MEMORY MONITORING AND DECLARATIVE MEMORY IN MONKEYS: BEHAVIOR AND BRAIN

猴子的记忆监控和陈述性记忆：行为和大脑

• 批准号: 7958253
• 负责人: ROBERT L. HAMPTON
• 金额: $ 5.48万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958253
• 关键词: Age-associated memory impairment; Alzheimer' s Disease; Animal Model; Attention; Attention deficit hyperactivity disorder; Autistic Disorder; Behavior; Brain; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Decision Making; Funding; Grant; Human; Impaired cognition; Impulse Control Disorders; Institution; Learning; Letters; Location; Memory; Monitor; Monkeys; Persons; Primates; Process; Reporting; Research; Research Personnel; Resources; Source; Stroke; Structure; Testing; United States National Institutes of Health; improved; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The human ability to consciously monitor the contents of memory has not been accessible to study in animal models. Because humans talk about memories that are accessible to monitoring, such memories are called declarative. In contrast, nondeclarative memories cannot be subjectively monitored, but are inferred from their influence on behavior. For example, a person who may not be able to verbally report the locations of the letters on a keyboard may nonetheless type accurately and rapidly without looking at the keys. Loss of declarative memory from stroke, Alzheimer's disease, and other brain insults severely impairs higher cognitive processes including learning, planning, and adaptive decision-making. Memory monitoring is also a form of metacognition. Impaired metacognition is implicated in autism, age-related cognitive decline, and attention and impulse control disorders such as ADHD. Animal models are needed to identify the specific brain structures involved in memory monitoring and declarative memory so that we can develop improved treatments for cognitive impairment in humans. We have begun testing a new squad of monkeys for this recently funded project. We used a delayed-response task and are about to add a "decline-test" response to the task that will allow for assessment of metamemory.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 人类有意识地监测记忆内容物的能力尚未在动物模型中进行研究。由于人类谈论可用于监视的记忆，因此这种记忆称为宣告。相反，不能主观监控非分离的记忆，而是根据其对行为的影响来推断出来的。例如，一个可能无法口头报告键盘上字母的位置的人可能仍然可以准确，迅速地键入而无需查看键。失去了中风，阿尔茨海默氏病以及其他大脑侮辱的声明性记忆，严重损害了更高的认知过程，包括学习，计划和适应性决策。记忆监测也是元认知的一种形式。元认知受损与自闭症有关，与年龄相关的认知能力下降以及注意力和冲动控制障碍（如多动症）。需要动物模型来确定与记忆监测和声明性记忆中有关的特定大脑结构，以便我们可以改善人类认知障碍的治疗方法。 我们已经开始为这个最近资助的项目测试一支新的猴子小队。我们使用了延迟的响应任务，并将对将允许评估元符号评估的任务添加“下降测试”响应。