Whole Body Effects of PAE Across the Life Span: Early Markers of & Clinical Interventions for Children and Adolescents in Ukraine

PAE 对整个生命周期的全身影响：早期标志

• 批准号: 10682611
• 负责人: CHRISTINA CHAMBERS
• 金额: $ 52.6万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-12 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10682611
• 关键词: 10 year old; 14 year old; 4 year old; Address; Adolescent; Adult; Affect; Age; Alcohols; Anxiety; Atherosclerosis; Autoimmune Diseases; Biological Assay; Birth; Blood capillaries; Blood specimen; Burn injury; Cardiovascular Diseases; Cardiovascular Manifestation; Caregivers; Caring; Categories; Characteristics; Child; Childhood; Chronic Disease; Clinical; Clinical Data; Cohort Studies; Collaborations; Communities; Complex; Core Facility; Data; Diabetes Mellitus; Diagnosis; Diagnostic; Diet Habits; Dietary intake; Disease; Eating Behavior; Evaluation Studies; Family; Fetal Alcohol Exposure; Fetal Alcohol Spectrum Disorder; Fetal Alcohol Syndrome; Fetal alcohol effects; Future; Goals; Growth; Guidelines; Health Care Costs; Health system; Hearing; Hyperlipidemia; Hypertension; Impaired cognition; Individual; Inflammation; Insulin Resistance; Intervention; Knowledge; Laboratories; Length; Life; Life Cycle Stages; Longevity; Longitudinal cohort study; Measurement; Measures; Mediating; Mental Depression; Metabolic; MicroRNAs; Myocardial dysfunction; Nail plate; Outcome; Participant; Pattern; Physical activity; Premature aging syndrome; Prevalence; Prevention; Probability; Recommendation; Research; Research Personnel; Resources; Sample Size; Sampling; Signs and Symptoms; Sleep; Sleep disturbances; Structure; Telemedicine; Telomere Shortening; Three-Dimensional Image; Translating; Ukraine; Vision; Work; adverse childhood events; age group; capillary bed; cohort; comorbid depression; comorbidity; coping; developmental disease; disease classification; fetal diagnosis; impaired glucose tolerance; improved; inflammatory marker; iron deficiency; pre-clinical; prenatal; prevent; recruit; remediation; research clinical testing; telomere

Project Summary Numerous comorbidities have been identified as relatively common among children and adolescents with prenatal alcohol exposure (PAE) or fetal alcohol spectrum disorders (FASDs) including sleep disturbances, hypertension, abnormal eating behaviors, altered growth patterns, and comorbid depression and anxiety. In addition, emerging data suggest that several adult diseases of developmental origin, such as diabetes, atherosclerosis, cardiovascular and autoimmune disorders are over-represented and have earlier age at onset in adults with FASDs. It is imperative to better understand the prevalence and co-occurrence of these disorders as early as possible in the life course of children and adolescents with PAE, ideally at the sub-clinical stage, in order to intervene in clinically meaningful ways. Building on the existing Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD) longitudinal cohort study in Ukraine, we aim to fill this critical gap in knowledge in two ways. First, we will compare the prevalence and characteristics of subclinical and clinical signs/symptoms of current and developing metabolic and other chronic diseases and contributing factors in 180 children/adolescents with PAE age-matched to 120 children/adolescents with no/minimal PAE. This includes comparing prevalence of premorbid or comorbid hypertension, hyperlipidemia, impaired glucose tolerance/insulin resistance, and cardiovascular disease and also comparing growth parameters, physical activity, dietary intake, adverse childhood experiences, sleep disturbances, and measures of anxiety and depression. Second, we will compare findings on a panel of experimental measures of structure or function that can help illuminate mechanisms of PAE-related comorbidities across the lifespan in the same cohort of 300 children and adolescents. Experimental measures include capillary microvasculature, telomere length, and patterns of miRNA expression. Findings that are actionable will translate on the individual level to clinical guidance provided to the participant and caregiver. Furthermore, in keeping with one of the primary goals of CIFASD5, findings of this study will directly inform future intervention targets in children and adolescents to help remediate, ameliorate or prevent progression of pre-clinical or clinical conditions identified in the study evaluations. We will also work collaboratively with other investigators in the CIFASD Consortium to interactively address the overall goals of the Consortium in improving diagnosis and treatment of FASD.

项目概要 许多合并症已被确定在儿童和青少年中相对常见 产前酒精暴露 (PAE) 或胎儿酒精谱系障碍 (FASD)，包括睡眠障碍、 高血压、异常饮食行为、生长模式改变以及共病抑郁和焦虑。在 此外，新出现的数据表明，一些发育起源的成人疾病，如糖尿病、 动脉粥样硬化、心血管疾病和自身免疫性疾病的发病率较高，且发病年龄较早 患有 FASD 的成年人。必须更好地了解这些疾病的患病率和同时发生 在患有 PAE 的儿童和青少年的生命过程中尽早进行治疗，最好是在亚临床阶段， 以便以有临床意义的方式进行干预。以现有的胎儿酒精合作倡议为基础 乌克兰频谱障碍（CIFASD）纵向队列研究，我们的目标是填补这一关键知识空白 两种方式。首先，我们将比较亚临床和临床体征/症状的患病率和特征 第 180 章 患有 PAE 的儿童/青少年与 120 名没有/轻微 PAE 的儿童/青少年年龄匹配。这包括 比较病前或合并症高血压、高脂血症、血糖异常的患病率 耐受性/胰岛素抵抗和心血管疾病，还比较生长参数、身体状况 活动、饮食摄入、不良童年经历、睡眠障碍以及焦虑和焦虑的测量 沮丧。其次，我们将比较一组结构或功能实验测量的结果， 可以帮助阐明同一组 300 人在整个生命周期中 PAE 相关合并症的机制 儿童和青少年。实验测量包括毛细血管微血管系统、端粒长度和 miRNA 表达模式。可行的研究结果将在个人层面转化为临床 向参与者和护理人员提供指导。此外，为了与主要目标之一保持一致 CIFASD5，这项研究的结果将直接告知未来儿童和青少年的干预目标，以帮助 补救、改善或预防研究中确定的临床前或临床状况的进展 评价。我们还将与 CIFASD 联盟的其他研究人员合作，以互动方式 解决联盟在改善 FASD 诊断和治疗方面的总体目标。

项目成果

Baseline heart rate in infants with prenatal alcohol exposure: A systematic review and independent analysis.

产前酒精暴露婴儿的基线心率：系统评价和独立分析。

• 发表时间: 2023-03-01
• 影响因子: 2.1
• 作者: McDonnell, Peyton;Fornell, Pia;Ponce, Sarah;Dyer, Laura
• 通讯作者: Dyer, Laura

Prenatal alcohol exposure contributes to negative pregnancy outcomes by altering fetal vascular dynamics and the placental transcriptome.

产前酒精暴露会改变胎儿血管动力学和胎盘转录组，从而导致不良妊娠结局。

• 发表时间: 2022-06
• 作者: Pinson, Marisa R;Tseng, Alexander M;Adams, Amy;Lehman, Tenley E;Chung, Karen;Gutierrez, Jessica;Larin, Kirill V;Chambers, Christina;Miranda, Rajesh C;Collaborative Initiative on Fetal Alcohol Spectrum Disorders
• 通讯作者: Collaborative Initiative on Fetal Alcohol Spectrum Disorders

Maternal circulating miRNAs contribute to negative pregnancy outcomes by altering placental transcriptome and fetal vascular dynamics.

母体循环 miRNA 通过改变胎盘转录组和胎儿血管动力学导致不良妊娠结局。

• 发表时间: 2023
• 影响因子: 3.7
• 作者: Pinson, Marisa R;Tseng, Alexander M;Lehman, Tenley E;Chung, Karen;Gutierrez, Jessica;Larin, Kirill V;Chambers, Christina D;Miranda, Rajesh C;CIFASD
• 通讯作者: CIFASD

Wireless Heart Sensor for Capturing Cardiac Orienting Response for Prediction of Neurodevelopmental Delay in Infants.

用于捕获心脏定向反应以预测婴儿神经发育迟缓的无线心脏传感器。

• 发表时间: 2022-11-25
• 作者: Aguilar;Kable, Julie A;Yevtushok, Lyubov;Kulikovsky, Yaroslav;Zymak;Dubchak, Iryna;Akhmedzhanova, Diana;Wertelecki, Wladimir;Chambers, Christina;Coleman, Todd P
• 通讯作者: Coleman, Todd P

Vitamin D and maternal and child health: overview and implications for dietary requirements.

维生素 D 与孕产妇和儿童健康：膳食需求概述和影响。

• 发表时间: 2013-03
• 作者: Uriu;Obican, Sarah G;Keen, Carl L
• 通讯作者: Keen, Carl L