Cue-triggered reward seeking

提示触发奖励寻求

基本信息

批准号：
8094369
负责人：
Kent C. Berridge
金额：
$ 33.38万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-01 至 2014-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8094369
关键词：
Abstinence Agonist Amygdaloid structure Animal Model Animals Behavior Behavioral Binge Eating Binge eating disorder Brain Cell Nucleus Cocaine Conditioned Stimulus Contralateral Cues Desire for food Dopamine Drug Addiction Drug Sensitization Eating Eating Disorders Food Functional disorder Generations Goals Health Human Hunger Incentives Individual Laboratory Study Learning Light Location Maps Measurable Measures Mediating Memory Methods Microinjections Motivation Nucleus Accumbens Opioid Pharmaceutical Preparations Property Rattus Relapse Relative (related person)Rewards Role Smoker Sodium Sodium Chloride Specificity Stimulus Structure Sucrose System Techniques Testing Time addiction base classical conditioning conditioning craving design drinking drug addict drug reward hedonic insight mesolimbic system neglect neurochemistry neuromechanism psychologic relating to nervous system research study tool

项目摘要

DESCRIPTION (provided by applicant): Recovering drug addicts encounter danger when faced with drug-related cues or contexts, because those situations can trigger relapse. Similarly, bouts of binge eating are often triggered by cues for food relevant rewards. Cues are especially potent triggers when individuals are in vulnerable states. These proposal aims to identify the brain states that cause vulnerability to cue-triggered 'wanting' of reward. The responsible brain mechanisms particularly involve the limbic nucleus accumbens and amygdala. Here we will study how these brain mechanisms cause excessive incentive salience ('wanting') to be attributed to particular reward cues. In experiment 1, microinjections of agonist drugs and a Fos plume mapping tool will be used to identify the neural mechanisms in nucleus accumbens and amygdala that magnify cue-triggered 'wanting'. In experiment 2, the circuit principles that join together the nucleus accumbens and amygdala into a cooperative system will be identified by manipulating the structures with multiple simultaneous microinjections. In experiment 3, prior neural sensitization and learning manipulations will help show how natural 'wanting' mechanisms are usurped by drugs and sensitization to cause an addicted reward to be 'wanted' more than other rewards. These studies will help clarify the brain and psychological mechanisms that cause addicts to excessively 'want' drug and binge eaters to excessively 'want' food rewards. PUBLIC HEALTH RELEVANCE: A primary problem in drug addiction and binge eating disorders is the continuing danger for relapse posed by encounters with cues for the addicted reward (even after long periods of abstinence). A brain mechanism has been hypothesized to cause cue-triggered relapse, namely incentive sensitization of brain systems that generate normal 'wanting' for rewards. The studies proposed here will help reveal those brain mechanisms underlying cue-triggered relapse, and will shed light on how compulsive 'wants' are produced in addiction and in eating disorders.

描述（由申请人提供）：戒毒者在面对与毒品相关的线索或情境时会遇到危险，因为这些情况可能会引发旧病复发。同样，暴饮暴食的发作通常是由与食物相关的奖励暗示引发的。当个人处于脆弱状态时，暗示是特别有效的触发因素。这些提议旨在识别导致对提示触发的“想要”奖励的脆弱性的大脑状态。负责的大脑机制特别涉及伏隔边缘核和杏仁核。在这里，我们将研究这些大脑机制如何导致过度的激励显着性（“想要”）归因于特定的奖励线索。在实验 1 中，显微注射激动剂药物和 Fos 羽流绘图工具将用于识别伏隔核和杏仁核中放大提示触发的“需求”的神经机制。在实验 2 中，将通过同时进行多个显微注射来操纵这些结构，从而确定将伏隔核和杏仁核连接成协作系统的电路原理。在实验 3 中，先前的神经敏化和学习操作将有助于展示自然的“想要”机制如何被药物和敏化所篡夺，从而导致上瘾的奖励比其他奖励更“想要”。这些研究将有助于阐明导致成瘾者过度“想要”药物和暴食者过度“想要”食物奖励的大脑和心理机制。公共卫生相关性：吸毒成瘾和暴食症的一个主要问题是，遇到成瘾奖励的线索（即使在长期禁欲之后）会造成持续的复发危险。假设大脑机制会导致提示触发的复发，即大脑系统的激励敏感化，产生对奖励的正常“渴望”。这里提出的研究将有助于揭示线索触发复发的大脑机制，并将揭示成瘾和饮食失调中强迫性“欲望”是如何产生的。