NEI UCI Center Core Grant for Vision Research

NEI UCI 中心视觉研究核心资助

基本信息

批准号：
10676893
负责人：
Vladimir Jivkov Kefalov
金额：
$ 62.43万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-01 至 2027-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10676893
关键词：
Acceleration Area California Cell Culture Techniques Center Core Grants Collaborations Communities Core Facility Data Educational process of instructing Ensure Equipment Faculty Recruitment Funding Future Health Services Accessibility Human Resources Image Individual Infrastructure Institution Laboratories Maintenance Mass Spectrum Analysis Methods Microanatomy Ophthalmology Postdoctoral Fellow Productivity Proteomics Research Research Methodology Research Personnel Research Project Grants Research Support Research Technics Resources Sampling Scientist Services Stains Structure Students Technical Expertise Techniques Testing Time Training Universities Use of New Techniques Vision Vision research Voting Work career catalyst cost effectiveness empowerment improved instrument instrumentation lipidomics medical schools mid-career faculty new technology ocular imaging prevent programs recruit research facility research faculty tool

项目摘要

ABSTRACT This P30 application seeks support for the Cores of Vision Research within the University of California Irvine (UCI) that will strengthen and enhance NEI R01-funded research. The project also aims to support the major expansion of vision research currently under way at UCI. It will broaden and optimize research capabilities, support and expand existing research projects, and help establish new studies, ultimately boosting productivity and strengthening vision research at UCI. Three research Core modules have been identified that would provide substantial benefit to current and future NEI R01-funded projects at UCI: (i). Ocular Microanatomy; (ii) Visual Function and Non-invasive Ocular Imaging; and (iii) Ocular Mass Spectrometry, Lipidomics, and Proteomics. In addition, an Administrative Group will be established to facilitate and support the function of these research Cores. The three research Cores were selected by majority votes of all current NEI R01-funded investigators, and other investigators who are directly or indirectly involved in ophthalmic research at UCI. The most requested services were developed into the Cores described in this P30 application. The vision research community at UCI has grown significantly over the past several years with the recruitment of 4 senior and 2 junior investigators and the formation of the Center for Translational Vision Research (CTVR), with at least two more mid-career faculty recruitments in the works. This expansion has been made possible by the exceptional institutional support from the Department of Ophthalmology and the School of Medicine, who have committed significant financial and infrastructure resources to bolster the vision research community at UCI. The services provided by the Cores for Vision Research will meet the scientific needs of the NEI R01-funded researchers as well as of early-stage investigators, and will increase efficiency, accelerate progress, and encourage new research directions and scientific collaborations at UCI. The Cores will also provide training and access to state-of-the-art experimental tools for students and postdoctoral scholars and will help prepare them for successful careers in ocular research.

抽象的此 P30 应用程序寻求对加州大学视觉研究核心的支持尔湾 (UCI) 将加强和加强 NEI R01 资助的研究。该项目还旨在支持 UCI 目前正在进行视觉研究的重大扩展。它将扩大和优化研究能力，支持和扩展现有的研究项目，并帮助建立新的研究，最终提高 UCI 的生产力并加强视觉研究。三个研究核心模块已确定将为 UCI 当前和未来 NEI R01 资助的项目带来实质性好处：(i)。眼部显微解剖学； (ii) 视觉功能和非侵入性眼部成像； (iii) 眼部肿块光谱测定法、脂质组学和蛋白质组学。此外，还将设立一个行政小组，负责促进和支持这些研究核心的功能。三个研究核心由所有当前由 NEI R01 资助的调查员以及直接或间接资助的其他调查员的多数票间接参与 UCI 的眼科研究。最需要的服务被开发成此 P30 应用中描述的内核。 UCI 的视觉研究社区在过去几年中得到了显着发展过去几年招募了 4 名高级调查员和 2 名初级调查员并成立了研究中心转化视觉研究（CTVR），至少还有两名处于职业生涯中期的教师招聘正在进行中。这一扩展是由于教育部的特殊机构支持而得以实现的。眼科和医学院投入了大量资金和基础设施资源来支持 UCI 的视觉研究社区。视觉核心提供的服务研究将满足 NEI R01 资助的研究人员以及早期研究人员的科学需求研究人员，并将提高效率、加速进展并鼓励新的研究方向以及 UCI 的科学合作。核心还将提供培训和接触最先进的技术为学生和博士后学者提供实验工具，帮助他们为成功的职业生涯做好准备在眼科研究中。

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Germline knockout of Nr2e3 protects photoreceptors in three distinct mouse models of retinal degeneration.

Nr2e3 的种系敲除可保护三种不同的视网膜变性小鼠模型中的光感受器。

DOI：
发表时间：
2024-03-12
期刊：
影响因子：
11.1
作者：
Kolesnikov, Alexander V;Murphy, Daniel P;Corbo, Joseph C;Kefalov, Vladimir J
通讯作者：
Kefalov, Vladimir J

Mechanical Regulation of Retinal Vascular Inflammation and Degeneration in Diabetes.

糖尿病视网膜血管炎症和变性的机械调节。

DOI：
发表时间：
2024-02-01
期刊：
影响因子：
7.7
作者：
Chandrakumar, Sathishkumar;Santiago Tierno, Irene;Agarwal, Mahesh;Lessieur, Emma M;Du, Yunpeng;Tang, Jie;Kiser, Jianying;Yang, Xiao;Rodriguez, Anthony;Kern, Timothy S;Ghosh, Kaustabh
通讯作者：
Ghosh, Kaustabh

A novel quantification method for retinal pigment epithelium phagocytosis using a very-long-chain polyunsaturated fatty acids-based strategy.

使用基于超长链多不饱和脂肪酸的策略来定量视网膜色素上皮细胞吞噬作用的新方法。

DOI：
发表时间：
2023
期刊：
影响因子：
0
作者：
Gao, Fangyuan;Tom, Emily;Lieffrig, Stephanie A.;Finnemann, Silvia C.;Skowronska-Krawczyk, Dorota
通讯作者：
Skowronska-Krawczyk, Dorota

Saving eyesight, one gene at a time.

拯救视力，一次一个基因。