Cue-triggered reward seeking

提示触发奖励寻求

• 批准号: 8288230
• 负责人: Kent C. Berridge
• 金额: $ 33.38万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8288230
• 关键词: Abstinence; Agonist; Amygdaloid structure; Animal Model; Animals; Behavior; Behavioral; Binge Eating; Binge eating disorder; Brain; Cell Nucleus; Cocaine; Conditioned Stimulus; Contralateral; Cues; Desire for food; Dopamine; Drug Addiction; Drug Sensitization; Eating; Eating Disorders; Food; Functional disorder; Generations; Goals; Human; Hunger; Incentives; Individual; Laboratory Study; Learning; Light; Location; Maps; Measurable; Measures; Mediating; Memory; Methods; Microinjections; Motivation; Nucleus Accumbens; Opioid; Pharmaceutical Preparations; Property; Rattus; Relapse; Relative (related person); Rewards; Role; Smoker; Sodium; Sodium Chloride; Specificity; Stimulus; Structure; Sucrose; System; Techniques; Testing; Time; abstracting; addiction; base; classical conditioning; conditioning; craving; design; drinking; drug addict; drug reward; hedonic; insight; mesolimbic system; neglect; neurochemistry; neuromechanism; psychologic; relating to nervous system; research study; tool

Abstract Recovering drug addicts encounter danger when faced with drug-related cues or contexts, because those situations can trigger relapse. Similarly, bouts of binge eating are often triggered by cues for food relevant rewards. Cues are especially potent triggers when individuals are in vulnerable states. These proposal aims to identify the brain states that cause vulnerability to cue-triggered 'wanting' of reward. The responsible brain mechanisms particularly involve the limbic nucleus accumbens and amygdala. Here we will study how these brain mechanisms cause excessive incentive salience ('wanting') to be attributed to particular reward cues. In experiment 1, microinjections of agonist drugs and a Fos plume mapping tool will be used to identify the neural mechanisms in nucleus accumbens and amygdala that magnify cue-triggered 'wanting'. In experiment 2, the circuit principles that join together the nucleus accumbens and amygdala into a cooperative system will be identified by manipulating the structures with multiple simultaneous microinjections. In experiment 3, prior neural sensitization and learning manipulations will help show how natural 'wanting' mechanisms are usurped by drugs and sensitization to cause an addicted reward to be 'wanted' more than other rewards. These studies will help clarify the brain and psychological mechanisms that cause addicts to excessively 'want' drug and binge eaters to excessively 'want' food rewards.

抽象的 恢复吸毒者时，面对与毒品有关的提示或 上下文，因为这些情况会触发复发。同样，暴饮暴食 通常是由相关奖励的提示引发的。提示特别有力触发器 当个人处于脆弱状态时。这些建议旨在识别大脑 指出会导致脆弱性提示触发的“渴望”的奖励。负责 脑机制特别涉及伏隔核和杏仁核。 在这里，我们将研究这些大脑机制如何引起激励显着性 （“想要”）归因于特定的奖励提示。在实验1中，微注射 激动剂药物和FOS羽状映射工具将用于识别神经 伏隔核和杏仁核的机制，它们放大了提示触发的“想要”。 在实验2中，将伏隔核融合在一起的电路原理和 将通过操纵结构来识别杏仁核成合作系统 具有多个同时的微型注射。在实验3中，先前的神经敏化 学习操作将有助于展示“渴望”机制的自然 被毒品篡夺和敏感化，导致上瘾的奖励被“想要”的奖励多于 其他奖励。这些研究将有助于阐明大脑和心理机制 这会导致瘾君子过度“想要”毒品和暴饮暴食者过度“想要”食物 奖励。