Project 1: Genetic Discovery Within Diverse Ancestry Cohorts

项目 1：不同血统群体中的基因发现

基本信息

批准号：
10333060
负责人：
William S Bush
金额：
$ 63.43万
依托单位：
UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-07-01 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10333060
关键词：
Accounting Address African African American African American population African Caribbean Aging Alleles Alzheimer&apos s Disease Alzheimer&apos s disease model Alzheimer&apos s disease risk American Biological Biological Markers Caribbean Hispanic Cells Chromosomes Code Communities Complex Custom Data Data Collection Economics Enrollment Epigenetic Process Ethnic group Genes Genetic Genetic Variation Genomics Genotype Goals Health Policy Heritability Hispanic Latinx Latinx population Localized Disease Logistics Methods Modeling Molecular Neurodegenerative Disorders Not Hispanic or Latino Participant Pathway Analysis Pathway interactions Phenotype Population Population Heterogeneity Public Health Race Regulatory Element Resources Risk Risk Factors Sample Size Sampling Site Standardization Statistical Data Interpretation Testing Tissues Trans-Omics for Precision Medicine Variant adjudicate adjudication base clinical practice cohort data management genetic architecture genetic risk factor genetic testing genetic variant genome wide association study genome-wide genomic biomarker health disparity improved multi-ethnic novel outreach predictive modeling recruit social transcriptome

项目摘要

PROJECT SUMMARY The genomics of Alzheimer Disease is complex and evidence to date suggests that different ancestry groups have distinct genetic factors that influence risk. In this project, we will perform multiple statistical analyses of generated genetic data in African American, African, and Hispanic/Latinx populations to identify genetic factors that are distinct within those groups. We will develop and apply new methods for identifying regulatory elements and leveraging admixed chromosomes that are features of these populations. Finally, we will summarize results through polygenic and pathway analyses to identify specific molecular mechanisms that harbor genetic variants influence Alzheimer risk in each of these populations.

项目概要阿尔茨海默病的基因组学很复杂，迄今为止的证据表明不同的血统群体具有影响风险的独特遗传因素。在这个项目中，我们将进行多项统计分析生成非裔美国人、非洲人和西班牙裔/拉丁裔人群的遗传数据，以识别遗传因素在这些群体中是不同的。我们将开发并应用新方法来识别监管要素并利用这些种群特征的混合染色体。最后我们来总结一下结果通过多基因和途径分析来识别包含遗传变异的特定分子机制影响每个人群的阿尔茨海默病风险。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

数据更新时间：{{ journalArticles.updateTime }}

DOI：
{{ item.doi }}
发表时间：
{{ item.publish_year }}
期刊：
{{ item.journal_name }}
影响因子：
{{ item.factor }}
作者：
{{ item.authors }}
通讯作者：
{{ item.author }}

数据更新时间：{{ journalArticles.updateTime }}

作者：
{{ item.author }}

数据更新时间：{{ monograph.updateTime }}

作者：
{{ item.author }}

数据更新时间：{{ sciAawards.updateTime }}

作者：
{{ item.author }}

数据更新时间：{{ conferencePapers.updateTime }}

作者：
{{ item.author }}

数据更新时间：{{ patent.updateTime }}

William S Bush其他文献

DNA from multiple viral species is associated with Alzheimer's disease risk

来自多种病毒物种的 DNA 与阿尔茨海默病风险相关

DOI：
10.1002/alz.13414
发表时间：
2023-08-14
期刊：
Alzheimer's & Dementia
影响因子：
0
作者：
Marlene Tejeda;J. Farrell;Congcong Zhu;L. Wetzler;Kathryn L. Lunetta;William S Bush;Eden Martin;Li;Gerard D Schellenberg;M. Pericak;J. Haines;Lindsay A Farrer;Richard Sherva
通讯作者：
Richard Sherva

Methylome-wide analysis reveals epigenetic marks associated with resistance to tuberculosis in HIV-infected individuals from East Africa.

全甲基化分析揭示了东非艾滋病毒感染者与结核病抵抗力相关的表观遗传标记。

DOI：
发表时间：
2021
期刊：
Journal of Infectious Diseases
影响因子：
6.4
作者：
Catherine M. Stein;Penelope Benchek;J. Bartlett;R. Igo;Rafal S. Sobota;K. Chervenak;Harriet Mayanja;C. F. von Reyn;Timothy Lahey;William S Bush;W. H. Boom;William K. Scott;Carmen J. Marsit;Giorgio Sirugo;Scott M. Williams
通讯作者：
Scott M. Williams

T-cell receptor diversity in minimal change disease in the NEPTUNE study

NEPTUNE 研究中微小病变性疾病中 T 细胞受体的多样性

DOI：
10.1007/s00467-022-05696-x
发表时间：
2023-04
期刊：
Pediatric Nephrology
影响因子：
3
作者：
Shiying Liu;William S Bush;K. Miskimen;Agustin Gonzalez;Jessica N. Cooke Bailey;I. Konidari;Jacob L. McCauley;J. Sedor;John F. O'Toole;Dana C Crawford
通讯作者：
Dana C Crawford

Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

通过多祖先全基因组发现 187 种新风险变异来表征前列腺癌风险

DOI：
10.1038/s41588-023-01534-4
发表时间：
2023-11-09
期刊：
Nature Genetics
影响因子：
30.8
作者：
Anqi Wang;Jiayi Shen;Alex Rodriguez;E. Saunders;Fei Chen;Rohini Janivara;B. Darst;Xin Sheng;Yili Xu;Alisha Chou;S. Benlloch;Tokhir Dadaev;M. Brook;A. Plym;A. Sahimi;Thomas J Hoffman;Atushi Takahashi;K. Matsuda;Y. Momozawa;Masashi Fujita;T. Laisk;Jessica Figueredo;Kenneth R. Muir;Shuji Ito;Xiaoxi Liu;Yuji Uchio;M. Kubo;Y. Kamatani;A. Lophatananon;Peggy Wan;Caroline Andrews;Adriana Lori;P. Choudhury;J. Schleutker;T. Tammela;C. Sipeky;Anssi Auvinen;Graham G. Giles;M. Southey;R. MacInnis;C. Cybulski;D. Wokołorczyk;J. Lubiński;C. Rentsch;Kelly Cho;Benjamin H. McMahon;D. Neal;J. Donovan;F. Hamdy;Richard M. Martin;B. Nordestgaard;S. F. Nielsen;Maren Weischer;S. Bojesen;Andreas Røder;H. V. Stroomberg;J. Batra;Suzanne K. Chambers;L. Horvath;Judith A. Clements;Wayne Tilly;G. Risbridger;H. Gronberg;M. Aly;R. Szulkin;Martin Eklund;T. Nordstrom;Nora Pashayan;A. Dunning;M. Ghoussaini;R. Travis;Tim J Key;E. Riboli;Jong Y. Park;T. A. Sellers;Hui Lin;D. Albanes;S. Weinstein;Michael B. Cook;L. Mucci;E. Giovannucci;S. Lindstrom;P. Kraft;David J Hunter;K. Penney;Constance Turman;C. Tangen;P. Goodman;Ian M. Thompson;Robert J. Hamilton;Neil Fleshner;A. Finelli;M. Parent;Janet L. Stanford;Elaine A. Ostrander;Stella Koutros;L. B. Beane Freeman;M. Stampfer;A. Wolk;N. Håkansson;Gerald L. Andriole;R. N. Hoover;M. Machiela;K. D. Sørensen;Michael Borre;William J Blot;W. Zheng;E. Yeboah;James E Mensah;Yong;Hong;Ninghan Feng;Xueying Mao;Yudong Wu;Shan;Zan Sun;S N Thibodeau;S. McDonnell;D. Schaid;C. West;Gill Barnett;C. Maier;T. Schnoeller;Manuel Luedeke;A. Kibel;Bettina F Drake;O. Cussenot;G. Cancel;F. Menegaux;Thérèse Truong;Y. Koudou;Esther M John;E. Grindedal;L. Maehle;K. Khaw;S. Ingles;M. Stern;Ana Vega;A. Gómez;L. Fachal;B. Rosenstein;Sarah L. Kerns;H. Ostrer;Manuel R Teixeira;P. Paulo;Andreia Brandão;S. Watya;Alex Lubwama;J. Bensen;Eboneé N. Butler;James L Mohler;Jack A. Taylor;M. Kogevinas;T. Dierssen;G. Castaño‐Vinyals;L. Cannon;C. Teerlink;Chad D Huff;P. Pilié;Yao Yu;R. Bohlender;Jian Gu;Sara S. Strom;L. Multigner;P. Blanchet;L. Brureau;R. Kaneva;C. Slavov;V. Mitev;Robin J. Leach;H. Brenner;Xuechen Chen;Bernd Holleczek;B. Schöttker;Eric A Klein;A. Hsing;Rick A. Kittles;Adam B. Murphy;Christopher J. Logothetis;Jeri Kim;S. Neuhausen;L. Steele;Y. Ding;W. Isaacs;B. Nemesure;A. Hennis;J. Carpten;H. Pandha;Agnieszka Michael;K. De Ruyck;G. De Meerleer;P. Ost;Jianfeng Xu;A. Razack;Jasmine Lim;Soo;Lisa F. Newcomb;Daniel W. Lin;J. Fowke;C. Neslund;B. Rybicki;Marija Gamulin;D. Lessel;T. Kuliš;N. Usmani;A. Abraham;Sandeep Singhal;M. Parliament;Frank Claessens;Steven Joniau;T. Van den Broeck;M. Gago;J. Castelao;María Elena Martínez;Samantha E. T. Larkin;Paul A. Townsend;Claire Aukim;William S Bush;M. Aldrich;Dana C Crawford;S. Srivastava;Jennifer Cullen;G. Petrovics;G. Casey;Ying Wang;Y. Tettey;J. Lachance;Wei Tang;R. Biritwum;A. Adjei;Evelyn Tay;A. Truelove;S. Niwa;K. Yamoah;K. Govindasami;A. Chokkalingam;Jacob M. Keaton;J. Hellwege;Peter E. Clark;M. Jalloh;S. Gueye;L. Niang;O. Ogunbiyi;Olayiwola Shittu;O. Amodu;A. Adebiyi;O. Aisuodionoe;Hafees O Ajibola;M. Jamda;O. Oluwole;Maxwell Nwegbu;B. Adusei;S. Mante;Afua Darkwa;H. Diop;Susan M Gundell;M. Roobol;G. Jenster;Ron H N van Schaik;Jennifer J Hu;M. Sanderson;L. Kachuri;Rohit Varma;R. Mckean;M. Torres;Michael H. Preuss;R. Loos;M. Zawistowski;Sebastian Zöllner;Zeyun Lu;S. K. Van Den Eeden;D. Easton;S. Ambs;T. Edwards;R. Mägi;Timothy R Rebbeck;L. Fritsche;S. Chanock;S. I. Berndt;F. Wiklund;H. Nakagawa;John S. Witte;J. Gaziano;Amy C Justice;N. Mancuso;C. Terao;R. Eeles;Z. Kote;R. Madduri;David V Conti;C. Haiman
通讯作者：
C. Haiman

the genetic etiology

遗传病因学

DOI：
发表时间：
2024-09-14
期刊：
影响因子：
0
作者：
C. Bellenguez;L. Kleineidam;Amin Najaf Sonia;A. Naj;Grenier;Andrade Victor Holmans Peter A Benjamin;A. Bol;van der Lee Vincent;Costa Sven J.;Kuulasmaa Marcos R.;Carla Abdelnour;Alcolea Emilio;Alegret Daniel;Alvarez Ignacio Álvarez Victoria Armstrong Montserrat;Arosio Beatrice Athanasiu Lavinia Bailly Henri Banaj Neri Alfonso Arias;Below Ana Belén;Blesa Rafael Boada Mercè Boerwinkle Eric Borroni Barbara Aless;ra;Henry;Keeley J. Brookes;Luis Ignacio;Buiza;Katharina Burholt Vanessa Dolores Bûrger;William S Bush;Cantwell Miguel;Laura Cervera;C. Charbonnier;Hung;J. A. Claassen;A. Corma;Carolina;Daniele;Dardiotis Efthimios Dartigues Jean;D. Deyn;Peter Paul;Paiva Lopes;de Witte Lot D Katia;del Ser;Denning Teodoro;Nicola DeStefano;Dichgans Anita;Diez;Djurovic Srdjan Duron Emmanuelle Düzel Emrah Dufouil Carole Paolo Dionigi;Espinosa Valentina;Ewers Michael Faber Ana;Sune Fallgaard;D. Fardo;Fenoglio;Chiara;Harald Hanon Kara L Hampel;Hardy John Hartmann Annette M Olivier;Holmes Clive Holstege Henne Vilas Raquel Huerto Per;Seshadri Sudha Andreassen Ole A Giacomina;M. Ingelsson;Cornelia M. Van Duijn;R. Sims;W. M. van der Flier;Agustin Ruiz;Jean;A. Palotie;M. Daly;H. Jacob;A. Matakidou;H. Runz;S. John;R. Plenge;M. Mccarthy;J. Hunkapiller;Meg Ehm;D. Waterworth;Caroline Fox;A. Malarstig;K. Klinger;Kathy Call;tim Behrens;P. Loerch;T. Mäkelä;J. Kaprio;P. Virolainen;Kari Pulkki;Kilpi;M. Perola;J. Partanen;A. Pitkäranta;Kaarteenaho;S. Vainio;M. Turpeinen;R. Serpi;Tarja Laitinen;J. Mäkelä;V. Kosma;Kujala;Outi Tuovila;Minna Hendolin;Pakkanen;J. Waring;B. Riley;Jimmy Z Liu;Shameek Biswas;D. Diogo;C. Marshall;Xinli Hu;M. Gossel;Rob Graham;Beryl B. Cummings;S. Ripatti;J. Schleutker;Mikko Arvas;reetta Hinttala Olli carpén 347;J. Kettunen;A. Mannermaa;J. Laukkanen;Valtteri Julkunen;A. Remes;Kälviäinen;J. Peltola;P. Tienari;Juha O. Rinne;A. Ziemann;S. Esmaeeli;N. Smaoui;A. Lehtonen;Susan Eaton;S. Lahdenperä;J. Adelsberg;J. Michon;Geoff Kerchner;Natalie Bowers;John D. Eicher;Vinay Mehta;P. Gormley;K. Lindén;Christopher Whelan;Fanli Xu;D. Pulford;Martti A Färkkilä;S. Pikkarainen;A. Jussila;T. Blomster;M. Kiviniemi;M. Voutilainen;Bob Georgantas;Graham A. R. Heap;F. Rahimov;K. Usiskin;Tim Lu;D. Oh;Kirsi Kalpala;Melissa Miller;L. Mccarthy;Kari K Eklund;A. Palomäki;P. Isomäki;L. Pirilä;O. Kaipiainen;Johanna Huhtakangas;A. Lertratanakul;M. Hochfeld;N. Bing;J. Gordillo;N. Mars;Margit K. Pelkonen;P. Kauppi;H. Kankaanranta;Harju;David W. Close;Steven Greenberg;Hubert Chen;Jo Betts;Soumitra Ghosh;V. Salomaa;Niiranen;M. Juonala;K. Metsärinne;M. Kähönen;J. Junttila;Markku Laakso;J. Pihlajamäki;J. Sinisalo;M. Taskinen;Bennett Challis;Andrew Peterson;Audrey M. Chu;J. Parkkinen;Anthony Muslin;H. Joensuu;Meretoja;L. Aaltonen;Johanna Mattson;A. Auranen;P. Karihtala;S. Kauppila;P. Auvinen;K. Elenius;Popovic;J. Schutzman;Andrey Loboda;A. Chhibber;Heli J. Lehtonen;S. McDonough;Marika Crohns;Diptee A. Kulkarni;K. Kaarniranta;terhi Ollila Joni A. turunen 356;S. Seitsonen;Hannu Uusitalo;V. Aaltonen;H. Uusitalo;M. Luodonpää;N. Hautala;Stephanie Loomis;Erich Strauss;Hao Chen;Anna I. Podgornaia;Joshua Hoffman;K. Tasanen;L. Huilaja;K. Hannula;Salmi;S. Peltonen;L. Koulu;Harvima;Ying Wu;David Choy;P. Pussinen;A. Salminen;Salo;Dave Rice;Pekka Nieminen;U. Palotie;M. Siponen;L. Suominen;P. Mäntylä;Gursoy;V. Anttonen;K. Sipilä;J. Davis;D. Quarless;S. Petrovski;Eleonor Wigmore;Chia;P. Bronson;Ellen A. Tsai;Yunfeng Huang;Joseph C Maranville;Samir Wadhawan;E. Kvikstad;Minal caliskan;tushar Bhangale Diana chang 336;S. Pendergrass;E. Holzinger;Xing Chen;Å. Hedman;Karen S. King;C;E. Xu;F. Augé;C. Chatelain;D. Rajpal;Dongyu Liu;Kathy Call;Tai;Matt Brauer;M. Kurki;J. Karjalainen;A. Havulinna;A. Jalanko;P. Palta;Pietro della;Briotta Parolo;Wei Zhou;S. Lemmelä;M. Rivas;J. Harju;Arto A Lehisto;A. Ganna;V. Llorens;H. Laivuori;S. Rüeger;Mari E. K. Niemi;tukiainen 331;Mary Pat reeve 331;H. Heyne;Kimmo Palin;Javier Garcia;H. Siirtola;Kiiskinen;Jiwoo Lee;K. Tsuo;A. Elliott;K. Kristiansson;K. Hyvärinen;J. Ritari;Miika Koskinen;K. Pylkäs;Marita Kalaoja;Minna M. Karjalainen;Mantere;Kangasniemi;S. Heikkinen;Laakkonen;Sipeky;S. Heron;A. Karlsson;Dhanaprakash Jambulingam;V. Rathinakannan;Risto Kajanne;M. Aavikko;Manuel González Jiménez;Pietro della Briotta Parola;Arto Lehistö;M. Kanai;M. Kaunisto;Elina Kilpeläinen;P. Sipilä;Georg Brein;Ghazal Awaisa;Anastasia Shcherban;K. Donner;A. Loukola;P. Laiho;Sistonen;Kaiharju;Markku Laukkanen;Elina Järvensivu;S. Lähteenmäki;Lotta Männikkö;Wong;Hannele Mattsson;T. Hiekkalinna;Paajanen;K. Pärn;Javier Gracia;Martin Woon;B. Wright;chuang;S. Younkin;chang;Lei Yu;Yuanchao Zhang;Yi Zhao;Xiongwei Zhu
通讯作者：
Xiongwei Zhu