Innate Immunity: Mechanisms Linking with Adaptive Immunity

先天免疫：与适应性免疫相关的机制

• 批准号: 7916009
• 负责人: ANDREW D ROBERTSON
• 金额: $ 0.9万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7916009
• 关键词: Adjuvant; Autoimmune Process; B-Cell Development; Back; CD80 gene; Communicable Diseases; Complex; Dendritic Cells; Disease; Feedback; Host Defense; Immune; Immune Response Genes; Immune system; Immunity; Immunologic Receptors; Inflammatory; Inflammatory Response; Ireland; Link; Memory; Microbe; Molecular; Natural Immunity; Nucleic Acids; Play; Research Personnel; Role; Scientist; Signal Pathway; Surface; Therapeutic; Toll-like receptors; Transcriptional Regulation; Translating; Work; adaptive immunity; base; cytokine; insight; interest; meetings; microbial; novel; pathogen; receptor; response; symposium

DESCRIPTION (provided by applicant): This proposal is to request support for a Keystone Symposia meeting entitled Innate Immunity: Mechanisms Linking with Adaptive Immunity, organized by Luke A.J. O'Neill, Kate A. Fitzgerald and Averil I. Ma, which will be held in Dublin, Ireland from June 7 - 12, 2010. In the past 5 years there have been remarkable advances in our understanding of the molecular basis of innate immunity. We now have considerable detail on the major classes of innate immune receptors that sense pathogens and provoke immune and inflammatory responses. These include the Toll-like receptors (TLRs), NOD-like receptors (NLRs) and RIG-I-like receptors (RLRs). The role these receptors play in host defense against microbes has been studied, their signaling pathways elucidated, and their roles in infectious and inflammatory diseases examined in detail. As well as stimulating innate immunity via induction of various effector mechanisms, these receptors also participate in the establishment of adaptive immunity. This occurs via the induction of key cytokines to promote T and B cell development and activation, and also via the induction of co-stimulatory molecules on the surface of dendritic cells, notably CD80 and CD86. A final aspect concerns adjuvancy - microbial or synthetic agents that activate these receptors act as powerful adjuvants required for the establishment of memory responses. The interface between innate and adaptive immunity continues to reveal novel components and mechanisms which might ultimately lend themselves to therapeutic manipulation. New receptors that sense pathogens (particularly nucleic acids) and the mechanisms that activate them are being uncovered. Negative feedback loops from adaptive immunity back to innate immunity are being revealed. Evolutionary aspects are also providing insights into how the complex mammalian immune system was formed. This conference will bring together scientists working on innate immune mechanisms activated by these receptors, and will have as a key focus the ability of these receptors and the responses they elicit to promote adaptive immunity. The conference will therefore be of interest to many investigators interested in immunity and the role the immune system plays in disease. Considerable progress has been made in recent years in our understanding of how microbial invaders are recognized by the innate immune system and how sensing translates into signaling pathways that culminate in the transcriptional regulation of immune response genes. The Keystone Symposia meeting on Innate Immunity: Mechanisms Linking with Adaptive Immunity will bring together world-renowned scientists working on innate immune sensing mechanisms and adaptive immunity, and will be of interest to researchers investigating immunity, infectious disease and the role the immune system plays in autoimmune and inflammatory diseases.

描述（由申请人提供）：该提案是为了支持Keystone研讨会会议，标题为“先天免疫：与自适应免疫相关的机制，由Luke A.J.组织O'Neill，Kate A. Fitzgerald和Averil I. Ma，将于2010年6月7日至12日在爱尔兰的都柏林举行。在过去的5年中，我们对先天免疫的分子基础的理解取得了显着进步。现在，我们对具有病原体和引发免疫和炎症反应的主体免疫受体的主要类别有相当大的细节。这些包括Toll样受体（TLR），点状受体（NLR）和RIG-I样受体（RLR）。这些受体在针对微生物的宿主防御中的作用，阐明了它们的信号通路，以及它们在详细检查的感染性和炎症性疾病中的作用。除了通过诱导各种效应器机制刺激先天免疫，这些受体还参与了自适应免疫的建立。这是通过诱导关键细胞因子来促进T和B细胞发育和激活的原因，也是通过在树突状细胞表面（特别是CD80和CD86）诱导共刺激分子的诱导。最终方面涉及佐剂 - 激活这些受体的微生物或合成剂充当建立记忆反应所需的强大佐剂。先天免疫和适应性免疫之间的界面继续揭示新的组成部分和机制，最终可能使自己用于治疗性操纵。发现病原体（尤其是核酸）及其激活它们的机制的新受体正在被发现。正在揭示从自适应免疫力回到先天免疫力的负反馈回路。进化方面还提供了有关如何形成复杂的哺乳动物免疫系统的见解。这次会议将汇集研究这些受体激活的先天免疫机制的科学家，并将这些受体的能力及其引起的促进适应性免疫的反应作为关键。因此，许多对免疫感兴趣的调查人员以及免疫系统在疾病中所起的作用将引起会议。近年来，在我们对微生物入侵者如何被先天免疫系统识别的方式以及传感如何转化为最终在免疫反应基因转录调节中的信号通路方面取得了长足进展。 Keystone先天免疫性会议会议：与适应性免疫联系起来的机制将使世界知名的科学家致力于先天免疫感应机制和适应性免疫，并将对研究人员感兴趣，研究人员对免疫性，感染性疾病以及免疫系统在自身免疫性和炎症性疾病中起着作用。