Emory Clinical Oncology Career Development Award K12 Program

埃默里临床肿瘤学职业发展奖 K12 计划

• 批准号: 10680377
• 负责人: Kavita Madhav Dhodapkar
• 金额: $ 55.37万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-02 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10680377
• 关键词: Address; Area; Clinical; Clinical Oncology; Clinical Research; Development; Diverse Workforce; Evaluation; Faculty; Funding; Future; Goals; Growth; Infrastructure; International; K-Series Research Career Programs; Knowledge; Lead; Malignant Neoplasms; Master of Science; Measures; Mentored Clinical Scientist Development Program; Mentors; Mentorship; Methods; Modification; Phase I Clinical Trials; Phase II Clinical Trials; Program Evaluation; Records; Research; Research Methodology; Research Personnel; Research Training; Therapeutic; Training; Training Programs; Translational Research; Underrepresented Minority; Universities; Woman; anticancer research; career development; design; early phase clinical trial; experience; instructor; member; next generation; professor; programs; recruit; research study; skills; tool

Project Summary/Abstract To address the need for a well-trained, diverse workforce of cancer investigators, we will establish a K12- funded oncology clinical research training and mentorship program for junior faculty researchers at Emory University's Winship Cancer Institute. The goals of the Emory Clinical Oncology Career Development Award Program are to: (1) establish an exceptional training program for clinician-investigators in the conduct of therapeutic cancer clinical research studies with a focus on phase 1 and phase 2 clinical trials, and (2) develop the next generation of researchers and leaders in clinical oncology. In year 1, we will develop the program recruitment materials; convene the program Internal and External Advisory Boards including faculty with expertise in clinical/translational research, clinical research methodology, and mentorship; finalize the intensive training, longitudinal training, career development, and mentored research experience program components; select the inaugural Emory Clinical Oncology Career Development Award Scholars; and implement the online program evaluation and Scholar evaluation tools. Two clinician-investigator junior faculty members (Instructor or Assistant Professor) will be selected each year and Scholars will complete a 2-year training program. To develop the knowledge and skills necessary to become independent cancer clinician-investigators and lead cancer research teams in the future, in years 2-5 Emory Clinical Oncology K12 Scholars will pursue: intensive didactic training focused on clinical research methodology for design and execution of early phase clinical trials; longitudinal didactic coursework leading to a Master of Science in Clinical Research (MSCR) degree; mentored research experiences, and professional development activities. The Emory Clinical Oncology K12 program will leverage the strengths and infrastructure of the Georgia Clinical & Translational Science Alliance at Emory. A comprehensive, rigorous mixed-methods evaluation plan will be used to assess program milestones and metrics, identify areas for modifications and growth, and measure the long-term impact of the Emory Clinical Oncology K12 program. Recruitment of women and under-represented minority candidates will be an important focus of this K12. The two PIs are internationally recognized cancer researchers with exceptional track records as mentors.

项目概要/摘要 为了满足对训练有素、多元化的癌症研究人员队伍的需求，我们将建立一个 K12- 资助埃默里大学初级研究人员的肿瘤学临床研究培训和指导计划 大学温希普癌症研究所。埃默里临床肿瘤职业发展奖的目标 计划旨在： (1) 为临床医生-研究者建立特殊的培训计划，以进行 治疗性癌症临床研究，重点是 1 期和 2 期临床试验，以及 (2) 开发 临床肿瘤学的下一代研究人员和领导者。在第一年，我们将开发该计划 招聘材料；召集该计划的内部和外部顾问委员会，包括教职员工 临床/转化研究、临床研究方法和指导方面的专业知识；最终确定强化 培训、纵向培训、职业发展和指导研究经验计划组成部分； 选出首届埃默里临床肿瘤学职业发展奖学者；并在网上实施 项目评估和学者评估工具。两名临床医生研究员初级教员（讲师 每年都会选拔学者或助理教授），学者将完成为期 2 年的培训计划。到 发展成为独立的癌症临床研究人员和领导者所需的知识和技能 埃默里临床肿瘤学 K12 学者未来 2-5 年的癌症研究团队将追求： 强化 教学培训侧重于早期临床设计和执行的临床研究方法 试验；获得临床研究理学硕士学位（MSCR）的纵向教学课程； 指导研究经验和专业发展活动。埃默里临床肿瘤学 K12 该计划将利用乔治亚州临床与转化科学联盟的优势和基础设施 在埃默里大学。将使用全面、严格的混合方法评估计划来评估项目 里程碑和指标，确定需要修改和增长的领域，并衡量长期影响 埃默里临床肿瘤学 K12 项目。招募女性和代表性不足的少数族裔候选人将 成为本次K12的一个重要焦点。这两位 PI 都是国际公认的癌症研究人员 作为导师的杰出记录。

项目成果

A systematic review of diagnostic, prognostic, and risk blood and urine biomarkers of transplant-associated thrombotic microangiopathy.

对移植相关血栓性微血管病的诊断、预后和风险血液和尿液生物标志物的系统评价。

• 发表时间: 2022
• 作者: Schoettler, Michelle L;Bhatt, Harshil;Vasu, Sumithira
• 通讯作者: Vasu, Sumithira

D-dimer and sinusoidal obstructive syndrome-novel poor prognostic features of thrombotic microangiopathy in children after hematopoietic cellular therapy in a single institution prospective cohort study.

D-二聚体和正窦阻塞综合征——单机构前瞻性队列研究中造血细胞治疗后儿童血栓性微血管病的新的不良预后特征。

• 发表时间: 2024-03
• 影响因子: 12.8
• 作者: Schoettler, Michelle L;French, Kaley;Harris, Anora;Bryson, Elyse;Deeb, Laura;Hudson, Zuri;Obordo, Jeremy;Chandrakasan, Shanmuganathan;Parikh, Suhag;Watkins, Benjamin;Stenger, Elizabeth;Qayed, Muna;Chonat, Satheesh;Westbrook, Adrianna;Switche
• 通讯作者: Switche

External Beam Radiation Therapy With or Without Brachytherapy Boost in Men With Very-High-Risk Prostate Cancer: A Large Multicenter International Consortium Analysis.

外束放射治疗联合或不联合近距离放射治疗对患有极高风险前列腺癌的男性有效果：一项大型多中心国际联盟分析。

• 发表时间: 2023-03-01
• 作者: Patel, Sagar A;Ma, Ting Martin;Wong, Jessica K;Stish, Bradley J;Dess, Robert T;Pilar, Avinash;Reddy, Chandana;Wedde, Trude B;Lilleby, Wolfgang A;Fiano, Ryan;Merrick, Gregory S;Stock, Richard G;Demanes, D Jeffrey;Moran, Brian J;Tran, Phuoc T
• 通讯作者: Tran, Phuoc T

Association of Brachytherapy Boost with Overall Survival for Gleason 9-10 Prostate Cancer: The Impact of Primary versus Secondary Pattern 5.

近距离放射治疗增强与格里森 9-10 前列腺癌总体生存率的关联：主要模式与次要模式的影响 5。

• 发表时间: 2023
• 影响因子: 1.9
• 作者: Patel, Sagar A;Baumann, Brian;Michalski, Jeff;Brenneman, Randall;Zheng, Bill;Gay, Hiram;Ferraro, Daniel;Brown, Simon A;Chang, Albert J;Rossi, Peter J;Fischer
• 通讯作者: Fischer