Peru Vanderbilt – PREvention through VacciNation Training (PREVENT) program

秘鲁范德比尔特 — 通过疫苗接种培训进行预防 (PREVENT) 计划

• 批准号: 10674393
• 负责人: CARLOS G GRIJALVA
• 金额: $ 25.14万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2027-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10674393
• 关键词: Academic Medical Centers; Address; Authorization documentation; Biological; Communicable Diseases; Data; Developing Countries; Development; Disease; Doctor of Philosophy; Ensure; Evaluation; Faculty; Fellowship; Future; Goals; Grant; Growth; Herd Immunity; Immunization Programs; Knowledge; Lead; Mentors; Modernization; Peru; Pharmacoepidemiology; Prevention; Process; Productivity; Program Evaluation; Research; Research Personnel; Scientist; Structure; Technical Expertise; Training; Training Programs; Vaccination; Vaccines; antimicrobial resistant infection; authority; distrust; implementation evaluation; low and middle-income countries; multidisciplinary; pressure; programs; success; tool; unvaccinated; vaccine development; vaccine trial; vaccinology

SUMMARY While vaccination is the most efficient tool for the prevention of infectious diseases both in developed and developing countries, the implementation of effective vaccination programs is challenging. The development, introduction and implementation of effective vaccination depends on availability of locally generated evidence, especially data required by local regulatory authorities. An essential requirement to make this happen is to have well-trained local researchers who have a clear understanding of the process behind vaccine development, vaccine introduction and program implementation. Training of researchers on the achieved impact of vaccination on antimicrobial resistant infections, the relevance of indirect protection and the biological pressure induced by vaccination programs are examples of well-established vaccination topics that are commonly overlooked. A proper understanding of the effects of vaccination on unvaccinated groups through indirect or herd immunity is crucial, but this is frequently misinterpreted. Moreover, there is a growing distrust in vaccines and vaccination programs that needs to be addressed by researchers with appropriate technical skills. Thus, there is a growing global need for training in vaccinology and the study of vaccine-preventable diseases encompassing the entire process from vaccine development to field implementation and program evaluation. To address these needs, Vanderbilt University Medical Center (VUMC), the Instituto de Investigacion Nutricional (IIN) and the Universidad Peruana Cayetano Heredia (UPCH) are joining forces to build the Peru-Vanderbilt Prevention through Vaccination Training Program (PREVENT). The overall goal of PREVENT is to develop a cadre of researchers and educators equipped with modern knowledge and expertise to lead vaccine preventable diseases research and training in Peru and to encourage US-based researchers to engage in vaccination research in low- and middle-income country (LMICs). PREVENT builds on the very successful 14-year Research Partnership with the IIN and UPCH and on the Vanderbilt Vaccine Training and Evaluation Unit and the Division of Pharmacoepidemiology's expertise in the study of vaccine preventable diseases, training and mentoring. PREVENT will support 10 medium-long term trainees (Master's, PhD and faculty fellowships). Specifically, PREVENT aims to 1) Train a cadre of researchers and educators (trainers) to conduct multidisciplinary vaccine preventable diseases research and build training capacity in Peru; 2) Train scientists and future leaders in vaccine-preventable diseases research in Peru; and, 3) Ensure and document PREVENT's long-term impact. The ongoing IIN/UPCH-Vanderbilt Research Partnership has proven highly productive and successful. A new training program focusing on Vaccinology and the study of vaccine preventable diseases and the growth of structures and efforts to increase grant success will move IIN and UPCH toward a new horizon in vaccine preventable diseases and address Peru's need for a world-class workforce trained in vaccinology.

概括 尽管在发达国家和地区，疫苗接种都是预防传染病的最有效工具。 在发展中国家，实施有效的疫苗接种计划具有挑战性。的发展， 有效疫苗接种的引入和实施取决于当地产生的证据的可用性， 特别是当地监管机构要求的数据。实现这一目标的一个基本要求是 拥有训练有素的当地研究人员，他们对疫苗背后的过程有清晰的了解 开发、疫苗引进和计划实施。对研究人员进行关于所取得成果的培训 疫苗接种对抗菌药物耐药性感染的影响、间接保护的相关性和生物效应 疫苗接种计划引起的压力是公认的疫苗接种主题的例子，这些主题 经常被忽视。通过以下方式正确了解疫苗接种对未接种疫苗群体的影响 间接免疫或群体免疫至关重要，但这经常被误解。不仅如此，人们的不信任感也日益增强 需要由具有适当技术的研究人员解决的疫苗和疫苗接种计划 技能。因此，全球对疫苗学培训和疫苗可预防性研究的需求日益增长 涵盖从疫苗研发到现场实施和规划的整个过程的疾病 评估。为了满足这些需求，范德比尔特大学医学中心 (VUMC)、Instituto de Investigacion Nutricional (IIN) 和 Universidad Peruana Cayetano Heredia (UPCH) 正在联手 建立秘鲁-范德比尔特通过疫苗接种预防培训计划（PREVENT）。总体目标为 PREVENT 是培养一支具备现代知识和专业知识的研究人员和教育工作者队伍 领导秘鲁的疫苗可预防疾病研究和培训，并鼓励美国研究人员 参与低收入和中等收入国家（LMIC）的疫苗接种研究。 PREVENT 建立在非常 与 IIN 和 UPCH 以及范德比尔特疫苗培训和研究中心成功建立了 14 年的研究合作伙伴关系 评估组和药物流行病学处在疫苗可预防研究方面的专业知识 疾病、培训和指导。 PREVENT将支持10名中长期培训生（硕士、博士和 教师奖学金）。具体而言，预防的目标是 1) 培训一支由研究人员和教育工作者（培训师）组成的骨干队伍， 在秘鲁开展多学科疫苗可预防疾病研究并建设培训能力； 2) 火车 秘鲁疫苗可预防疾病研究的科学家和未来领导者；以及，3) 确保并记录 防止长期影响。事实证明，正在进行的 IIN/UPCH-范德比尔特研究合作关系非常有效 富有成效且成功。专注于疫苗学和疫苗研究的新培训计划 可预防的疾病以及增加拨款成功的结构和努力的发展将推动 IIN 和 UPCH 迈向疫苗可预防疾病的新视野，并满足秘鲁对世界级疫苗的需求 接受过疫苗学培训的劳动力。