Functional Spectroscopy with Real-Time Feedback for Altering Preferences in Addic

具有实时反馈的功能光谱学可改变成瘾者的偏好

• 批准号: 8292242
• 负责人: HANS C BREITER
• 金额: $ 64.35万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8292242
• 关键词: Amygdaloid structure; Behavior; Behavior Therapy; Behavioral; Brain; Brain region; Cocaine; Computer software; Cues; Data; Data Display; Decision Making; Development; Drug Addiction; Drug usage; Effectiveness; Entropy; Evaluation; Exhibits; Experimental Psychology; Feedback; Fingers; Functional Imaging; Functional Magnetic Resonance Imaging; Future; Head; Hippocampus (Brain); Image; Impulsivity; Individual; Judgment; Laws; Learning; Link; Measurement; Measures; Methods; Metric; Monitor; Motion; Neurosciences; Nucleus Accumbens; Pattern; Performance; Pharmaceutical Preparations; Phase; Phenotype; Positioning Attribute; Predisposition; Prefrontal Cortex; Procedures; Recruitment Activity; Relative (related person); Rest; Rewards; Signal Transduction; Spectrum Analysis; Stimulus; Structure; Symptoms; System; Task Performances; Techniques; Technology; Testing; Therapeutic; Therapy Clinical Trials; Time; Training; Ventral Tegmental Area; Work; abstracting; addiction; base; brain behavior; design; drug addiction therapy; drug seeking behavior; healthy volunteer; interest; neuroimaging; preference; psychosocial; relating to nervous system; research study; response; software development; time use; tool; volunteer; Amygdaloid structure; Behavior; Behavior Therapy; Behavioral; Brain; Brain region; Cocaine; Computer software; Cues; Data; Data Display; Decision Making; Development; Drug Addiction; Drug usage; Effectiveness; Entropy; Evaluation; Exhibits; Experimental Psychology; Feedback; Fingers; Functional Imaging; Functional Magnetic Resonance Imaging; Future; Head; Hippocampus (Brain); Image; Impulsivity; Individual; Judgment; Laws; Learning; Link; Measurement; Measures; Methods; Metric; Monitor; Motion; Neurosciences; Nucleus Accumbens; Pattern; Performance; Pharmaceutical Preparations; Phase; Phenotype; Positioning Attribute; Predisposition; Prefrontal Cortex; Procedures; Recruitment Activity; Relative (related person); Rest; Rewards; Signal Transduction; Spectrum Analysis; Stimulus; Structure; Symptoms; System; Task Performances; Techniques; Technology; Testing; Therapeutic; Therapy Clinical Trials; Time; Training; Ventral Tegmental Area; Work; abstracting; addiction; base; brain behavior; design; drug addiction therapy; drug seeking behavior; healthy volunteer; interest; neuroimaging; preference; psychosocial; relating to nervous system; research study; response; software development; time use; tool; volunteer

Abstract This project will develop a real-time neuroimaging and behavioral method by which individuals with addiction may use brain- and keypress-based feedback to modulate their responses to drug cues, and alter brain and behavior signatures of addiction. Drug addiction can be characterized by a restructuring of the reward system to short-term rapid rewards, decreased assessment of long-term consequences, impulsivity, and a narrowing of the behavioral repertoire (i.e., restriction in the set of things toward which one shows preference). To deal with these symptoms of addiction, one therapeutic approach has been to develop urge minimization techniques through adaptations of behavioral therapy. These therapy techniques have traditionally focused on psychosocial measures of addiction that can be difficult to quantify or alter objectively. Recent advances in addiction neuroscience have revealed robust alterations of reward/aversion circuitry along with experimental psychology variables in addiction that may be amenable to use with behavioral techniques. Specifically, structural and functional MRI measures of prefrontal cortex, point to localized differences in addicts that can be connected with a keypress-based phenotype of relative preference that quantifies their restricted behavioral repertoire. Technical and computational advances suggest that these neuroscience measures might be harnessed for behavioral therapy. Toward this end, this project lays out a set of milestones as an R21 proposal to develop (a) a technical work-flow for high SNR, quantitative BOLD activation measurement based on single and double voxel spectroscopy; (b) real-time signal analysis and display software for feedback to individuals based on behavior and BOLD signal; (c) integration of platforms for imaging, experimental psychology, and feedback with subjects in the scanner. Following successful attainment of these milestones, a further set of milestones are organized as an R33 proposal to demonstrate: (d) that these technologies can be applied to monitor modulation of brain signal and relative preference phenotype by subjects, (e) integration of modulation of brain signal and keypress responses during realistic testing conditions, and (f) the application of these techniques to cocaine dependent subjects. We foresee these proof-of-concept milestones to be prerequisites for the future use of such a method in therapeutic trials.

抽象的 该项目将开发一种实时神经影像和行为方法 成瘾的人可能会使用基于脑和按键的反馈来调节其 对药物提示的反应，改变成瘾的大脑和行为特征。吸毒可以 以奖励系统重组为短期快速奖励的特征，减少 评估长期后果，冲动和行为曲目的狭窄 （即，限制一个显示出偏好的事物集）。处理这些 成瘾的症状，一种治疗方法是发展急促最小化 通过适应行为疗法的技术。这些疗法技术具有 传统上专注于成瘾的社会心理措施，可能很难量化或改变 客观地。成瘾神经科学的最新进展揭示了对 奖励/厌恶电路以及成瘾中的实验心理学变量 可以与行为技术一起使用。具体而言，结构和功能性MRI度量 前额叶皮层的属于瘾君子的局部差异，可以与 基于按键的相对偏好表型量化其限制行为 曲目。技术和计算进步表明这些神经科学措施 可能会利用行为疗法。为此，该项目列出了一套 里程碑是R21的提议，以开发（a）高SNR的技术工作流程 基于单素和双素光谱的大胆激活测量； （b）实时 信号分析和显示软件，以根据行为和大胆向个人反馈给个人 信号; （c）将成像，实验心理学和反馈反馈的平台集成 扫描仪中的主题。成功达到这些里程碑后，进一步 里程碑是作为R33的提议组织的，以证明：（d）这些技术可以是 应用于受试者对大脑信号和相对偏好表型的调制，（e） 在现实测试期间，大脑信号和按键响应的调制集成 条件，以及（f）将这些技术应用于可卡因依赖受试者。我们预见 这些概念证明的里程碑是将来使用这种方法的先决条件 治疗试验。