Superfund Metal Mixtures, Biomarkers and Neurodevelopment

Superfund 金属混合物、生物标志物和神经发育

基本信息

批准号：
8254509
负责人：
David C Bellinger
金额：
$ 243.6万
依托单位：
HARVARD SCHOOL OF PUBLIC HEALTH
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-04-12 至 2014-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8254509
关键词：
2 year old Address Advisory Committees Age Animals Arsenic Bangladesh Basic Science Bioinformatics Biological Biological Availability Biological Markers Biology Birth Boston Candidate Disease Gene Characteristics Child Child Development Childhood Cities Communication Complex Country DRD4 gene Data Developed Countries Developing Countries Development Dose Ensure Environment Environmental Health Figs - dietary Fostering Funding Future Gasoline Gene Expression Genes Genetic Genetic Predisposition to Disease Genotype Goals Grant Health Human Human Genome Income Infant Institution Institutional Review Boards Knowledge Lead Lead Poisoning Leadership Life Manganese Measures Metal exposure Metals Mexico Monitor Movement National Institute of Environmental Health Sciences Neurons Outcome Parents Pathway Analysis Phase Phenotype Population Prevention program Probability Public Health Schools Publishing RNA Interference Regulation Research Research Personnel Resource Sharing Resources Sample Size Site Structure Superfund System Tars Technology Testing Time Toxic effect Toxicogenomics Translating United States National Institutes of Health Universities Variant Water Work base blood lead cohort design dopamine transporter experience gene environment interaction genetic variant genome wide association study intervention program meetings metal poisoning named group neurodevelopment neurotoxic population based prenatal programs prospective superfund site tool

项目摘要

DESCRIPTION (provided by applicant): The Administrative Core promotes intellectual activities, organization of venues for planning future research through seminars and retreats, and oversight of research and spending. This Core also provides the tools to work with institutions inside and outside of Harvard School of Public Health to leverage the potential of the Superfund Basic Research Program to translate the findings of our research and to promote research on mixtures, gene-environment interactions, and the movement of metals in the environment. The specific aims of the Administrative Core are to: Aim 1- Research- To monitor research progress, coordinate Internal Advisory Committee (Governance Committee) meetings, and foster collaborative research both within the SBRP Program and among other Harvard affiliated institutions and collaborative institutions, such as MIT; Aim 2- Communication- To foster communication between the Harvard SBRP and SBRP programs within EPA Region 1 (Dartmouth, Brown, Boston University) and agencies such as EPA, ATSDR and the Pediatric Environmental Health Subspecialty Units (PEHSUs), and to maintain close communication with the National Institute of Environmental Health Sciences; Aim 3-To provide necessary resources and fiscal oversight; Aim 4- To promote rapid dissemination of significant research findings; and Aim 5- Compliance- To ensure compliance with NIH requirements for data and resource-sharing and the human and animal institutional review board requirements PUBLIC HEALTH RELEVANCE: Core A, under Dr. Wright, will provide scientific leadership, insuring coordination and integration among projects and cores. Core A will provide administrative leadership directing the administration of research funds and maintaining compliance with all relevant federal regulations.

描述（由申请人提供）：行政核心促进知识活动，通过研讨会和务虚会计划未来研究的场所以及对研究和支出的监督。该核心还提供了与哈佛大学公共卫生学院内外机构合作的工具，以利用超级基础研究计划的潜力来翻译我们的研究结果，并促进有关混合物，基因环境相互作用以及环境中金属运动的研究。行政核心的具体目的是：目标1-研究 - 监视研究进度，协调内部咨询委员会（治理委员会）会议，并在SBRP计划中以及其他哈佛大学附属机构和协作机构中培养合作研究，例如MIT；目标2-沟通 - 促进EPA 1区（达特茅斯，布朗，波士顿大学）和EPA，ATSDR和小儿环境健康亚科单位（PEHSUS）等机构之间的哈佛SBRP和SBRP计划之间的沟通，并保持与美国国家环境健康科学研究所的密切沟通；目标3可提供必要的资源和财政监督；目标4-以促进重大研究结果的快速传播；并瞄准5-合规 - 确保符合NIH对数据和资源共享的要求以及人类和动物机构审查委员会的要求公共卫生相关性：在赖特博士领导下的核心A将提供科学领导，确保项目和核心之间的协调和整合。核心A将提供指导研究基金管理并维持所有相关联邦法规的行政领导。