The impact of COVID-19 pandemic-related stressors on childhood obesity and cardiometabolic risk

COVID-19 大流行相关压力源对儿童肥胖和心脏代谢风险的影响

基本信息

批准号：
10706570
负责人：
Alicia S Kunin-Batson
金额：
$ 67.01万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-19 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10706570
关键词：
14 year old 4 year old Adult Affect African American Age Behavioral Mechanisms Biological Biological Markers Body Composition Body fat Body mass index Buffers COVID-19 COVID-19 pandemic COVID-19 pandemic effects Cardiovascular system Cell Aging Child Child Care Child Health Child Rearing Childhood Chronic Clinical Communities Data Data Collection Development Economics Energy Intake Enrollment Ethnic Origin Exhibits Goals Health Health behavior Heel Hospitalization Household Hydrocortisone Inadequate Sleep Hygiene Income Inflammation Inflammatory Intervention Job loss Latino Longitudinal cohort Low income Measures Mediating Mental Health Metabolic Neighborhoods Neurosecretory Systems Obesity Outcome Overweight Oxidative Stress Parents Pathway interactions Physical activity Policies Population Prevalence Race Recording of previous events Reducing diet Research Resources Risk Security Self Efficacy Social Network Social isolation Stress Surveys Time Weight maintenance regimen Youth biobehavior cardiometabolic risk cardiometabolism cohort effective intervention ethnic diversity executive function experience food insecurity future outbreak housing instability imprint obesity in children obesity risk obesity treatment pandemic disease pandemic impact population health prevent prospective protective factors psychosocial stressors public health priorities racial diversity resilience response risk mitigation school disruption stressor trend tv watching

项目摘要

Project Summary/Abstract The COVID-19 pandemic has had an alarming impact on already unacceptably high childhood obesity rates, and emerging evidence shows that traditional approaches to pediatric weight management have been markedly less effective since the onset of the pandemic. As obesity during childhood is much more likely to be sustained during adulthood, and children with obesity and other chronic conditions are more likely to have severe forms of COVID-19 requiring hospitalization, this alarming increase in childhood obesity rates is poised to have a broad and long-term impact on population health unless effective interventions are implemented. Yet, we know very little about the unique drivers of this dramatic increase in childhood obesity and whether BMI increases will persist and become lifelong. We know even less about the protective factors that mitigate this risk, as some youth will not develop obesity/worsening cardiometabolic health or may recover quickly despite risk exposures. Our goals are to uncover the biobehavioral pathways through which pandemic-related stressors drive childhood obesity and cardiometabolic risk, and to identify protective factors and intervention targets to mitigate the long-term impact of the pandemic on children’s health. The proposed research offers a unique, time-sensitive opportunity to prospectively examine the impact of multilevel stressors brought on by the pandemic to identify factors influencing BMI and cardiometabolic health trajectories. We will leverage an established longitudinal cohort of racially/ethnically diverse children (60% Latino) from predominantly low- income households, who were enrolled at 2-4 years of age (U01HD068890) and followed annually through ages 7-11 (R01HD090059). Underscoring the timeliness, uniqueness, and significance of this cohort, body composition, cardiovascular and metabolic functioning, neuroendocrine, oxidative stress, and inflammatory biomarkers, and health behaviors were obtained just prior to the onset of the pandemic (n=338). Drawing on a rich history of longitudinal data over 5 previous timepoints including immediately prior to the pandemic, we propose to add two new waves of data collection (7- and 8-years after inception of the cohort, 2-3 years post- onset of the pandemic) when children will be 10-14 years of age, an important developmental window of obesity and cardiometabolic imprinting. Multiple levels of pandemic-related stressors will be measured, alongside gold standard biological measures of stress activation, adiposity and cardiometabolic health, objective health behavior measures, and parent-child surveys. Our specific aims focus on identifying the pathways, parent-child factors, and neighborhood/community contexts needed to guide effective childhood obesity interventions in the aftermath of the pandemic and reduce adverse health consequences among vulnerable and understudied populations.

项目概要/摘要 COVID-19 大流行对本已高得令人无法接受的儿童肥胖率产生了令人震惊的影响，新出现的证据表明，儿科体重管理的传统方法已经自大流行爆发以来，这种方法的效果明显较差，因为儿童时期肥胖的可能性更大。成年后持续存在，患有肥胖症和其他慢性病的儿童更有可能患有严重的 COVID-19 需要住院治疗，儿童肥胖率的惊人增长势在必行除非实施有效的干预措施，否则会对人口健康产生广泛和长期的影响。我们对儿童肥胖急剧增加的独特驱动因素知之甚少，也不知道体重指数是否我们对缓解这种情况的保护因素知之甚少。风险，因为一些青少年不会出现肥胖/心脏代谢健康状况恶化，或者可能会很快恢复我们的目标是揭示与流行病相关的生物行为途径。压力源会导致儿童肥胖和心脏代谢风险，并确定保护因素和干预措施拟议的研究提供了减轻大流行对儿童健康的长期影响的目标。独特的、时间敏感的机会前瞻性地检查由我们将利用流行病来确定影响体重指数和心脏代谢健康轨迹的因素。建立了种族/族裔多样化儿童（60％拉丁裔）的纵向队列，这些儿童主要来自低收入群体收入家庭，在 2-4 岁时入学 (U01HD068890)，并每年跟踪 7-11 岁 (R01HD090059) 强调该群体的及时性、独特性和重要性。成分、心血管和代谢功能、神经内分泌、氧化应激和炎症生物标志物和健康行为是在大流行爆发之前获得的（n = 338）。我们拥有过去 5 个时间点（包括大流行之前）的丰富纵向数据历史记录建议添加两波新的数据收集（队列开始后 7 年和 8 年，队列启动后 2-3 年）疫情爆发时）儿童年龄为 10 至 14 岁，这是儿童成长的重要时期将测量与大流行相关的压力源的多个水平，除了应激激活、肥胖和心脏代谢健康的黄金标准生物测量之外，客观的健康行为测量和亲子调查是我们的具体目标。指导有效童年所需的路径、亲子因素和邻里/社区背景大流行后的肥胖干预措施并减少对健康的不利影响弱势群体和未被充分研究的群体。