Research Translation Core

研究翻译核心

基本信息

批准号：
7932382
负责人：
Joel D Schwartz
金额：
$ 17.26万
依托单位：
HARVARD SCHOOL OF PUBLIC HEALTH
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-04-12 至 2014-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7932382
关键词：
Arsenic Basic Science Biological Availability Biological Markers Boston Case Study Chemistry Collaborations Communication Community Outreach Data Decision Making Decision Theory Development Ecology Economics Educational workshop Ensure Environment Environmental Health Epidemiology Exposure to General Population Genes Genetic Predisposition to Disease Goals Interest Group Journals Lead Mails Manganese Metals Methodology Oxidation-Reduction Peer Review Policies Policy Developments Policy Maker Population Public Health Publications Publishing Relative (related person)Research Research Personnel Research Training Risk Risk Assessment Science Policy Series Site Superfund Technology Training Programs Translating Translational Research United States National Institutes of Health Universities Work Writing base college data modeling environmental toxicology gene environment interaction genetic epidemiology land use metal poisoning neurodevelopment novel outreach program policy implication programs remediation sensor special interest group symposium tool web site

项目摘要

The goal ofthe Research Translation Core is to actively communicate important research findings emanating from the program in the manner most appropriate for the intended audience, with the goal of ensuring the accurate and timely use of data. The Research Translation Core is organized through the Harvard Center for Risk Analysis (HCRA). HCRA, founded in 1989, has always enjoyed extensive collaboration with and support from regulatory agencies, corporations, interest groups, and colleagues at many universities in the US and abroad, and provides an existing base from which to interpret and disseminate research results to a variety of stakeholders and technical audiences. Much of the integration across specific projects and cores is accomplished through HCRA's demonstrated ability to synthesize and interpret research results in terms of relevance to risk-based environmental decision-making. We will evaluate and synthesize the results of the specific projects and cores in terms of the implications for risk assessment and subsequent decisionmaking and policy development using case studies and examples for dissemination through HCRA-led publications, conferences, seminars, workshops, and the SBRP and HCRA websites, as well as through community outreach programs. Potential neurodevelopmental risks as a result of exposure to mixtures of arsenic, manganese, and lead in the environment depend on the mobility and bioavailability of the constituents under different environmental conditions as well as potential genetic susceptibility of exposed populations. The Research Translation Core, through the use of case studies and focused integrative analyses, will demonstrate and communicate the public health implications of changes in bioavailability on exposure, genetic susceptibility relative to population risks, and potential biomarkers of exposure and effect to facilitate risk assessment.

研究翻译核心的目的是以最适合预期受众的方式积极地传达从计划中发出的重要研究结果，以确保准确，及时地使用数据。研究翻译核心是通过哈佛风险分析中心（HCRA）组织的。 HCRA成立于1989年，一直与美国和国外许多大学的监管机构，公司，利益集团和同事的广泛合作和支持，并提供了现有的基础，以向各种利益相关者和技术受众解释和传播研究结果。通过HCRA表现出的综合和解释研究结果的能力来实现特定项目和核心之间的大部分集成与基于风险的环境决策相关。我们将根据对风险评估以及随后的决策和政策制定的影响，评估和综合特定项目和核心的结果，并通过案例研究和示例通过HCRA领导的出版物，会议，研讨会，研讨会，SBRP和HCRP和HCRP网站以及通过社区揭幕计划，以及通过社区揭幕计划进行传播。由于暴露于砷，锰和环境中铅的混合物的结果，潜在的神经发育风险取决于成分在不同环境条件下的迁移率和生物利用度以及暴露群体的潜在遗传易感性。通过使用案例研究和集中综合分析，研究翻译核心将证明和传达生物利用度变化对暴露的公共卫生影响，相对于人口风险的遗传敏感性以及暴露量的潜在生物标志物以及影响促进风险评估的潜在生物标志物。