthRandomizedRepresentational Oligonucleotide Microarray AnalysisResearchRiskRisk FactorsSamplingScienceScreening procedureSerumShort-Term MemorySiteSpecific qualifier valueStrokeSubgroupSurgeonSurrogate EndpointTechniquesThromboembolismTimeVascular Cognitive ImpairmentWomanacute strokebasebrain healthcognitive functioncognitive performancecognitive testingcohortcomorbiditycomputerizedfollow-upmenmild cognitive impairmentneurofilamentnovelnovel markerpreventprogramsrecruitsextau Proteinstau-1
项目摘要
Coronary heart disease affects over 18.2 million Americans and coronary artery bypass surgery (CABG) is the
most common cardiac surgery in adults. Unfortunately, CABG is associated with stroke, cognitive impairment,
and dementia, especially among women and patients with diabetes. As many as 25% of patients with a clinically
uncomplicated postoperative course have evidence of brain emboli after CABG, and even small infarcts can
unmask latent neurodegeneration and increase postoperative cognitive impairment. Intraoperative
thromboembolism is one of the mechanisms contributing to cognitive impairment, due to surgical aortic
manipulation. Less aortic manipulation is associated with less plaque dislodgement, resulting in fewer embolic
events during cardiac surgery. The Randomized comparison of the clinical Outcome of single versus
Multiple Arterial grafts: Cognition (ROMA:Cog) study will identify both the global impact of CABG surgery
and the impact of acute infarction on cognitive function. The first aim addresses the impact of CABG surgical
technique on long-term cognitive function in an international cohort of 2,000 participants who have been
randomized to either a multiple arterial grafts or single arterial grafts groups and by important subgroups,
including women and patients with diabetes. Results will either demonstrate differences in cognitive function or
provide reassurance to cardiac surgeons that there are no differences in the proportion of patients with cognitive
impairment by surgical technique. In the second and third aims, the short-term impact of CABG surgical
technique will be determined based on domains of cognitive performance, and the associations among CABG
surgical technique, cognitive performance, brain infarction and novel serum biomarkers of brain health in a
cohort of 280 participants. Results will provide us with mechanistic details on the relationships between surgical
technique, detailed cognitive performance, acute MRI indicated brain infarction, and novel biomarkers of brain
health. Leveraging the international ROMA trial infrastructure, one of the largest cardiac surgery trials to date,
we have an unprecedented opportunity to clarify the impact of CABG surgical technique on short and long-term
cognitive function. Preventing postoperative cognitive impairment is an important public health concern that
could be mitigated with specific surgical techniques. The ROMA:Cog study will help to identify people who could
benefit from detailed cognitive evaluation and early interventions, and will establish whether serum biomarkers
can be used as novel surrogate end-points in future studies to prevent vascular cognitive impairment.
冠心病影响着超过 1820 万美国人,冠状动脉搭桥手术 (CABG) 是最有效的治疗方法
成人最常见的心脏手术。不幸的是,CABG 与中风、认知障碍、
和痴呆症,尤其是女性和糖尿病患者。多达 25% 的患者患有临床症状
不复杂的术后病程在CABG后有脑栓塞的证据,甚至小梗塞也可能发生
揭示潜在的神经退行性变并增加术后认知障碍。术中
血栓栓塞是由于主动脉手术导致认知障碍的机制之一
操纵。较少的主动脉操作与较少的斑块移位相关,从而减少栓塞
心脏手术期间发生的事件。单独治疗与单独治疗的临床结果的随机比较
多动脉移植:认知 (ROMA:Cog) 研究将确定 CABG 手术的全球影响
以及急性梗塞对认知功能的影响。第一个目标解决 CABG 手术的影响
这项技术对 2000 名国际参与者的长期认知功能进行了研究
随机分为多个动脉移植物组或单个动脉移植物组并按重要亚组,
包括女性和糖尿病患者。结果将证明认知功能的差异或
让心脏外科医生放心,认知障碍患者的比例没有差异
手术技术造成的损伤。在第二个和第三个目标中,CABG手术的短期影响
将根据认知表现领域以及 CABG 之间的关联来确定技术
手术技术、认知表现、脑梗塞和大脑健康的新型血清生物标志物
280 名参与者组成的队列。结果将为我们提供有关手术之间关系的机制细节。
技术、详细的认知表现、急性 MRI 显示脑梗死以及新型脑生物标志物
健康。利用国际 ROMA 试验基础设施(迄今为止最大的心脏手术试验之一),
我们有一个前所未有的机会来阐明 CABG 手术技术对短期和长期的影响
认知功能。预防术后认知障碍是一个重要的公共卫生问题
可以通过特定的手术技术来缓解。 ROMA:Cog 研究将有助于确定哪些人可以
受益于详细的认知评估和早期干预,并将确定血清生物标志物是否
可作为未来研究中预防血管性认知障碍的新替代终点。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Mario FL Gaudino其他文献
Mario FL Gaudino的其他文献
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{{ truncateString('Mario FL Gaudino', 18)}}的其他基金
Cardiac Magnetic Resonance Tissue Characterization of Ischemic and Non-Ischemic Myocardium to Predict Left Ventricular Functional Recovery and Outcomes after Multivessel Coronary Revascularization
缺血和非缺血心肌的心脏磁共振组织表征可预测多支冠状动脉血运重建后左心室功能恢复和结果
- 批准号:
10754011 - 财政年份:2023
- 资助金额:
$ 6.25万 - 项目类别:
Towards Personalized Prosthetic Graft Replacement for Genetically Triggered Thoracic Aortic Aneurysms
针对基因触发的胸主动脉瘤的个性化假体移植
- 批准号:
10753115 - 财政年份:2023
- 资助金额:
$ 6.25万 - 项目类别:
Randomized Comparison of the Clinical Outcome of Single Versus Multiple Arterial Grafts: Cognition (ROMA:Cog)
单动脉移植与多动脉移植临床结果的随机比较:认知 (ROMA:Cog)
- 批准号:
10777194 - 财政年份:2021
- 资助金额:
$ 6.25万 - 项目类别:
Randomized Comparison of the Clinical Outcome of Single Versus Multiple Arterial Grafts: Cognition (ROMA:Cog)
单动脉移植与多动脉移植临床结果的随机比较:认知 (ROMA:Cog)
- 批准号:
10704165 - 财政年份:2021
- 资助金额:
$ 6.25万 - 项目类别:
Randomized comparison of the clinical Outcome of single versus Multiple Arterial grafts: Cognition (ROMA:Cog)
单动脉移植物与多动脉移植物临床结果的随机比较:认知 (ROMA:Cog)
- 批准号:
10279790 - 财政年份:2021
- 资助金额:
$ 6.25万 - 项目类别:
Randomized Comparison of the Clinical Outcome of Single Versus Multiple Arterial Grafts: Cognition (ROMA:Cog)
单动脉移植与多动脉移植临床结果的随机比较:认知 (ROMA:Cog)
- 批准号:
10704165 - 财政年份:2021
- 资助金额:
$ 6.25万 - 项目类别:
Randomized Comparison of the Clinical Outcome of Single Versus Multiple Arterial Grafts: Cognition (ROMA:Cog)
单动脉移植与多动脉移植临床结果的随机比较:认知 (ROMA:Cog)
- 批准号:
10689518 - 财政年份:2021
- 资助金额:
$ 6.25万 - 项目类别:
Randomized comparison of the clinical Outcome of single versus Multiple Arterial grafts: Quality of Life (ROMA:QOL)
单动脉移植与多动脉移植临床结果的随机比较:生活质量 (ROMA:QOL)
- 批准号:
10594585 - 财政年份:2020
- 资助金额:
$ 6.25万 - 项目类别:
Randomized comparison of the clinical Outcome of single versus Multiple Arterial grafts: Quality of Life (ROMA:QOL)
单动脉移植与多动脉移植临床结果的随机比较:生活质量 (ROMA:QOL)
- 批准号:
10378019 - 财政年份:2020
- 资助金额:
$ 6.25万 - 项目类别:
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