Cannabis Vapor Exposure Impacts Reproduction

大麻蒸气暴露影响繁殖

基本信息

批准号：
10703501
负责人：
KANAKO HAYASHI
金额：
$ 18.48万
依托单位：
WASHINGTON STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-15 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10703501
关键词：
Abnormal placentation Adult Adverse effects Affect Age American Apoptosis Cannabidiol Cannabis Chronic Consumption Control Groups DNA DNA Damage DNA Methylation DNA Modification Methylases Data Defect Discipline of Nursing Drug usage Epigenetic Process Estrous Cycle Ethics Exhibits Exposure to Female Fertility First Pregnancy Trimester Generations Germ Cells Health Human Inherited Knowledge Menstruation Mus Neonatal Outcome Ovary Partner in relationship Paternal Exposure Pharmaceutical Preparations Phenotype Plants Plasma Population Pregnancy Pregnant Women Premature Birth Psychoses Psychotropic Drugs Reporting Reproduction Risk Socioeconomic Factors Sperm Count Procedure Sperm Motility Standardization Surveys Testing Testis Tetrahydrocannabinol Toxicology United States Vagina bisphenol A design histone methyltransferase histone modification in utero insight male marijuana legalization marijuana use marijuana user methylome offspring postnatal pregnant reproductive reproductive function sperm cell steroid hormone stillbirth transcriptome transmission process vapor

项目摘要

Project Summary Cannabis is considered the most widely used psychoactive drug in the United States and all over the world. In 2020, the National Survey on Drug Use and Health (NSDUH) has reported that over 48 million Americans (~16% of the population) ages 12 and older used cannabis in the past year. This number has increased due to the expanding legalization of cannabis consumption in the US. Higher potency strains of cannabis plants have emerged over the past two decades. Unsurprisingly, adverse health outcomes associated with cannabis consumption have also been increasing. The proposed study will provide the first impact, which is the transgenerational effects of in utero and nursing cannabis vapor exposure on phenotypic defects of male and female reproductive functions. Because cannabis is a psychoactive drug, chronic or frequent use of cannabis is associated with a variety of adverse health outcomes. However, little is known about its effects on reproduction, especially the long-term consequences of cannabis on offspring and subsequent generations. To date, no systematic studies examining reproductive phenotypic defects and their associated mechanisms caused by cannabis have been performed. In addition, it is entirely unknown whether the adverse effects of cannabis on reproduction are sustained via germline transmission to subsequent generations. Therefore, this application proposes as a first step to examine the transgenerational effects of cannabis vapor exposure on male and female reproductive functions. We will characterize how cannabis vapor exposure during pregnancy and nursing affects male and female reproductive parameters in neonatal and adult testes and ovaries to understand paternally or maternally transmitted alterations in male or female germ cells. Because at least 7% of pregnant women use cannabis throughout pregnancy (~12% during the first trimester and 5.3% daily users), an appreciation of the impact of cannabis use on reproductive functions in subsequent offspring is crucial.

项目概要大麻被认为是美国和世界各地使用最广泛的精神活性药物。在 2020 年，全国药物使用与健康调查 (NSDUH) 报告称，超过 4800 万美国人（约 16% 的人口）12 岁及以上的人在过去一年中使用过大麻。这个数字增加的原因是美国大麻消费合法化的扩大。大麻植物的效力较高的菌株具有是在过去二十年中出现的。毫不奇怪，与大麻相关的不良健康结果消费也不断增加。拟议的研究将提供第一个影响，即子宫内和哺乳期大麻蒸气暴露对男性和女性表型缺陷的跨代影响女性生殖功能。由于大麻是一种精神活性药物，长期或频繁使用大麻与多种不良健康结果相关。然而，人们对它的影响却知之甚少生殖，特别是大麻对后代和后代的长期影响。到迄今为止，还没有系统研究检查生殖表型缺陷及其相关机制由大麻引起的已进行。此外，完全未知是否会产生不良影响。大麻的繁殖是通过种系传递给后代来维持的。因此，这申请建议第一步检查大麻蒸气暴露对人的跨代影响男性和女性的生殖功能。我们将描述怀孕期间如何接触大麻蒸气护理会影响新生儿和成人睾丸和卵巢的男性和女性生殖参数了解男性或女性生殖细胞的父系或母系遗传改变。因为至少有7% 的孕妇在整个怀孕期间使用大麻（约 12% 在妊娠前三个月使用大麻，5.3% 每天使用大麻），了解大麻的使用对后代生殖功能的影响至关重要。