Functional Brain Reorganization in stroke Recovery

中风恢复中的功能性大脑重组

• 批准号: 7545438
• 负责人: ANDREW C. PAPANICOLAOU
• 金额: $ 118.19万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7545438
• 关键词: Functional; Brain; Reorganization; stroke; Recovery

The process of recovery of basic sensory, motor, and higher cognitive and linguistic functions, following stroke, is not well understood. Also poorly understood are the neurophysiological mechanisms that mediate the effectiveness of therapies, like the Constraint-Induced Therapy (CIT), which are reputed to enhance the recovery process. It has been suggested, however, that, fundamentally, recovery is a result of functional reorganization of the brain. Before the advent of functional neuroimaging, evidence supporting this notion consisted entirely of indirect inferences from clinical or behavioral data. Recently, however, we and others, using Magnetoencephalography (MEG) and other functional neuroimaging methods, have begun accumulating direct evidence of brain plasticity and functional reorganization. In this Program Project we plan to investigate systematically the extent and type of reorganization, using MEG-derived brain activation profiles, during spontaneous recovery from stroke, of the following behavioral and cognitive functions: First, expressive and receptive language; second, motor; and third, somatosensory and spatial attention functions. We also plan to study the effects of CIT used to enhance the recovery process of language and sensorimotor functions, on these activation profiles. We expect that the extent and type of reorganization observed will vary as a function of lesion parameters, assessed through structural MRI, and neuropsychological testing. Finally, we will attempt to specify the repercussions of reorganization of the mechanisms of the compromised functions for the mechanisms of functions unaffected by the stroke using, once again, MEG mapping.

尚未充分了解基本感觉，运动以及更高的认知和语言功能的恢复过程。介导疗法的有效性的神经生理机制也很熟悉，例如约束诱导的治疗（CIT），这些疗法旨在增强恢复过程。但是，从根本上讲，恢复是大脑功能重组的结果。在功能性神经影像出现之前，支持该概念的证据完全由临床或行为数据的间接推论组成。然而，最近，我们和其他人使用磁脑电图（MEG）和其他功能性神经影像学方法已经开始 累积直接证据的大脑可塑性和功能重组。在此计划项目中，我们计划在从中风自发恢复期间，使用MEG衍生的大脑激活曲线系统地研究重组的程度和类型，以下行为和认知功能：首先，表达和接受语言；第二，电动机；第三，体感和空间注意力功能。我们还计划研究用来增强语言和感觉运动功能恢复过程对这些激活曲线的恢复过程的效果。我们预计观察到的重组程度和类型将随着病变参数的函数而变化，通过结构MRI和神经心理学测试进行评估。最后，我们将尝试指定折衷函数机理的重组的影响，以再次使用中风映射的函数机制，而不是中风映射。

项目成果

Aberrant cortical functionality and somatosensory deficits after stroke.

中风后皮质功能异常和体感缺陷。

• DOI: 10.1097/wnp.0b013e318176c0d4
• 发表时间: 2008
• 期刊: Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society
• 作者: Castillo,EduardoM;Boake,Corwin;Breier,JoshuaI;Men,Disheng;Garza,HectorM;Passaro,Anthony;Papanicolaou,AndrewC
• 通讯作者: Papanicolaou,AndrewC

Magnetoencephalographic studies of language reorganization after cerebral insult.

脑损伤后语言重组的脑磁图研究。

• DOI: 10.1016/j.apmr.2006.07.271
• 发表时间: 2006
• 期刊: Archives of physical medicine and rehabilitation
• 影响因子: 4.3
• 作者: Breier,JoshuaI;Billingsley-Marshall,Rebecca;Pataraia,Ekaterina;Castillo,EduardoM;Papanicolaou,AndrewC
• 通讯作者: Papanicolaou,AndrewC

Behavioral and neurophysiologic response to therapy for chronic aphasia.

• DOI: 10.1016/j.apmr.2009.08.144
• 发表时间: 2009-12
• 期刊: ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
• 影响因子: 4.3
• 作者: Breier, Joshua I.;Juranek, Jenifer;Maher, Lynn M.;Schmadeke, Stephanie;Men, Disheng;Papanicolaou, Andrew C.
• 通讯作者: Papanicolaou, Andrew C.

What is the evidence for use dependent learning after stroke?

中风后使用依赖学习的证据是什么？

• DOI: 10.1161/strokeaha.108.534925
• 发表时间: 2009
• 期刊: Stroke
• 影响因子: 8.3
• 作者: Kent,ThomasA;Rutherford,DevonG;Breier,JoshuaI;Papanicoloau,AndrewC
• 通讯作者: Papanicoloau,AndrewC

MEG correlates of bimodal encoding of faces and persons' names.

MEG 关联人脸和人名的双峰编码。

• DOI: 10.1016/j.brainres.2008.07.003
• 发表时间: 2008
• 期刊: Brain research
• 影响因子: 2.9
• 作者: Pazo-Alvarez,P;Simos,PG;Castillo,EM;Juranek,J;Passaro,AD;Papanicolaou,AndrewC
• 通讯作者: Papanicolaou,AndrewC