MEG of Somatosensory & Attentional Processes

体感MEG

• 批准号: 6883892
• 负责人: ANDREW C. PAPANICOLAOU
• 金额: $ 43.93万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6883892
• 关键词: attention; behavior test; bioimaging /biomedical imaging; cerebral ischemia /hypoxia; functional ability; human middle age (35-64); human subject; magnetic resonance imaging; magnetoencephalography; neural plasticity; neuropsychological tests; neuropsychology; patient oriented research; psychometrics; rehabilitation; somesthetic sensory cortex; stroke; visual stimulus; attention; behavior test; bioimaging /biomedical imaging; cerebral ischemia /hypoxia; functional ability; human middle age (35-64); human subject; magnetic resonance imaging; magnetoencephalography; neural plasticity; neuropsychological tests; neuropsychology; patient oriented research; psychometrics; rehabilitation; somesthetic sensory cortex; stroke; visual stimulus

The objective of this proposal is to address the question of how changes in cortical activity that follow ischemic insult are related to functional improvement of somatosensory and attentional processes. In order to meet this objective, we will specify the parameters of cerebral reorganization underlying recovery of somatosensory and attentional functions in patients with unilateral ischemic stroke using magnetoencephalography (MEG). We will then determine the correspondence between MEG parameters of reorganization and relevant behavioral measures of recovery of function. In addition, we will outline the relation between stroke lesion variables (volume and location) and MEG-based indices of reorganization, as well as between lesion variables and behavioral measures of functional recovery. An understanding of cortical mechanisms of recovery and reorganization will help determine prognosis and optimal treatment for individuals recovering from somatosensory and attentional deficits following cortical infarction. The study design includes a baseline behavioral and neuropsychological assessment followed by MEG and MRI imaging at 2-3 months and 10-12 months post-stroke. We will obtain spatiotemporal MEG maps of brain activity associated with stimulation of the fingertips of both hands in patients with current or prior hemianesthesia at these two time intervals. A subset of these patients will have undergone constraint-induced therapy (CIT) and will be compared with control participants who have been treated with standard care therapy. We will also obtain spatiotemporal maps of cortical activity associated with selective attention to visual stimuli in patients recovering or recovered from unilateral neglect (with or without hemianesthesia) over the same time interval. Changes in MEG parameters (anatomical location, magnitude, and time course of the event-related magnetic response) will establish the nature and extent of reorganization in relation to behavioral and cognitive recovery. The relations between these parameters and detailed volumetric analyses of structural MRIs obtained at the same time periods will reveal associations between stroke type and cortical reorganization related to recovery.

该提案的目的是解决以下问题的问题，即缺血性损伤的皮质活动变化与体感和注意力过程的功能改善有关。为了实现这一目标，我们将使用磁脑表表（MEG）的单侧缺血性中风患者指定体感和注意力功能的脑重组的参数。然后，我们将确定重组的MEG参数与功能恢复的相关行为度量之间的对应关系。此外，我们将概述中风病变变量（体积和位置）与基于MEG的重组指数之间的关系，以及病变变量与功能恢复的行为度量之间的关系。对恢复和重组的皮质机制的理解将有助于确定皮质梗塞后体感和注意力缺陷恢复的个体的预后和最佳治疗方法。研究设计包括基线行为和神经心理学评估，然后在冲程后2-3个月和10-12个月时进行MEG和MRI成像。在这两个时间间隔内，我们将获得与当前或先前半休息患者刺激双手指尖有关的大脑活动的时空MEG图。这些患者的一部分将接受约束诱导的治疗（CIT），并将与接受过标准护理疗法治疗的对照参与者进行比较。我们还将获得与从单方面疏忽恢复或恢复的患者（有或没有半含量）的患者中选择性关注视觉刺激相关的皮质活性的时空图。 在同一时间间隔内。 MEG参数的变化（解剖位置，与事件相关的磁反应的时间过程）将建立与行为和认知恢复有关的重组的性质和程度。这些参数与在同一时期获得的结构MRI的详细体积分析之间的关系将揭示与恢复相关的中风类型与皮质重组之间的关联。