The Alzheimer's Disease Translational Data Science Training Program

阿尔茨海默病转化数据科学培训计划

基本信息

批准号：
10686916
负责人：
William S Bush
金额：
$ 27.44万
依托单位：
CASE WESTERN RESERVE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2026-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10686916
关键词：
Alzheimer&apos s Disease Data Science Training Programs

项目摘要

PROJECT SUMMARY/ABSTRACT (DESCRIPTION) The Case Western Reserve University (CWRU) Alzheimer’s Disease Translational Data Science (ADTDS) Training Program is designed to power therapeutic discovery by producing a new generation of scientists cross- trained in clinical research of Alzheimer’s Disease (AD) and analysis of large scale ‘omics data. Focused on predoctoral PhD and MD PhD students, this training program fills a critical gap between these disciplines in academic graduate programs. The ADTDS builds upon the Cleveland Alzheimer’s Disease Research Center (CADRC), and multiple ongoing national collaborations responsible for generating large-scale multi-omic data on diverse populations with AD. As part of this training program, trainees will: 1) Form multi-disciplinary mentorship teams to expand understanding of AD etiology and disease course through data analysis, 2) Interact with a variety of faculty who are world-recognized leaders in AD genetics, pathology, and neuroscience, 3) Access large-scale data from national initiatives supported by NIA, including the ADSP, ADGC, ADNI, and AMP- AD, to answer translational and basic research questions, and 4) Receive specialized training in responsible conduct and research reproducibility with special considerations for data science. Our cross-disciplinary training program provides strong mentoring and uses state-of-the-art data science experiences within the rich environment of the CWRU School of Medicine and its affiliated hospital systems to develop independent investigators who will lead the next generation of translational research in Alzheimer’s Disease.

项目摘要/摘要（描述）凯斯西储大学 (CWRU) 阿尔茨海默病转化数据科学 (ADTDS) 培训计划旨在通过培养跨学科的新一代科学家来推动治疗发现接受过阿尔茨海默病（AD）临床研究和大规模组学数据分析方面的培训。博士前博士生和医学博士生，该培训计划填补了这些学科之间的关键空白 ADTDS 建立在克利夫兰阿尔茨海默病研究中心的基础上。（CADRC），以及多个正在进行的国家合作，负责生成大规模多组学数据作为本培训计划的一部分，学员将： 1) 形成多学科的能力。指导团队通过数据分析扩大对 AD 病因和疾病过程的了解，2) 互动拥有 AD 遗传学、病理学和神经科学领域世界公认的领导者的各种教师，3) 访问 NIA 支持的国家计划的大规模数据，包括 ADSP、ADGC、ADNI 和 AMP- AD，回答转化和基础研究问题，以及 4) 接受负责的专门培训我们的跨学科培训特别考虑了行为和研究的可重复性。该计划提供强有力的指导，并利用丰富的最先进的数据科学经验 CWRU 医学院及其附属医院系统的环境，以开发独立的研究人员将领导下一代阿尔茨海默病转化研究。

项目成果

期刊论文数量（1）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Genetic analysis of cognitive preservation in the midwestern Amish reveals a novel locus on chromosome 2.

对中西部阿米什人认知保存的遗传分析揭示了 2 号染色体上的一个新基因座。

DOI：
发表时间：
2023-12-14
期刊：
影响因子：
0
作者：
Main, Leighanne R;Song, Yeunjoo E;Lynn, Audrey;Laux, Renee A;Miskimen, Kristy L;Osterman, Michael D;Cuccaro, Michael L;Ogrocki, Paula K;Lerner, Alan J;Vance, Jeffery M;Fuzzell, M Denise;Fuzzell, Sarada L;Hochstetler, Sherri D;Dorfsman, Daniel
通讯作者：
Dorfsman, Daniel

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William S Bush其他文献

DNA from multiple viral species is associated with Alzheimer's disease risk

来自多种病毒物种的 DNA 与阿尔茨海默病风险相关

DOI：
10.1002/alz.13414
发表时间：
2023-08-14
期刊：
Alzheimer's & Dementia
影响因子：
0
作者：
Marlene Tejeda;J. Farrell;Congcong Zhu;L. Wetzler;Kathryn L. Lunetta;William S Bush;Eden Martin;Li;Gerard D Schellenberg;M. Pericak;J. Haines;Lindsay A Farrer;Richard Sherva
通讯作者：
Richard Sherva

Methylome-wide analysis reveals epigenetic marks associated with resistance to tuberculosis in HIV-infected individuals from East Africa.

全甲基化分析揭示了东非艾滋病毒感染者与结核病抵抗力相关的表观遗传标记。

DOI：
发表时间：
2021
期刊：
Journal of Infectious Diseases
影响因子：
6.4
作者：
Catherine M. Stein;Penelope Benchek;J. Bartlett;R. Igo;Rafal S. Sobota;K. Chervenak;Harriet Mayanja;C. F. von Reyn;Timothy Lahey;William S Bush;W. H. Boom;William K. Scott;Carmen J. Marsit;Giorgio Sirugo;Scott M. Williams
通讯作者：
Scott M. Williams

T-cell receptor diversity in minimal change disease in the NEPTUNE study

NEPTUNE 研究中微小病变性疾病中 T 细胞受体的多样性

DOI：
10.1007/s00467-022-05696-x
发表时间：
2023-04
期刊：
Pediatric Nephrology
影响因子：
3
作者：
Shiying Liu;William S Bush;K. Miskimen;Agustin Gonzalez;Jessica N. Cooke Bailey;I. Konidari;Jacob L. McCauley;J. Sedor;John F. O'Toole;Dana C Crawford
通讯作者：
Dana C Crawford

Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

通过多祖先全基因组发现 187 种新风险变异来表征前列腺癌风险

DOI：
10.1038/s41588-023-01534-4
发表时间：
2023-11-09
期刊：
Nature Genetics
影响因子：
30.8
作者：
Anqi Wang;Jiayi Shen;Alex Rodriguez;E. Saunders;Fei Chen;Rohini Janivara;B. Darst;Xin Sheng;Yili Xu;Alisha Chou;S. Benlloch;Tokhir Dadaev;M. Brook;A. Plym;A. Sahimi;Thomas J Hoffman;Atushi Takahashi;K. Matsuda;Y. Momozawa;Masashi Fujita;T. Laisk;Jessica Figueredo;Kenneth R. Muir;Shuji Ito;Xiaoxi Liu;Yuji Uchio;M. Kubo;Y. Kamatani;A. Lophatananon;Peggy Wan;Caroline Andrews;Adriana Lori;P. Choudhury;J. Schleutker;T. Tammela;C. Sipeky;Anssi Auvinen;Graham G. Giles;M. Southey;R. MacInnis;C. Cybulski;D. Wokołorczyk;J. Lubiński;C. Rentsch;Kelly Cho;Benjamin H. McMahon;D. Neal;J. Donovan;F. Hamdy;Richard M. Martin;B. Nordestgaard;S. F. Nielsen;Maren Weischer;S. Bojesen;Andreas Røder;H. V. Stroomberg;J. Batra;Suzanne K. Chambers;L. Horvath;Judith A. Clements;Wayne Tilly;G. Risbridger;H. Gronberg;M. Aly;R. Szulkin;Martin Eklund;T. Nordstrom;Nora Pashayan;A. Dunning;M. Ghoussaini;R. Travis;Tim J Key;E. Riboli;Jong Y. Park;T. A. Sellers;Hui Lin;D. Albanes;S. Weinstein;Michael B. Cook;L. Mucci;E. Giovannucci;S. Lindstrom;P. Kraft;David J Hunter;K. Penney;Constance Turman;C. Tangen;P. Goodman;Ian M. Thompson;Robert J. Hamilton;Neil Fleshner;A. Finelli;M. Parent;Janet L. Stanford;Elaine A. Ostrander;Stella Koutros;L. B. Beane Freeman;M. Stampfer;A. Wolk;N. Håkansson;Gerald L. Andriole;R. N. Hoover;M. Machiela;K. D. Sørensen;Michael Borre;William J Blot;W. Zheng;E. Yeboah;James E Mensah;Yong;Hong;Ninghan Feng;Xueying Mao;Yudong Wu;Shan;Zan Sun;S N Thibodeau;S. McDonnell;D. Schaid;C. West;Gill Barnett;C. Maier;T. Schnoeller;Manuel Luedeke;A. Kibel;Bettina F Drake;O. Cussenot;G. Cancel;F. Menegaux;Thérèse Truong;Y. Koudou;Esther M John;E. Grindedal;L. Maehle;K. Khaw;S. Ingles;M. Stern;Ana Vega;A. Gómez;L. Fachal;B. Rosenstein;Sarah L. Kerns;H. Ostrer;Manuel R Teixeira;P. Paulo;Andreia Brandão;S. Watya;Alex Lubwama;J. Bensen;Eboneé N. Butler;James L Mohler;Jack A. Taylor;M. Kogevinas;T. Dierssen;G. Castaño‐Vinyals;L. Cannon;C. Teerlink;Chad D Huff;P. Pilié;Yao Yu;R. Bohlender;Jian Gu;Sara S. Strom;L. Multigner;P. Blanchet;L. Brureau;R. Kaneva;C. Slavov;V. Mitev;Robin J. Leach;H. Brenner;Xuechen Chen;Bernd Holleczek;B. Schöttker;Eric A Klein;A. Hsing;Rick A. Kittles;Adam B. Murphy;Christopher J. Logothetis;Jeri Kim;S. Neuhausen;L. Steele;Y. Ding;W. Isaacs;B. Nemesure;A. Hennis;J. Carpten;H. Pandha;Agnieszka Michael;K. De Ruyck;G. De Meerleer;P. Ost;Jianfeng Xu;A. Razack;Jasmine Lim;Soo;Lisa F. Newcomb;Daniel W. Lin;J. Fowke;C. Neslund;B. Rybicki;Marija Gamulin;D. Lessel;T. Kuliš;N. Usmani;A. Abraham;Sandeep Singhal;M. Parliament;Frank Claessens;Steven Joniau;T. Van den Broeck;M. Gago;J. Castelao;María Elena Martínez;Samantha E. T. Larkin;Paul A. Townsend;Claire Aukim;William S Bush;M. Aldrich;Dana C Crawford;S. Srivastava;Jennifer Cullen;G. Petrovics;G. Casey;Ying Wang;Y. Tettey;J. Lachance;Wei Tang;R. Biritwum;A. Adjei;Evelyn Tay;A. Truelove;S. Niwa;K. Yamoah;K. Govindasami;A. Chokkalingam;Jacob M. Keaton;J. Hellwege;Peter E. Clark;M. Jalloh;S. Gueye;L. Niang;O. Ogunbiyi;Olayiwola Shittu;O. Amodu;A. Adebiyi;O. Aisuodionoe;Hafees O Ajibola;M. Jamda;O. Oluwole;Maxwell Nwegbu;B. Adusei;S. Mante;Afua Darkwa;H. Diop;Susan M Gundell;M. Roobol;G. Jenster;Ron H N van Schaik;Jennifer J Hu;M. Sanderson;L. Kachuri;Rohit Varma;R. Mckean;M. Torres;Michael H. Preuss;R. Loos;M. Zawistowski;Sebastian Zöllner;Zeyun Lu;S. K. Van Den Eeden;D. Easton;S. Ambs;T. Edwards;R. Mägi;Timothy R Rebbeck;L. Fritsche;S. Chanock;S. I. Berndt;F. Wiklund;H. Nakagawa;John S. Witte;J. Gaziano;Amy C Justice;N. Mancuso;C. Terao;R. Eeles;Z. Kote;R. Madduri;David V Conti;C. Haiman
通讯作者：
C. Haiman

the genetic etiology

遗传病因学

DOI：
发表时间：
2024-09-14
期刊：
影响因子：
0
作者：
C. Bellenguez;L. Kleineidam;Amin Najaf Sonia;A. Naj;Grenier;Andrade Victor Holmans Peter A Benjamin;A. Bol;van der Lee Vincent;Costa Sven J.;Kuulasmaa Marcos R.;Carla Abdelnour;Alcolea Emilio;Alegret Daniel;Alvarez Ignacio Álvarez Victoria Armstrong Montserrat;Arosio Beatrice Athanasiu Lavinia Bailly Henri Banaj Neri Alfonso Arias;Below Ana Belén;Blesa Rafael Boada Mercè Boerwinkle Eric Borroni Barbara Aless;ra;Henry;Keeley J. Brookes;Luis Ignacio;Buiza;Katharina Burholt Vanessa Dolores Bûrger;William S Bush;Cantwell Miguel;Laura Cervera;C. Charbonnier;Hung;J. A. Claassen;A. Corma;Carolina;Daniele;Dardiotis Efthimios Dartigues Jean;D. Deyn;Peter Paul;Paiva Lopes;de Witte Lot D Katia;del Ser;Denning Teodoro;Nicola DeStefano;Dichgans Anita;Diez;Djurovic Srdjan Duron Emmanuelle Düzel Emrah Dufouil Carole Paolo Dionigi;Espinosa Valentina;Ewers Michael Faber Ana;Sune Fallgaard;D. Fardo;Fenoglio;Chiara;Harald Hanon Kara L Hampel;Hardy John Hartmann Annette M Olivier;Holmes Clive Holstege Henne Vilas Raquel Huerto Per;Seshadri Sudha Andreassen Ole A Giacomina;M. Ingelsson;Cornelia M. Van Duijn;R. Sims;W. M. van der Flier;Agustin Ruiz;Jean;A. Palotie;M. Daly;H. Jacob;A. Matakidou;H. Runz;S. John;R. Plenge;M. Mccarthy;J. Hunkapiller;Meg Ehm;D. Waterworth;Caroline Fox;A. Malarstig;K. Klinger;Kathy Call;tim Behrens;P. Loerch;T. Mäkelä;J. Kaprio;P. Virolainen;Kari Pulkki;Kilpi;M. Perola;J. Partanen;A. Pitkäranta;Kaarteenaho;S. Vainio;M. Turpeinen;R. Serpi;Tarja Laitinen;J. Mäkelä;V. Kosma;Kujala;Outi Tuovila;Minna Hendolin;Pakkanen;J. Waring;B. Riley;Jimmy Z Liu;Shameek Biswas;D. Diogo;C. Marshall;Xinli Hu;M. Gossel;Rob Graham;Beryl B. Cummings;S. Ripatti;J. Schleutker;Mikko Arvas;reetta Hinttala Olli carpén 347;J. Kettunen;A. Mannermaa;J. Laukkanen;Valtteri Julkunen;A. Remes;Kälviäinen;J. Peltola;P. Tienari;Juha O. Rinne;A. Ziemann;S. Esmaeeli;N. Smaoui;A. Lehtonen;Susan Eaton;S. Lahdenperä;J. Adelsberg;J. Michon;Geoff Kerchner;Natalie Bowers;John D. Eicher;Vinay Mehta;P. Gormley;K. Lindén;Christopher Whelan;Fanli Xu;D. Pulford;Martti A Färkkilä;S. Pikkarainen;A. Jussila;T. Blomster;M. Kiviniemi;M. Voutilainen;Bob Georgantas;Graham A. R. Heap;F. Rahimov;K. Usiskin;Tim Lu;D. Oh;Kirsi Kalpala;Melissa Miller;L. Mccarthy;Kari K Eklund;A. Palomäki;P. Isomäki;L. Pirilä;O. Kaipiainen;Johanna Huhtakangas;A. Lertratanakul;M. Hochfeld;N. Bing;J. Gordillo;N. Mars;Margit K. Pelkonen;P. Kauppi;H. Kankaanranta;Harju;David W. Close;Steven Greenberg;Hubert Chen;Jo Betts;Soumitra Ghosh;V. Salomaa;Niiranen;M. Juonala;K. Metsärinne;M. Kähönen;J. Junttila;Markku Laakso;J. Pihlajamäki;J. Sinisalo;M. Taskinen;Bennett Challis;Andrew Peterson;Audrey M. Chu;J. Parkkinen;Anthony Muslin;H. Joensuu;Meretoja;L. Aaltonen;Johanna Mattson;A. Auranen;P. Karihtala;S. Kauppila;P. Auvinen;K. Elenius;Popovic;J. Schutzman;Andrey Loboda;A. Chhibber;Heli J. Lehtonen;S. McDonough;Marika Crohns;Diptee A. Kulkarni;K. Kaarniranta;terhi Ollila Joni A. turunen 356;S. Seitsonen;Hannu Uusitalo;V. Aaltonen;H. Uusitalo;M. Luodonpää;N. Hautala;Stephanie Loomis;Erich Strauss;Hao Chen;Anna I. Podgornaia;Joshua Hoffman;K. Tasanen;L. Huilaja;K. Hannula;Salmi;S. Peltonen;L. Koulu;Harvima;Ying Wu;David Choy;P. Pussinen;A. Salminen;Salo;Dave Rice;Pekka Nieminen;U. Palotie;M. Siponen;L. Suominen;P. Mäntylä;Gursoy;V. Anttonen;K. Sipilä;J. Davis;D. Quarless;S. Petrovski;Eleonor Wigmore;Chia;P. Bronson;Ellen A. Tsai;Yunfeng Huang;Joseph C Maranville;Samir Wadhawan;E. Kvikstad;Minal caliskan;tushar Bhangale Diana chang 336;S. Pendergrass;E. Holzinger;Xing Chen;Å. Hedman;Karen S. King;C;E. Xu;F. Augé;C. Chatelain;D. Rajpal;Dongyu Liu;Kathy Call;Tai;Matt Brauer;M. Kurki;J. Karjalainen;A. Havulinna;A. Jalanko;P. Palta;Pietro della;Briotta Parolo;Wei Zhou;S. Lemmelä;M. Rivas;J. Harju;Arto A Lehisto;A. Ganna;V. Llorens;H. Laivuori;S. Rüeger;Mari E. K. Niemi;tukiainen 331;Mary Pat reeve 331;H. Heyne;Kimmo Palin;Javier Garcia;H. Siirtola;Kiiskinen;Jiwoo Lee;K. Tsuo;A. Elliott;K. Kristiansson;K. Hyvärinen;J. Ritari;Miika Koskinen;K. Pylkäs;Marita Kalaoja;Minna M. Karjalainen;Mantere;Kangasniemi;S. Heikkinen;Laakkonen;Sipeky;S. Heron;A. Karlsson;Dhanaprakash Jambulingam;V. Rathinakannan;Risto Kajanne;M. Aavikko;Manuel González Jiménez;Pietro della Briotta Parola;Arto Lehistö;M. Kanai;M. Kaunisto;Elina Kilpeläinen;P. Sipilä;Georg Brein;Ghazal Awaisa;Anastasia Shcherban;K. Donner;A. Loukola;P. Laiho;Sistonen;Kaiharju;Markku Laukkanen;Elina Järvensivu;S. Lähteenmäki;Lotta Männikkö;Wong;Hannele Mattsson;T. Hiekkalinna;Paajanen;K. Pärn;Javier Gracia;Martin Woon;B. Wright;chuang;S. Younkin;chang;Lei Yu;Yuanchao Zhang;Yi Zhao;Xiongwei Zhu
通讯作者：
Xiongwei Zhu