Genomic Psychiatry Cohort

基因组精神病学队列

• 批准号: 8293379
• 负责人: MICHELE T PATO
• 金额: $ 283.24万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8293379
• 关键词: Academic Medical Centers; Bioinformatics; Biological; Biological Markers; Bipolar Disorder; Blood; California; Candidate Disease Gene; Caucasians; Caucasoid Race; Characteristics; Clinical; Clinical Data; Collaborations; Collection; Consent; DNA; Data; Deposition; Diagnosis; Diagnostic; Diagnostic and Statistical Manual; Disease; Endowment; Environmental Risk Factor; Epigenetic Process; Equilibrium; Etiology; Family history of; Financial Support; Foundations; Funding; Future; General Hospitals; Genetic; Genetic Heterogeneity; Genetic Risk; Genome; Genomics; Genotype; Geographic Locations; Goals; Grant; Health system; Human Genetics; Image; Indium; Institutes; International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10); Interview; Investigation; Island; Latino; Massachusetts; Measurement; Mental disorders; Molecular; Mutation; National Institute of Mental Health; Nested Case-Control Study; Patients; Phenotype; Population; Population Study; Predisposition; Prevention; Psychiatry; Psychotic Disorders; Recruitment Activity; Research; Research Design; Research Infrastructure; Research Personnel; Resource Sharing; Resources; Rest; Risk; Sampling; Schizophrenia; Single Nucleotide Polymorphism; Site; Specificity; Specimen; Stratification; Structure; Study Subject; Symptoms; Time; Universities; Variant; Work; base; clinical phenotype; cohort; cost effective; design; experience; follow-up; functional genomics; genetic analysis; genetic resource; genome wide association study; genome-wide; innovation; instrument; member; patient population; phenomics; prospective; repository; research clinical testing; response; tool; trait; treatment response

DESCRIPTION (provided by applicant): Genomic Parsing of Bipolar Disorder and Schizophrenia: Studies of Large Cohorts in the U.S. and Across the Globe". The University of Southern California (USC Center for Genomic Psychiatry), the Massachusetts General Hospital (MGH)-Broad Institute (Stanley Center) and a nation-wide network of academic medical centers have created the Genomic Psychiatry Cohort (GPC). This application seeks to expand the resources currently available to the field, through the NIMH Repository, with an additional sample of 10,000 well-characterized patients with schizophrenia and 10,000 controls from the same geographic regions. Further, a genome-wide association study of 5,000 patients and 5,000 controls will be performed to identify genetic risks for schizophrenia. The blood/DNA from the 20,000 subjects will be deposited in the NIMH repository, along with clinical and phenotypic data, and genome wide SNP data from the GWA study. In addition, we plan to genotype the second 10,000 subjects for ancestry informative markers and replication of candidate genes. Our intent is to ascertain and recruit a large clinical cohort of patients with schizophrenia that will be prospectively followed in order to allow ongoing careful assessment of phenotype and the possibility of future nested case-control studies. We will also provide the bioinformatics and molecular infrastructure for rapid replication of specific genetic results and future potential large-scale high-throughput genomic investigations. The University of Southern California (USC) and its partners have created the Genomic Psychiatry Cohort to study very large groups of patients suffering with schizophrenia treated in their health systems. Members of the cohort are long-term patients that have agreed to participate in studies related to understanding the genetic and environmental risks for these disorders. This type of population study is critical to understanding risk, helping develop treatments, and understanding prevention of this major illness.

描述（由申请人提供）：双相情感障碍和精神分裂症的基因组解析：美国和全球大型队列的研究”。南加州大学（南加州大学基因组精神病学中心）、马萨诸塞州综合医院 (MGH)-Broad研究所（斯坦利中心）和全国学术医疗中心网络创建了基因组精神病学队列（GPC）。通过 NIMH 存储库，扩大该领域目前可用的资源，额外样本包括来自同一地理区域的 10,000 名特征明确的精神分裂症患者和 10,000 名对照者。此外，还开展了一项针对 5,000 名患者和 5,000 名对照者的全基因组关联研究。将进行鉴定精神分裂症的遗传风险 20,000 名受试者的血液/DNA 将被保存。 NIMH 存储库中的数据，以及来自 GWA 研究的临床和表型数据以及全基因组 SNP 数据。此外，我们计划对第二批 10,000 名受试者进行基因分型，以获取祖先信息标记和候选基因的复制。我们的目的是确定并招募大量精神分裂症患者的临床队列，对这些患者进行前瞻性随访，以便对表型进行持续仔细的评估，并为未来进行巢式病例对照研究提供可能性。我们还将提供生物信息学和分子基础设施，用于快速复制特定遗传结果和未来潜在的大规模高通量基因组研究。南加州大学 (USC) 及其合作伙伴创建了基因组精神病学队列，以研究在其卫生系统中接受治疗的大量精神分裂症患者。该队列的成员是长期患者，他们同意参与有关了解这些疾病的遗传和环境风险的研究。此类人群研究对于了解风险、帮助开发治疗方法以及了解这种重大疾病的预防至关重要。