NINDS Center Core for Brain Imaging

NINDS 脑成像核心中心

• 批准号: 8022873
• 负责人: Daniel Scott Marcus
• 金额: $ 68.4万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-20 至 2014-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8022873
• 关键词: NINDS; Center; Core; Brain; Imaging

DESCRIPTION (provided by applicant): This proposal is to continue the NINDS Center Core for Brain Imaging (NCCBI) at Washington University. During its five years of operation, the NCCBI has become an integral resource for the University's neuroscience community, and during this time, imaging research has continued to evolve. Neuroimaging studies have become more expansive in terms of the number of research subjects involved, the types of image acquisitions utilized in protocols, the diversity of non-imaging measures that are included, and the extent of image post-processing and analysis that is conducted. The goal of the Center in the next funding cycle is to support the evolving practices of the University's neuroimaging community. The Center will achieve the following specific aims: 1. We will facilitate high throughput, highly interdisciplinary neuroimaging research. A software and hardware infrastructure will be deployed that will unify the imaging facilities, informational resources, and analytic capabilities into an organized and secure research platform. Key components will include DICOM data exchange services, an XNAT-based imaging informatics system, and integrated automated analysis pipelines. This infrastructure will be backed with expert consultation services, comprehensive documentation, and an extensive training program. 2. We will facilitate the transition of emergent imaging and analysis methods into production-grade research assets. A set of imaging methods have been identified that have associated analysis methods that are at various stages in the development pipelines, including anatomic MRI; diffusion tensor imaging; positron emission tomography studies of flow, metabolism and radioligand binding; arterial spin labeling MRI; and quantitative blood oxygen level dependent (BOLD) MRI. Through an iterative process of optimizing, automating, and documenting, we will speed the transition of these methods into investigator-friendly applications. Together these aims encapsulate a sweeping approach to supporting the University's neuroscience community by enabling the current state of the art practices and by advancing the next generation of groundbreaking practices. The NCCBI will include Administration, Informatics, and Analysis cores to achieve these aims.

描述（由申请人提供）：该建议是继续华盛顿大学的Ninds中心核心（NCCBI）。在运营的五年中，NCCBI已成为大学神经科学界不可或缺的资源，在此期间，成像研究继续发展。在涉及的研究对象的数量，在协议中使用的图像采集的类型，包括的非成像措施的多样性以及进行的图像后处理和进行分析的程度，神经影像学研究变得更加广泛。该中心在下一个融资周期中的目标是支持大学神经影像社区的不断发展的做法。该中心将实现以下特定目标：1。我们将促进高通量，高度跨学科的神经影像学研究。将部署软件和硬件基础架构，将成像设施，信息资源和分析功能统一为有组织且安全的研究平台。关键组件将包括DICOM数据交换服务，基于XNAT的成像信息系统和集成的自动分析管道。该基础设施将获得专家咨询服务，综合文档和广泛的培训计划的支持。 2。我们将促进新兴成像和分析方法向生产级研究资产的过渡。已经确定了一组具有相关分析方法的成像方法，这些分析方法在开发管道中的各个阶段，包括解剖MRI。扩散张量成像；流动，代谢和放射性结合的正电子发射断层扫描研究；动脉自旋标记MRI；和定量血氧水平依赖性（粗体）MRI。通过优化，自动化和记录的迭代过程，我们将加快这些方法向研究人员友好的应用程序的过渡。这些目标共同包含了一种通过实现当前的艺术实践并促进下一代突破性实践来支持大学神经科学社区的广泛方法。 NCCBI将包括管理，信息学和分析核心，以实现这些目标。