VISUAL PROCESSING IN CEREBRAL CORTEX

大脑皮层的视觉处理

• 批准号: 7958349
• 负责人: John H.R. Maunsell
• 金额: $ 6.49万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958349
• 关键词: Attention; Behavior; Cerebral cortex; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Institution; Lead; Mediating; Neurons; New England; Perception; Performance; Primates; Property; Research; Research Personnel; Resources; Sensory; Signal Transduction; Source; Testing; United States National Institutes of Health; Visual; attentional modulation; base; directed attention; neuromechanism; research study; response; visual process; visual processing

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Attention is a critical factor in sensory and cognitive performance. Problems in controlling and directing attention can lead to serious deficits in performance and behavior. More complete information about the neural mechanisms underlying attention will be important for understanding how it facilitates perception and guides behaviors. Our experiments will extend our understanding of the neuronal basis of attention by testing the hypothesis that attentional modulation depends on the same neuronal circuits that mediate sensory response normalization. Response normalization is a well-established mechanism that adjusts sensory signals based on the overall activity in a large group of neurons with similar response properties. We propose that attentional modulations in visual cerebral cortex act through this normalization mechanism, such that attentional modulation cannot occur in conditions when normalization is weak or eliminated. These experiments will provide a critical test of the hypothesis that attention depends on normalization mechanisms. In doing so they have the potential of greatly extending our understanding of the neural mechanisms that underlie attention.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 注意是感觉和认知表现的关键因素。 控制和指导注意力方面的问题可能导致绩效和行为的严重缺陷。 有关关注的神经机制的更完整的信息对于理解它如何促进感知和指导行为至关重要。 我们的实验将通过测试注意调制取决于介导感觉响应归一化的相同神经元电路的假设来扩展我们对注意力的神经元基础的理解。 响应归一化是一种完善的机制，它根据具有相似响应特性的大量神经元的整体活性来调整感觉信号。 我们提出，视觉脑皮质中的注意调制通过这种归一化机制起作用，因此当归一化较弱或消除时，注意力调制不可能发生。这些实验将对注意力取决于归一化机制的假设提供批判性检验。 通过这样做，他们有可能大大扩展我们对关注的神经机制的理解。