Genomic Psychiatry Cohort

基因组精神病学队列

基本信息

批准号：
8093225
负责人：
MICHELE T PATO
金额：
$ 76.18万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-30 至 2013-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8093225
关键词：
Academic Medical Centers Bioinformatics Biological Biological Markers Bipolar Disorder Blood California Candidate Disease Gene Caucasians Caucasoid Race Characteristics Clinical Clinical Data Collaborations Collection Consent Data Deposition Diagnosis Diagnostic Disease Endowment Environmental Risk Factor Epigenetic Process Equilibrium Etiology Family history of Financial Support Foundations Funding Future General Hospitals Genetic Genetic Heterogeneity Genetic Risk Genome Genomics Genotype Geographic Locations Goals Grant Health system Human Genetics Image Indium Institutes International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10)Interview Investigation Island Latino Massachusetts Measurement Mental disorders Molecular Mutation National Institute of Mental Health Nested Case-Control Study Patients Phenotype Population Population Study Predisposition Prevention Psychiatry Psychotic Disorders Recruitment Activity Research Research Design Research Infrastructure Research Personnel Resource Sharing Resources Rest Risk Sampling Schizophrenia Single Nucleotide Polymorphism Site Specificity Specimen Stratification Structure Study Subject Symptoms Time Universities Variant Work base clinical phenotype cohort cost design experience follow-up functional genomics genetic analysis genetic resource genome wide association study genome-wide innovation instrument member patient population phenomics prospective repository research clinical testing response tool trait treatment response

项目摘要

DESCRIPTION (provided by applicant): Genomic Parsing of Bipolar Disorder and Schizophrenia: Studies of Large Cohorts in the U.S. and Across the Globe". The University of Southern California (USC Center for Genomic Psychiatry), the Massachusetts General Hospital (MGH)-Broad Institute (Stanley Center) and a nation-wide network of academic medical centers have created the Genomic Psychiatry Cohort (GPC). This application seeks to expand the resources currently available to the field, through the NIMH Repository, with an additional sample of 10,000 well-characterized patients with schizophrenia and 10,000 controls from the same geographic regions. Further, a genome-wide association study of 5,000 patients and 5,000 controls will be performed to identify genetic risks for schizophrenia. The blood/DNA from the 20,000 subjects will be deposited in the NIMH repository, along with clinical and phenotypic data, and genome wide SNP data from the GWA study. In addition, we plan to genotype the second 10,000 subjects for ancestry informative markers and replication of candidate genes. Our intent is to ascertain and recruit a large clinical cohort of patients with schizophrenia that will be prospectively followed in order to allow ongoing careful assessment of phenotype and the possibility of future nested case-control studies. We will also provide the bioinformatics and molecular infrastructure for rapid replication of specific genetic results and future potential large-scale high-throughput genomic investigations. The University of Southern California (USC) and its partners have created the Genomic Psychiatry Cohort to study very large groups of patients suffering with schizophrenia treated in their health systems. Members of the cohort are long-term patients that have agreed to participate in studies related to understanding the genetic and environmental risks for these disorders. This type of population study is critical to understanding risk, helping develop treatments, and understanding prevention of this major illness.

描述（由申请人提供）：躁郁症和精神分裂症的基因组解析：美国和全球大型同伙的研究”。南加州大学（南加州大学基因组精神病学中心），马萨诸塞州综合医院（MGH） - BROAD中心（Stanley Centute）（Stanley Institute）（Stanley Cente）（Stanley Institute）以及一个全国范围内的医疗界面，这些都创建了基因造型（GP）。通过NIMH存储库来扩展该领域的资源，并从同一地理区域进一步提供了10,000例精神分裂症患者和10,000个对照，对5,000名患者的基因组关联和5,000例对照将与精神分裂症的遗传相关。数据和GWA研究的基因组宽的数据。我们的目的是确定并招募大量精神分裂症患者的临床群体，这些患者将被前瞻性地遵循，以允许对表型进行仔细评估以及未来嵌套病例对照研究的可能性。我们还将提供生物信息学和分子基础设施，以快速复制特定的遗传结果和未来潜在的大规模高通量基因组研究。南加州大学（USC）及其合作伙伴创建了基因组精神病学队列，研究了在其卫生系统中接受精神分裂症患者的大量患者。该队列的成员是长期患者，他们同意参加与了解这些疾病的遗传和环境风险有关的研究。这种类型的人群研究对于理解风险，帮助发展治疗和理解这种主要疾病的预防至关重要。