BLRD Research Career Scientist Award Application

BLRD 研究职业科学家奖申请

• 批准号: 10696603
• 负责人: Jie Fan
• 金额: --
• 依托单位: VETERANS HEALTH ADMINISTRATION
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10696603
• 关键词: Acute; Acute Lung Injury; American; Area; Autoimmune Diseases; Award; Basic Science; Biological Sciences; Brain Injuries; Cause of Death; Cell Death; Cell Differentiation process; Cells; Cessation of life; Chronic; Clinical; Clinical Research; Collaborations; Communication; Development; Disease; Doctor of Medicine; Doctor of Philosophy; Education; European; Faculty; Failure; Functional disorder; Funding; Goals; Government; Grant Review; Health; Healthcare; Healthcare Systems; Hemorrhage; Hepatology; IACUC; Immunology; Infection; Inflammation; Institution; International; Intervention; Journals; Laboratories; Literature; Medical; Medicine; Mentors; Molecular; Natural Immunity; Nature; Operative Surgical Procedures; Organ; Paper; Pathogenesis; Patients; Peer Review; Pharmaceutical Preparations; Phase; Physicians; Play; Postdoctoral Fellow; Principal Investigator; Productivity; Publications; Publishing; Reporting; Research; Research Personnel; Research Project Grants; Review Committee; Role; Science; Scientist; Sepsis; Signal Transduction; Spinal Injuries; Stroke; Study Section; Systemic Inflammatory Response Syndrome; Therapeutic Intervention; Time; Trauma; Trauma patient; United States National Institutes of Health; Universities; Veterans; Work; career; career development; clinical investigation; editorial; frontier; human disease; member; military veteran; mortality; new therapeutic target; novel; patient population; peer; post-trauma; prevent; preventive intervention; programs; prophylactic; senior faculty; septic patients; surgical research; symposium; therapy development; visiting scholar

PROJECT SUMMARY Jie Fan, M.D., M.Sc. has been working in the VA Pittsburgh Healthcare System (VAPHS) since 2003 and is a VA Research Career Scientist, a Director of the Surgical Research Program, a Vice- Chair of the Institutional Animal Care and Use Committee, a Mentor of VA Career Development Awardees at VAPHS, and a tenured Full Professor of Surgery and Immunology in the Departments of Surgery and Immunology at the University of Pittsburgh. He is a Principal Investigator working on the cellular and molecular mechanisms of post-trauma and post-sepsis systemic inflammatory response syndrome (SIRS) and acute lung injury (ALI), an important but exceptionally difficult area. His laboratory has been continuously funded by VA merit review grants since 2007 and NIH research grants (R01, P50, and R56) since 2005. The burden of trauma- and sepsis-related diseases is considerable in veterans. Following exsanguination and/or brain injury that commonly result in early phase death, more than 60% of surviving patients later die of causes related to the development of SIRS, sepsis, and ALI. This patient population is well suited for prophylactic interventions aimed at preventing these occurrences because of the time lag before the onset of organ inflammation and failure. Nonetheless, few specific targets have been identified that predispose to SIRS and ALI. The long-term goal of Dr. Fan's studies is to provide a new understanding of the mechanisms of post-trauma/post-infection inflammation and organ dysfunction and to develop novel preventive and therapeutic interventions in SIRS, sepsis, and ALI. The studies by Dr. Fan's team will also provide a greater understanding of the pathogenesis of multiple human diseases in which inflammation plays a central role. ALI is one of the common endpoints of SIRS and sepsis. SIRS and sepsis are common causes of mortality following surgery, infection, spinal injury, stroke, hemorrhage, and trauma in the veteran population. And thus, Dr. Fan's research is highly relevant to veterans' health. Dr. Fan is a highly productive Principal Investigator with a long track record of both VA and NIH funding. He has also served in roles such as Co-Investigator, Consultant, and Collaborator on numerous other's research grants. His research and collaborations have resulted in 136 peer-reviewed publications, many of them in the first-line scientific journals, including Nature Medicine, Nature Communications, Journal of Clinical Investigation, Hepatology, Journal of Hepatology, Cell Death & Differentiation, and Journal of Immunology. Dr. Fan's work is renowned by his peers nationally and internationally. He has been an invited speaker at numerous national and international conferences and at many research and educational institutions. He serves as a regular or Ad Hoc member in a number of national peer-review committees, including NIH, VA, DoD, American Institution of Biological Sciences study sections, and European scientific institutions. He also serves as an editor-in-chief, member of editorial board, and invited reviewer for over 50 scientific journals. He has mentored 33 VA and VA WOC trainees including VA Career Development Awardee, surgery residents, Ph.D. candidates, postdoctoral fellows, and visiting scholars, many of whom have now become independent scientists or physician-scientists.

项目概要 范杰，医学博士、硕士一直在 VA 匹兹堡医疗系统 (VAPHS) 工作 2003 年担任 VA 研究职业科学家、外科研究项目主任、副教授 机构动物护理和使用委员会主席、VA 职业发展导师 VAPHS 获奖者以及以下系的外科和免疫学终身正教授 匹兹堡大学的外科和免疫学。他是一名首席研究员，致力于 创伤后和脓毒症后全身炎症反应的细胞和分子机制 综合征（SIRS）和急性肺损伤（ALI），这是一个重要但异常困难的领域。他的 自 2007 年以来，该实验室一直受到 VA 绩效审查补助金和 NIH 研究的持续资助 自 2005 年起拨款（R01、P50 和 R56）。 创伤和败血症相关疾病的负担对退伍军人来说是相当大的。下列的 失血和/或脑损伤通常会导致早期死亡，超过 60% 幸存的患者后来死于与 SIRS、败血症和 ALI 相关的原因。这位患者 人群非常适合旨在预防这些情况发生的预防性干预措施，因为 器官炎症和衰竭发生之前的时间滞后。尽管如此，具体目标却很少 已被确定为 SIRS 和 ALI 的易感因素。范博士研究的长远目标是 提供对创伤后/感染后炎症和器官机制的新认识 功能障碍并开发针对 SIRS、脓毒症和 ALI 的新型预防和治疗干预措施。 范博士团队的研究也将让我们对多种疾病的发病机制有更深入的了解。 炎症在其中起核心作用的人类疾病。 ALI 是 SIRS 和脓毒症的常见终点之一。 SIRS 和脓毒症是导致以下疾病的常见原因 退伍军人手术、感染、脊柱损伤、中风、出血和创伤后的死亡率 人口。因此，范博士的研究与退伍军人的健康密切相关。 范博士是一位高产的首席研究员，在 VA 和 NIH 都有长期的工作记录 资金。他还担任过联合研究员、顾问和合作者等职务 许多其他人的研究资助。他的研究和合作产生了 136 项经过同行评审的论文 发表论文，其中许多发表在一线科学期刊上，包括 Nature Medicine、Nature 通讯、临床研究杂志、肝病学、肝病学杂志、细胞死亡与 分化和免疫学杂志。范博士的工作在全国同行中享有盛誉， 国际上。曾多次受邀在国内和国际会议上发表演讲 在许多研究和教育机构。他担任多个组织的正式成员或临时成员 国家同行评审委员会，包括 NIH、VA、DoD、美国生物科学研究所 研究部门和欧洲科研机构。他还担任主编、成员 50多种科学期刊的编委和特邀审稿人。 他指导了 33 名 VA 和 VA WOC 学员，包括 VA 职业发展奖获得者、 外科住院医师，博士候选人、博士后研究员和访问学者，其中许多人拥有 现在成为独立科学家或医师科学家。