Cue-triggered reward seeking

提示触发奖励寻求

• 批准号: 7867866
• 负责人: Kent C. Berridge
• 金额: $ 34.41万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7867866
• 关键词: Abstinence; Agonist; Amygdaloid structure; Animal Model; Animals; Behavior; Behavioral; Binge Eating; Binge eating disorder; Brain; Cell Nucleus; Cocaine; Conditioned Stimulus; Contralateral; Cues; Desire for food; Dopamine; Drug Addiction; Drug Sensitization; Eating; Eating Disorders; Food; Functional disorder; Generations; Goals; Human; Hunger; Incentives; Individual; Laboratory Study; Learning; Light; Location; Maps; Measurable; Measures; Mediating; Memory; Methods; Microinjections; Motivation; Nucleus Accumbens; Opioid; Pharmaceutical Preparations; Property; Rattus; Relapse; Relative (related person); Rewards; Role; Smoker; Sodium; Sodium Chloride; Specificity; Stimulus; Structure; Sucrose; System; Techniques; Testing; Time; addiction; base; classical conditioning; conditioning; craving; design; drinking; drug addict; drug reward; hedonic; insight; mesolimbic system; neglect; neurochemistry; neuromechanism; psychologic; public health relevance; relating to nervous system; research study; tool

DESCRIPTION (provided by applicant): Recovering drug addicts encounter danger when faced with drug-related cues or contexts, because those situations can trigger relapse. Similarly, bouts of binge eating are often triggered by cues for food relevant rewards. Cues are especially potent triggers when individuals are in vulnerable states. These proposal aims to identify the brain states that cause vulnerability to cue-triggered 'wanting' of reward. The responsible brain mechanisms particularly involve the limbic nucleus accumbens and amygdala. Here we will study how these brain mechanisms cause excessive incentive salience ('wanting') to be attributed to particular reward cues. In experiment 1, microinjections of agonist drugs and a Fos plume mapping tool will be used to identify the neural mechanisms in nucleus accumbens and amygdala that magnify cue-triggered 'wanting'. In experiment 2, the circuit principles that join together the nucleus accumbens and amygdala into a cooperative system will be identified by manipulating the structures with multiple simultaneous microinjections. In experiment 3, prior neural sensitization and learning manipulations will help show how natural 'wanting' mechanisms are usurped by drugs and sensitization to cause an addicted reward to be 'wanted' more than other rewards. These studies will help clarify the brain and psychological mechanisms that cause addicts to excessively 'want' drug and binge eaters to excessively 'want' food rewards. PUBLIC HEALTH RELEVANCE: A primary problem in drug addiction and binge eating disorders is the continuing danger for relapse posed by encounters with cues for the addicted reward (even after long periods of abstinence). A brain mechanism has been hypothesized to cause cue-triggered relapse, namely incentive sensitization of brain systems that generate normal 'wanting' for rewards. The studies proposed here will help reveal those brain mechanisms underlying cue-triggered relapse, and will shed light on how compulsive 'wants' are produced in addiction and in eating disorders.

描述（由申请人提供）：恢复吸毒者在面对与药物有关的提示或环境时会遇到危险，因为这些情况可能会触发复发。同样，狂饮饮食的回合通常是由相关奖励的提示引发的。当个人处于脆弱状态时，提示尤其是有效的触发因素。这些建议旨在确定大脑状态会导致脆弱性提示“渴望”的奖励。负责任的大脑机制特别涉及伏隔核和杏仁核。在这里，我们将研究这些大脑机制如何导致过度的激励显着性（“想要”）归因于特定的奖励提示。在实验1中，将使用激动剂药物和FOS羽状映射工具的显微注射来鉴定伏隔核和杏仁核中的神经机制，以放大提示提示触发的“想要”。在实验2中，将通过操纵多个同时微型注射的结构来识别将伏隔核和杏仁核结合在一起的电路原理。在实验3中，先前的神经敏化和学习操作将有助于展示毒品和敏化的自然“欲望”机制如何使上瘾的奖励比其他奖励更大。这些研究将有助于阐明导致上瘾者过度“想要”药物和暴饮暴食者过度“想要”食物回报的大脑和心理机制。公共卫生相关性：药物成瘾和暴饮暴食障碍的主要问题是因与上瘾的奖励提示所遇到的复发的持续危险（即使经过长时间的禁欲）。已经假设了一种大脑机制会导致提示触发的复发，即对大脑系统的激励敏化，从而产生正常的“想要”以获得奖励。这里提出的研究将有助于揭示提示触发的复发的基础的大脑机制，并将阐明如何在成瘾和饮食失调中产生强迫性的“需求”。