NINDS Center Core at the University of Minnesota

明尼苏达大学 NINDS 中心核心

基本信息

批准号：
8588811
负责人：
TIMOTHY J EBNER
金额：
$ 70.06万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-03-15 至 2015-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8588811
关键词：
Alzheimer&apos s Disease Bacterial Artificial Chromosomes Basic Science Behavior Behavioral Center Core Grants Cognitive Collaborations Communities Dependovirus Disease Equipment Evaluation Evaluation Studies Family Fostering Functional disorder Funding Gene Expression Generations Goals Grant Health Health Care Costs Histology Human Image Imaging Device In Vitro Individual Investigation Lead Methods Microscopy Minnesota Mission Motor Mus National Institute of Neurological Disorders and Stroke Nervous System Physiology Nervous system structure Neuraxis Neurological status Neurosciences Neurosciences Research Pain Parkinson Disease Patients Performance Phenotype Preparation Process Productivity Proteins Protocols documentation Qualifying Recombinant adeno-associated virus (rAAV)Research Research Infrastructure Research Personnel Resources Services Spinocerebellar Ataxias Structure Techniques Tissues Training Transgenic Mice Transgenic Organisms Translational Research United States National Institutes of Health Universities Viral Vector design genetic manipulation in vivo innovation mouse model nervous system disorder new technology novel therapeutic intervention optical imaging programs tool transgene expression two-photon

项目摘要

This is a proposal for an NINDS Institutional Center Core grant to support neuroscience research at the University of Minnesota. The mission of the Center and its Cores is to enhance basic and translational research on the nervous system by providing state-of-the art, shared equipment facilities with technical and scientific support. The Center brings together a primary group of 11 NINDS-funded investigators using mouse models to study human neurological disease/disorders and nervous system function. The Center also gives high priority to helping new neuroscience investigators establish their research programs and NINDS-funded investigators without qualifying grants. The Center also offers its services and resources when possible to a large group of investigators, many NIH funded, whose research is focused on the nervous system. The three research Cores provide technological services, training and scientific expertise to increase productivity, promote new research directions and foster collaborations among Center investigators. The Cores were selected to provide access to widely needed, even critical, tools used in the study of mouse models. These tools are best offered in a central facility in which investigators can take advantage of standardized and optimized protocols as well as expert technical assistance. The Cores were also selected to provide access to new, powerful tools for the investigation of nervous system function/dysfunction not generally available to individual investigators. By focusing on the study and evaluation of mouse models, there is a high potential for innovative synergistic effects across the Cores. The Genetic Manipulation Core provides the generation of bacterial artificial chromosome transgenic mice and viral vectors to manipulate gene expression in vitro and in vivo. The Behavioral Phenotyping Core provides facilities and technical support for the evaluation of a spectrum of motor and cognitive behaviors as well as general neurological status in the mouse. The Imaging and Tract Tracing Core provides investigators with the tools and expertise for modern imaging (single and two-photon microscopy), tract tracing/histology, and activity-dependent optical imaging. The fourth Administrative Core with the Executive Committee is responsible for Center oversight, administers the institutional sharing plan, promotes collaborations, informs the neuroscience community, seeks new technologies and evaluates the performance of the Center. The Center and Cores will increase the impact and productivity of NINDS-funded investigators, promote new research directions and foster collaborations among Center researchers.

这是Ninds机构中心核心拨款的一项建议，以支持明尼苏达大学的神经科学研究。该中心及其核心的任务是通过提供技术和科学支持的最先进，共享设备设施来增强神经系统的基础和转化研究。该中心使用小鼠模型汇集了一组由11名NINDS资助的研究者组成的，以研究人类神经系统疾病/疾病和神经系统功能。该中心还优先考虑新的神经科学调查人员建立他们的研究计划，并在没有合格赠款的情况下由NINDS资助的研究人员建立。该中心在可能的情况下还向一大批研究人员提供服务和资源，许多NIH资助了他们的研究，他们的研究专注于神经系统。这三个研究核心提供了技术服务，培训和科学专业知识，以提高生产力，促进中心研究人员之间的新研究方向并促进合作。选择了核心以提供对鼠标模型研究中使用的广泛所需（甚至关键的工具）的访问。这些工具最好在中央设施中提供，其中调查人员可以利用标准化和优化的协议以及专家技术援助。还选择了核心，以提供新的，有力的工具，以调查神经系统功能/功能障碍，通常不适用于个别研究人员。通过关注小鼠模型的研究和评估，在整个核心上具有很高的创新协同作用的潜力。遗传操纵核心提供了细菌人造染色体转基因小鼠和病毒载体的产生，以在体外和体内操纵基因表达。行为表型核心为评估运动和认知行为以及小鼠中的一般神经系统的评估提供了设施和技术支持。成像和道追踪核心为研究人员提供了现代成像（单个和两光子显微镜），道跟踪/组织学以及活动依赖性光学成像的工具和专业知识。执行委员会的第四个行政核心负责中心监督，管理机构共享计划，促进合作，告知神经科学社区，寻求新技术并评估中心的绩效。该中心和核心将提高NINDS资助的研究人员的影响和生产力，促进中心研究人员之间的新研究指导和促进合作。