Northern New England Clinical and Translational Research Network

新英格兰北部临床和转化研究网络

基本信息

批准号：
10681809
负责人：
CLIFFORD JAMES ROSEN
金额：
$ 136.41万
依托单位：
MAINEHEALTH
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-07 至 2024-09-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10681809
关键词：
Acceleration Acute Address Aging American Area Atherosclerosis Award Biometry COVID-19 COVID-19 pandemic Cardiovascular Diseases Centers of Research Excellence Chronic Clinical Data Clinical Investigator Clinical Research Clinical Trials Collaborations Communication Communities Community Health Community Outreach Coupled Cultural Diversity Data Development Diabetes Mellitus Disease Education Environment Epidemiology Evaluation Extramural Activities Faculty Foundations Funding Funding Mechanisms Goals Governing Board Grant Health Healthcare Human Papilloma Virus Vaccine Human Resources Immigrant Infrastructure Institution Leadership Learning Link Maine Malignant Neoplasms Mentors Mentorship Modeling Native Americans New England New Hampshire Obesity Opiate Addiction Opioid Passamaquoddy Tribe of Maine Patient Care Peer Review Penobscot Pilot Projects Play Population Populations at Risk Post-Acute Sequelae of SARS-CoV-2 Infection Predisposition Primary Care Public Health Publications Registries Research Research Design Research Infrastructure Research Personnel Research Support Reservations Resource Sharing Resources Role Rural Rural Health Rural Population Services Site Substance Use Disorder Substance abuse problem Technology Toxic Environmental Substances Training Training Programs Translational Research Tribes United States Health Resources and Services Administration United States National Institutes of Health Universities Urban Population Vermont career clinical investigation cohort community based research community engagement community involvement coronavirus disease equity, diversity, and inclusion flexibility food insecurity health communication health difference health disparity health equity improved innovation learning progression novel novel strategies patient oriented post-COVID-19 practice-based research network primary care practice programs rurality suburban communities technical report telehealth underserved community urban underserved vaccine hesitancy

项目摘要

The long-term goal of the Northern New England Clinical and Translational Research Network (NNE-CTR), composed of MaineHealth, the University of Vermont, and the University of Southern Maine, is to sustain a clinical and translational research infrastructure that supports improvements in community health for northern New England inhabitants. Maine and Vermont have the oldest populations in the U.S. and that, coupled with rurality, predisposes residents to a range of disorders ranging from cancer to substance use disorders, food insecurity, obesity, diabetes and cardiovascular disease. In addition, northern New England has a growing underserved immigrant population, as well as a Native American population. Our communities have been challenged by the Covid-19 pandemic, and we are addressing these challenges by linking primary care practice centers with academic centers and developing innovative approaches to community-based research. During our first four years, the NNE-CTR has built a strong foundation for clinical research. We partnered with the oldest regional practice-based research network (PBRN), the Dartmouth Co-Op, and actively supported successful NIH program applications, including two COBREs, two NCI program grants, an infrastructure grant for a new Center for Biomedical Shared Resources, and a HRSA grant to build on the opioid treatment model pioneered in Vermont. The NNE-CTR PI is playing a leadership role in coordinating a national CTR network, including the CTR National COVID Cohort Collaborative (N3C), a registry to share clinical data on Covid-19 nationally, and the NIH-sponsored RECOVER trial, which will define the long-term sequelae of Covid-19. In this renewal, we plan to expand our collaborations both regionally and nationally, strengthen our PBRN, and embrace cultural diversity. We will strengthen Core resources that include: the Biostatistics, Epidemiology and Research Design Core, which will improve data capability and research navigation services; the Professional Development Core, which will offer an array of new educational and mentorship opportunities; the Pilot Projects Program, which will provide new and flexible funding mechanisms to offer more support for community-based projects; the Translational Research and Technology Core, offering state-of-the-art technologies and training for new investigators, and the Community Engagement and Outreach Core, which will build stronger bridges to underserved communities. We propose three specific aims: 1-Expand infrastructure and resources to address clinical and translational research needs in northern New England; 2- Strengthen clinical and translational research that addresses health equity and disparities encountered by at- risk populations, including expansion of clinical trial access, telehealth, and mentored training programs for new investigators; and 3-Accelerate regional and national collaborative initiatives within the IDeA networks and through NIH such as N3C and RECOVER. In sum, we will strengthen the NNE-CTR through continuous learning and improvement supported by the principles of diversity, inclusion, and equity.

北新英格兰临床和转化研究网络（NNE-CTR）的长期目标，由 MaineHealth、佛蒙特大学和南缅因大学组成，旨在维持支持改善北部社区健康的临床和转化研究基础设施新英格兰居民。缅因州和佛蒙特州拥有美国最古老的人口，再加上农村地区的居民容易患上一系列疾病，从癌症到药物滥用、食物不安全感、肥胖、糖尿病和心血管疾病。此外，新英格兰北部也有不断增长的服务不足的移民人口以及美洲原住民人口。我们的社区已经受到 Covid-19 大流行的挑战，我们正在通过将初级保健联系起来来应对这些挑战实践中心与学术中心，并开发基于社区的研究的创新方法。在最初的四年里，NNE-CTR 为临床研究奠定了坚实的基础。我们与以下机构合作：最古老的区域性基于实践的研究网络（PBRN），达特茅斯合作社，并得到积极支持成功的 NIH 计划申请，包括两项 COBRE、两项 NCI 计划拨款、一项基础设施拨款建立一个新的生物医学共享资源中心，以及建立阿片类药物治疗模型的 HRSA 拨款首创于佛蒙特州。 NNE-CTR PI 在协调国家 CTR 网络方面发挥着领导作用，包括 CTR National COVID Cohort Collaborative (N3C)，这是一个共享 Covid-19 临床数据的注册中心以及 NIH 赞助的 RECOVER 试验，该试验将确定 Covid-19 的长期后遗症。在此次更新，我们计划扩大区域和国家范围内的合作，加强我们的 PBRN，以及拥抱文化多样性。我们将加强核心资源，包括：生物统计学、流行病学和研究设计核心，将提高数据能力和研究导航服务；专业人士发展核心，将提供一系列新的教育和指导机会；飞行员项目计划，将提供新的、灵活的资助机制，为以社区为基础的项目；转化研究和技术核心，提供最先进的为新研究者提供技术和培训，以及社区参与和外展核心，将为服务欠缺的社区建立更牢固的桥梁。我们提出三个具体目标： 1-扩展满足新英格兰北部临床和转化研究需求的基础设施和资源； 2- 加强临床和转化研究，解决健康公平问题和以下人群遇到的差异：风险人群，包括扩大临床试验机会、远程医疗和指导培训计划新调查员； 3-加速 IDeA 网络内的区域和国家合作举措以及通过 NIH，例如 N3C 和 RECOVER。总而言之，我们将通过不断加强 NNE-CTR 在多样性、包容性和公平原则的支持下学习和进步。