The Healthy Brain and Child Development National Consortium Administrative Core

健康大脑和儿童发展国家联盟行政核心

• 批准号: 10380522
• 负责人: CHRISTINA CHAMBERS
• 金额: $ 584万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10380522
• 关键词: 10 year old; Accountability; Address; Adult; Affect; Alcohols; Behavioral; Bioinformatics; Biological; Biological Factors; Birth; Brain; Child; Child Development; Childhood; Cohort Studies; Collaborations; Collection; Communication; Communities; Complement; Complex; Consultations; DNA; Data; Data Collection; Data Coordinating Center; Data Set; Decision Making; Development; Electronic Health Record; Enrollment; Ensure; Environment; Environmental Exposure; Environmental Hazards; Environmental Risk Factor; Epidemiology; Ethics; Exposure to; Genes; Goals; Health; Infant; Intervention; Investigation; Leadership; Legal; Life; Link; Location; Maps; Marijuana; Maternal Health; Measures; Modality; Modification; Monitor; Mothers; Opioid; Participant; Performance; Personal Satisfaction; Persons; Physiological; Policies; Population; Pregnancy; Pregnant Women; Process; Protocols documentation; Psychopathology; Public Policy; Publications; Questionnaires; Reproducibility; Research; Research Design; Research Personnel; Resource Sharing; Sampling; Site; Standardization; Stress; Structural Racism; Technology; Time; Tobacco; Toxicant exposure; Training; United States National Institutes of Health; Vulnerable Populations; Woman; Work; base; brain health; cohort; critical period; data harmonization; design; early experience; equity diversity and inclusion; experience; fetal substance exposure; hazard; health disparity; high dimensionality; high risk; improved; infancy; innovation; longitudinal dataset; magnetic resonance imaging/electroencephalography; maltreatment; meetings; neurobehavioral; neurodevelopment; neuroimaging; neurophysiology; performance site; physical conditioning; postnatal; prenatal; prospective; psychologic; racial and ethnic; recruit; resilience; socioeconomics; substance use; success; tool; training opportunity; wearable sensor technology; website development

PROJECT SUMMARY Neurodevelopmental processes are shaped by dynamic interactions between genes and environments. Maladaptive experiences early in life can alter developmental trajectories, leading to harmful and enduring developmental sequelae. Pre- and postnatal hazards include maternal substance exposure, toxicant exposures in pregnancy and early life, maternal health conditions, parental psychopathology, maltreatment, structural racism, and excessive stress. To elucidate how various environmental hazards impact child development, it is imperative that a normative template of developmental trajectories over the first 10 years of life be established based on a sufficiently large and demographically diverse sample of the US population. To accomplish this, the Healthy Brain and Child Development National Consortium study (HBCD) under the leadership and management of the HBCD National Consortium Administrative Core (HCAC) will deploy a harmonized, optimized, and innovative set of neuroimaging (MRI, EEG) measures complemented by an extensive battery of behavioral, physiological, and psychological tools, and biospecimens to understand neurodevelopmental trajectories in a sample of 7,500 mothers and infants enrolled at sites across the US. The overarching goal of the HBCD is to create a comprehensive, harmonized, and high-dimensional dataset that will characterize typical neurodevelopmental trajectories in US children and that will assess how biological and environmental exposures affect those trajectories. A special emphasis will be placed on understanding the impact of pre- and postnatal exposure to opioids, marijuana, alcohol, tobacco and/or other substances. To address these broad objectives, the HCAC will oversee study design, development of the common protocol, and monitor recruitment and retention to ensure that the sample of women enrolled includes: 1) a racially, ethnically, and socioeconomically diverse cohort that is representative of the US population; 2) pregnant woman with use of targeted substances (opioids, marijuana, alcohol, tobacco); and 3) demographically and behaviorally similar women without substance use in pregnancy to enable valid causal inferences. The HCAC will ensure study objectives are met, monitor performance, provide for training, establish and carry out decision-making and ethical policies, manage all study communications, and oversee processes for considering study modifications. In collaboration with the HBCD National Consortium Data Coordinating Center (HDCC), the HCAC will ensure that approximately annual study datasets are released to the broader scientific community. The HBCD National Consortium study will inform public policy to improve the health and development of children across the nation.

项目概要 神经发育过程是由基因和环境之间的动态相互作用决定的。 生命早期的适应不良经历会改变发展轨迹，导致有害和持久的 发育后遗症。产前和产后危害包括母体物质暴露、有毒物质暴露 怀孕和早年、孕产妇健康状况、父母精神病理学、虐待、结构性 种族主义和过度压力。为了阐明各种环境危害如何影响儿童发展， 必须建立生命头 10 年发展轨迹的规范模板 基于足够大且人口多样化的美国人口样本。为了实现这一目标， 健康大脑与儿童发展国家联盟研究（HBCD）领导和管理 HBCD 国家联盟管理核心 (HCAC) 将部署一个协调、优化和 一套创新的神经影像（MRI、EEG）测量方法，辅以广泛的行为、 生理、心理工具和生物样本，以了解神经发育轨迹 在美国各地注册的 7,500 名母亲和婴儿中进行了抽样调查。 HBCD 的总体目标是 创建一个全面、协调和高维的数据集，该数据集将表征典型的 美国儿童的神经发育轨迹，并将评估生物和环境暴露如何 影响这些轨迹。将特别强调了解产前和产后的影响 接触阿片类药物、大麻、酒精、烟草和/或其他物质。为了实现这些广泛的目标， HCAC 将监督研究设计、共同方案的制定，并监督招募和 保留，以确保登记的女性样本包括： 1) 种族、民族和社会经济特征 代表美国人口的多元化群体； 2) 使用目标物质的孕妇 （阿片类药物、大麻、酒精、烟草）； 3）人口统计和行为上相似的女性，但没有 怀孕期间的物质使用，以实现有效的因果推论。 HCAC 将确保实现研究目标， 监控绩效、提供培训、建立和执行决策和道德政策、管理 所有研究沟通，并监督考虑研究修改的流程。与合作 HBCD 国家联盟数据协调中心 (HDCC)，HCAC 将确保大约每年 研究数据集被发布给更广泛的科学界。 HBCD 国家联盟研究将提供信息 改善全国儿童健康和发展的公共政策。