BLR&D Research Career Scientist Award Application

BLR

• 批准号: 10265421
• 负责人: Jie Fan
• 金额: --
• 依托单位: VETERANS HEALTH ADMINISTRATION
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10265421
• 关键词: Acute; Acute Lung Injury; Alveolar Macrophages; American; Animals; Area; Autoimmune Diseases; Award; Biological Sciences; Brain Injuries; Cause of Death; Cell Death; Cell Differentiation process; Cells; Cessation of life; Chronic; Collaborations; Communication; Development; Disease; Doctor of Medicine; Doctor of Philosophy; Faculty; Failure; Functional disorder; Funding; Goals; Government; Grant Review; Health; Healthcare; Healthcare Systems; Hemorrhage; Hemorrhagic Shock; Hepatology; Immunology; Infection; Inflammasome; Inflammation; Institution; Interleukin-1; International; Intervention; Journals; Laboratories; Literature; Mediating; Medical; Medicine; Mentors; Molecular; Natural Immunity; Nature; Operative Surgical Procedures; Organ; Pathogenesis; Patients; Peer Review; Peptides; Permeability; Phase; Physicians; Play; Postdoctoral Fellow; Principal Investigator; Publications; Research; Research Personnel; Research Project Grants; Review Committee; Role; Science; Scientist; Sepsis; Signal Pathway; Signal Transduction; Spinal Injuries; Stroke; Study Section; Systemic Inflammatory Response Syndrome; Therapeutic Intervention; Time; Toll-like receptors; Trauma; Trauma patient; United States National Institutes of Health; Universities; Veterans; Work; base; career; clinical investigation; cytokine; editorial; human disease; improved; institutional biosafety committee; member; military veteran; mortality; multidisciplinary; new therapeutic target; novel; patient population; peer; post-trauma; prevent; preventive intervention; programs; prophylactic; protein complex; senior faculty; surgical research; survival outcome; symposium; therapy development; visiting scholar

PROJECT SUMMARY Jie Fan, M.D., M.Sc. has been working in the VA Pittsburgh Healthcare System (VAPHS) since 2003, and is a Director of the Multidisciplinary Surgical Research Program, a Vice Chair of the Institutional Biosafety Committee in VAPHS, and a tenured Full Professor of the Department of Surgery at the University of Pittsburgh. He is a Principal Investigator working on the cellular and molecular mechanisms of sepsis, post-trauma systemic inflammatory response syndrome (SIRS) and acute lung injury (ALI), an important but exceptionally difficult area. His laboratory has been funded by two VA merit review grants and four NIH research grants (R01, P50, and R56). The burden of trauma-related diseases is considerable. Following exsanguination and/or brain injury that commonly result in early phase death, more than 60% of surviving patients later die of causes related to the development of SIRS, sepsis, and ALI. This patient population is well suited for prophylactic interventions aimed at preventing these occurrences because of the time lag before the onset of organ inflammation and failure. Nonetheless, few specific targets have been identified that predispose to SIRS and ALI. The long term goal of Dr. Fan’s studies is to provide a new understanding of the mechanisms of post-trauma inflammation and organ dysfunction, and therefore, to potentially provide novel targets for preventive and therapeutic interventions in post-trauma SIRS, sepsis, and ALI. The studies by Dr. Fan’s team will also provide a greater understanding of the pathogenesis of multiple human diseases in which inflammation plays a central role. ALI is one of the common endpoints of SIRS and sepsis. SIRS and sepsis are common causes of mortality following surgery, infection, spinal injury, stroke, hemorrhage, and trauma in the veteran population. And thus, Dr. Fan’s research is highly relevant to Veterans’ health. Dr. Fan’s research provides critical information that can be used toward the development of therapies for veterans with post-trauma inflammation and ALI. He is a highly productive Principal Investigator with a long track record of both VA and NIH funding. He has also served in roles such as Co-Investigator, Consultant, and Collaborator on numerous other research grants. His research and collaborations have resulted in 113 peer-reviewed publications, many of them in the best scientific journals and with high impact factors, including Nature Medicine, Nature Communications, Journal of Clinical Investigation, Hepatology, Journal of Hepatology, Cell Death & Differentiation, and Journal of Immunology. Dr. Fan’s work is renowned by his peers nationally and internationally. He has been an invited speaker at numerous national and international conferences and at many research and educational institutions. He serves as a reviewer in a number of national peer-review committees, including VA, NIH, DoD, and American Institution of Biological Sciences study sections. He also serves as editor-in-chief, member of editorial board, and invited reviewer for over 50 scientific journals. He has mentored 27 VA and non-VA trainees including Ph.D. candidates, postdoctoral fellows, residents, junior surgery faculties, and visiting scholars, many of whom have now become independent scientists or physician scientists. Dr. Fan is a 2010 recipient of the Excellence in Government Award for Outstanding Contribution to Medical Sciences.

项目概要 范杰，医学博士，硕士，自 2017 年起一直在 VA 匹兹堡医疗系统 (VAPHS) 工作 2003 年，担任多学科外科研究项目主任、 VAPHS机构生物安全委员会和外科系终身正教授 他是匹兹堡大学的首席研究员，从事细胞和分子研究。 脓毒症、创伤后全身炎症反应综合征（SIRS）和急性肺的机制 损伤（ALI），一个重要但异常困难的领域，他的实验室得到了两个 VA 的资助。 绩效评审补助金和四项 NIH 研究补助金（R01、P50 和 R56）。 失血和/或大脑失血后，与创伤相关的疾病的负担是相当大的。 通常导致早期死亡的损伤，超过 60% 的幸存患者后来死于 与 SIRS、脓毒症和 ALI 的发展相关的原因 该患者人群非常适合。 由于发生前存在时间滞后，因此应采取预防性干预措施来防止这些情况的发生 然而，几乎没有确定器官炎症和衰竭的发生。 范博士研究的长期目标是提供新的认识。 创伤后炎症和器官功能障碍的机制，因此，可能 为创伤后 SIRS、败血症和 ALI 的预防和治疗干预提供新的靶标。 范博士团队的研究也将让我们对多种疾病的发病机制有更深入的了解。 炎症在其中起核心作用的人类疾病。 ALI 是 SIRS 的常见终点之一，而脓毒症是 SIRS 的常见原因。 退伍军人手术、感染、脊柱损伤、中风、出血和创伤后的死亡率 因此，范博士的研究与退伍军人的健康高度相关。 范博士的研究提供了可用于开发的关键信息 为患有创伤后炎症和急性肺损伤的退伍军人提供治疗。他是一位高效的校长。 作为一名长期从事 VA 和 NIH 资助记录的研究员，他还曾担任过以下职务。 他的研究和研究项目的共同研究员、顾问和合作者。 合作已产生 113 份经过同行评审的出版物，其中许多发表在最好的科学期刊上 影响因子较高的期刊，包括 Nature Medicine、Nature Communications、Journal of 临床研究、肝病学、肝病学杂志、细胞死亡与分化、以及肝病学杂志 范博士的工作在国内外同行中享有盛誉。 在许多国内和国际会议以及许多研究和会议上受邀演讲 他担任多个国家同行评审委员会的评审员， 他还服务于 VA、NIH、DoD 和美国生物科学研究所的研究部门。 担任50余种科学期刊的主编、编委、特邀审稿人。 指导了 27 名 VA 和非 VA 学员，包括博士生、博士后研究员、住院医师、初级医师 外科教师和访问学者，其中许多人现已成为独立科学家或 范博士是 2010 年杰出政府卓越奖获得者。 对医学科学的贡献。