TORS - Interdisciplinary Research Training Program, Project 8 of 10 TL1

TORS - 跨学科研究培训计划，项目 8（共 10 个）TL1

• 批准号: 8111375
• 负责人: JOYCE J REPA
• 金额: $ 5.25万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8111375
• 关键词: Address; Behavioral; Biochemistry; Biomedical Research; Cardiovascular Diseases; Clinical; Comorbidity; Core Facility; Development; Diabetes Mellitus; Doctor of Medicine; Doctor of Philosophy; Educational Curriculum; Energy Metabolism; Environment; Event; Faculty; Fellowship; Gastroenterology; Genetic; Health; Hepatology; Human; Human Genetics; Hypertension; Image; Individual; Interdisciplinary Study; Knowledge; Laboratories; Language; Learning; Liver diseases; Mentors; Metabolic; Metabolic syndrome; Metabolism; Molecular; Molecular Biology; Molecular Genetics; Neuroanatomy; Neurobiology; Obesity; Physiology; Population; Psychiatry; Radiology Specialty; Regulation; Research; Research Personnel; Research Project Grants; Research Training; Societies; Stroke; Technology; Training; Training Programs; Work; bariatric surgery; career development; clinical epidemiology; design; experience; in vivo; member; mouse model; non-alcoholic fatty liver; nutrition; post-doctoral training; programs; responsible research conduct

Obesity and its associated co-morbidities are major health problems in our society, contributing to diabetes mellitus, cardiovascular disease and stroke, hypertension, and non-alcoholic fatty liver disease. The objective of this postdoctoral training program is to provide a productive learning experience in biomedical research related to obesity. This application describes a comprehensive training program that takes advantage of a cadre of distinguished faculty mentors, a strong research environment endowed with technology core facilities, an extensive array of genetically defined mouse models and established human clinical populations, anda curriculum that allows educational opportunities to augment scientific knowledge, career development, and training in the responsible conduct of research. This program is unique in that a trainee will receive mentoring from twofaculty members, each of a distinct scientific team , to promote the development and execution of an interdisciplinary research project to examinethe behavioral, metabolic, and molecular events that cause obesity and the metabolic syndrome. This team-approach is supported by the collaborative environment of our 26 faculty members, drawn from 14 different Departments and Centers that have been organized into four teams to focus on The Central Regulation of Energy Metabolism (Team 1: Neuroanatomy, Neurobiology, Psychiatry), The Molecular Biology of Energy Metabolism (Team 2: Biochemistry, Molecular Genetics, Molecular Biology, and Physiology), In vivo Intermediary Metabolism (Team 3: Advanced Imaging, Human Nutrition, Hepatology/Gastroenterology), and Human Genetics and Energy Metabolism (Team 4: Bariatric Surgery, Clinical Epidemiology, and Genetics). Individuals accepted into this program will have a Ph.D., M.D./Ph.D., or M.D. degree and will have acquired some experience in one of manydisciplines integral to this work prior to beginning their three-year fellowship. However, their training with two mentors,and work in two or more collaborative laboratory settings will allow them to become fluent in multiple, often disparate scientific languages (e.g. molecular biology, radiology, neuroanatomay,.nutrition, psychiatry, human genetics) thus permitting them to critically address unique scientific problems in an interdisciplinary manner. This program is designed, therefore, to train individuals who will become effectiveteachers and investigators capable of cutting-edge research in obesity.

肥胖及其相关的合并症是我们社会的主要健康问题，导致糖尿病 梅利氏菌，心血管疾病和中风，高血压和非酒精性脂肪肝疾病。这 该博士后培训计划的目的是提供生物医学的富有成效的学习经验 与肥胖有关的研究。该应用程序描述了一个全面的培训计划 杰出教师导师的干部的优势，一个强大的研究环境 技术核心设施，一系列遗传定义的鼠标模型，并建立了人类 临床人群，ANDA课程，允许教育机会增加科学知识， 职业发展和负责任的研究培训。这个程序是独一无二的 实习生将获得来自两个独特科学团队的两名教师的指导，以促进 开发和执行一个跨学科研究项目，以检查行为，代谢， 以及导致肥胖症和代谢综合征的分子事件。这个团队的诉求得到 来自14个不同部门和中心的26位教职员工的协作环境 已经组织成四个团队，专注于能源代谢的中心法规（团队 1：神经解剖学，神经生物学，精神病学），能量代谢的分子生物学（团队2： 生物化学，分子遗传学，分子生物学和生理学），体内中介代谢 （团队3：高级成像，人类营养，肝病学/胃肠病学）以及人类遗传学 能源代谢（团队4：减肥手术，临床流行病学和遗传学）。个人接受 进入该计划将拥有博士学位，M.D./PH.D。或M.D.学位，将获得一些经验 在开始三年奖学金之前，这项工作不可或缺的许多学科之一。但是，他们 与两名导师进行培训，并在两个或两个或多个协作实验室环境中工作将使他们能够 流利的多种，通常不同的科学语言（例如，分子生物学，放射学， 神经植物，营养，精神病学，人类遗传学），因此允许他们批判性地解决独特的问题 以跨学科的方式进行科学问题。因此，该程序的设计是为了培训个人 谁将成为能够在肥胖方面进行尖端研究的有效教师和调查人员。