USC FaceBase III Craniofacial Development and Dysmorpholoy Data Management and Integration Hub

USC FaceBase III 颅面发育和畸形数据管理和集成中心

基本信息

批准号：
10674539
负责人：
Yang Chai
金额：
$ 254.06万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-01 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10674539
关键词：
Address Anatomy Animal Model Architecture Biology Biomedical Research Cells Collection Communication Communities Computers Craniofacial Abnormalities Data Data Set Development Dysmorphology Education and Outreach Educational Materials Ensure FAIR principles Face FaceBase Fostering Funding Future Genetic Goals Health Human Image Infrastructure Knowledge Lead Link Modeling Molecular National Institute of Dental and Craniofacial Research Outcome Phase Process Reproducibility Research Research Design Research Personnel Research Support Resources Retrieval Scientist Study models Training Training Activity Translating Visualization community engagement community setting craniofacial craniofacial development data curation data hub data integration data management data repository data resource data sharing data submission design empowerment experience experimental study heterogenous data high standard human data human model improved innovation large datasets next generation operation outreach quality assurance skills tool training opportunity usability user-friendly

项目摘要

PROJECT SUMMARY The major goal of the FaceBase Consortium is to advance research by creating comprehensive datasets of craniofacial development and dysmorphologies, and to disseminate these datasets to the wider craniofacial research community. The FaceBase 3 Data Management and Integration Hub builds on the existing and successful scientific and technical team that has lead the development, deployment, operation and community engagement of the FaceBase 2 data hub. Looking forward to the future impact of the FaceBase Consortium, we face major challenges that include: (1) how to annotate large datasets to empower the biomedical research community; (2) how to improve data integration and facilitate data search and retrieval from the hub; (3) how to use the data from FaceBase to design studies and otherwise inform our future research; and (4) how to translate our knowledge from animal model studies to improve human craniofacial health. Importantly, the projects we propose here are designed to address these issues as we develop anatomy-based comprehensive data search and display, incorporate additional datasets from the community, and promote the usage of FaceBase data. In pursuit of these goals, we propose the following three Specific Aims: Specific Aim 1: Create a FAIR data repository and resource hub for the craniofacial research community. Specific Aim 2: Promote and enable data contributions to FaceBase by NIDCR-supported researchers. Specific Aim 3: Foster a community of active FaceBase users through outreach activities and dissemination of new features and available datasets. We will create educational materials and provide training opportunities for the next generation of craniofacial researchers. Ultimately, our proposed projects will not only contribute to our comprehensive understanding of the molecular regulatory mechanisms of craniofacial development but will also demonstrate how others can use the datasets from the FaceBase Hub to develop innovative approaches to improve human health.

项目概要 FaceBase 联盟的主要目标是通过创建全面的数据集来推进研究颅面发育和畸形，并将这些数据集传播到更广泛的颅面研究社区。 FaceBase 3 数据管理和集成中心建立在现有和领导开发、部署、运营和社区的成功科技团队 FaceBase 2 数据中心的参与。展望FaceBase联盟未来的影响，我们面临的主要挑战包括：（1）如何注释大型数据集以增强生物医学研究的能力社区; （2）如何改进数据集成并方便从中心进行数据搜索和检索； (3)如何使用 FaceBase 的数据来设计研究并为我们未来的研究提供信息； (4)如何翻译我们从动物模型研究中获得的知识可改善人类颅面健康。重要的是，我们的项目这里提出的建议旨在在我们开发基于解剖学的综合数据搜索时解决这些问题并显示、合并来自社区的其他数据集，并促进 FaceBase 数据的使用。在为了追求这些目标，我们提出以下三个具体目标：具体目标 1：创建公平的数据颅面研究界的存储库和资源中心。具体目标 2：促进和启用数据 NIDCR 支持的研究人员对 FaceBase 的贡献。具体目标 3：培养活跃的社区 FaceBase 用户通过外展活动和传播新功能和可用数据集。我们将制作教育材料并为下一代颅面医学提供培训机会研究人员。最终，我们提出的项目不仅有助于我们全面了解颅面发育的分子调节机制，但也将展示其他人如何使用来自 FaceBase Hub 的数据集，用于开发改善人类健康的创新方法。