Emory Alzheimer's Disease Research Center

埃默里阿尔茨海默病研究中心

基本信息

批准号：
10673933
负责人：
ALLAN I LEVEY
金额：
$ 288.47万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-15 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10673933
关键词：
Academic Medical Centers Acceleration Action Research Address Advocate Affect African American African American population Alzheimer disease prevention Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Area Autopsy Awareness Biological Markers Biological Specimen Banks Blood Brain Brain imaging Caring Clinic Clinical Clinical Research Clinical Trials Clinical Trials Support Unit Collaborations Communities Complement DNA Data Data Scientist Dedications Dementia Development Disease Disparity Early identification Education Faculty Family Caregiver Fostering Foundations Funding Genetic Goals Grant Health Professional Heterogeneity Image Individual Individual Differences Institution Intervention Leadership Link Memory Outcome Participant Pathogenicity Personal Satisfaction Pilot Projects Plasma Play Prevention Proteins Proteomics Public Health Publications Race Recommendation Research Research Activity Research Personnel Research Support Resources Risk Risk Factors Role Sampling Scientist Special Population Specimen Spinal Cord Teacher Professional Development Training Translating Translational Research Translations Underrepresented Minority United States National Institutes of Health Universities Variant Work base built environment burden of illness caregiving caregiving research clinical practice cohort community partnership data management design diversity and inclusion education research effective therapy empowerment ethnoracial faculty mentor healthy aging improved innovation memory care minority engagement multidisciplinary neuropathology next generation novel outreach programs recruit research study response success supportive environment symposium therapeutic target training opportunity

项目摘要

SUMMARY/ABSTRACT: OVERALL The Goizueta Alzheimer’s Disease Research Center (ADRC) at Emory University provides Georgia and the region with comprehensive clinical, research, and educational programs. This application outlines our success in building an environment that encourages and supports innovative projects with a central theme of discovery and translation of new biomarkers and pathogenic mechanisms to enable early identification, intervention, and ultimately prevention of AD and related disorders. Given the well documented disparities in clinical research participation and burden of disease for AD in the African American community, the Goizueta ADRC dedicates effort and resources to help better understand and address inter-individual differences in AD and ADRD, ranging from ethno-racial factors to individual differences in genetic and protein variation. We benefit from generous institutional support from Emory, one of the nation’s fastest growing research academic medical centers, the generous Atlanta community, and a large and highly collaborative interdisciplinary team of more than 100 faculty across Emory and local institutions. Our cores work in a concerted manner to effectively recruit, evaluate, and engage a diverse cohort of participants who actively take part in a wide variety of research studies. The addition of a Minority Engagement Core helps to further engage special populations, most notably the African American community, to help the Outreach, Recruitment and Engagement Core and Clinical Core with an ambitious goal of 50% African American participation in the UDS cohort. Our Biomarker Core provides state-of-the-art genetic, proteomic, and brain imaging analyses, complemented by an extensive biospecimen repository of well-characterized blood, CSF, and DNA samples, and a large bank of well- characterized postmortem brains and spinal cords in the Neuropathology Core. These valuable resources will continue to be distributed widely for a variety of approved studies, including research Developmental Projects and in support of local and national collaborations. Generous institutional and philanthropic support is used to seed a much larger base of innovative research. The ADRC educational programs reach a broad audience of trainees, researchers, health care professionals, and the public. New to us with this application, the Research Education Component will help formalize our longstanding dedication to the cultivation of the next generation of scientists. With a strong commitment to diversity and inclusiveness, our program benefits from the engagement of a large and multidisciplinary core of training faculty mentors from institutions throughout the greater Atlanta area. Collectively, the ADRC is poised to continue to make important contributions to the national strategy for AD treatment and prevention.

摘要/摘要：总体埃默里大学戈伊苏埃塔阿尔茨海默病研究中心 (ADRC) 为佐治亚州和该应用程序概述了我们的成功。建立一个鼓励和支持以发现为中心主题的创新项目的环境和翻译新的生物标志物和致病机制，以实现早期识别、干预和治疗鉴于临床研究中有充分记录的差异，最终预防 AD 和相关疾病。戈伊苏埃塔 ADRC 致力于非裔美国人社区 AD 的参与和疾病负担努力和资源帮助更好地理解和解决 AD 和 ADRD 的个体差异，从民族种族因素到遗传和蛋白质变异的个体差异，我们都受益匪浅。来自埃默里大学的慷慨机构支持，埃默里大学是美国发展最快的研究学术医学之一中心、慷慨的亚特兰大社区，以及一个由更多人组成的大型且高度协作的跨学科团队埃默里大学和当地机构的 100 多名核心教师齐心协力，高效工作。招募、评估和吸引积极参与各种活动的多元化参与者少数族裔参与核心的增加有助于进一步吸引特殊人群，最值得注意的是非裔美国人社区，以帮助外展、招聘和参与核心和临床核心的雄心勃勃的目标是 50% 的非裔美国人参与 UDS 队列。 Core 提供最先进的遗传、蛋白质组和脑成像分析，并辅以广泛的生物样本库，包含经过充分表征的血液、脑脊液和 DNA 样本，以及大量经过充分鉴定的样本这些宝贵的资源将在神经病理学核心中描述死后大脑和脊髓的特征。继续广泛分发用于各种批准的研究，包括研究开发项目并支持地方和国家合作。 ADRC 教育项目覆盖更广泛的受众。受训者、研究人员、医疗保健专业人员和公众对我们来说是新的应用程序，即研究。教育部分将有助于正式化我们对培养下一代的长期奉献凭借对多样性和包容性的坚定承诺，我们的计划受益于来自世界各地各机构的大型、多学科培训教师导师的核心参与总的来说，ADRC 准备继续为大亚特兰大地区做出重要贡献。 AD 治疗和预防国家战略。