IMMUNOLOGICAL AND GENETIC ANALYSIS OF AUTOINFLAMMATORY GENES IN FIBROMYALGIA

纤维肌痛自身炎症基因的免疫学和遗传学分析

• 批准号: 7603880
• 负责人: John Ernest Shively
• 金额: $ 5.72万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603880
• 关键词: Affect; Biological Assay; Computer Retrieval of Information on Scientific Projects Database; Diagnosis; Diagnostic Procedure; Disease; Exons; Family; Female; Fibromyalgia; Funding; Genes; Genetic Polymorphism; Grant; Immigration; Institution; Parents; Patients; Population; Purpose; Research; Research Personnel; Resources; Source; Standards of Weights and Measures; Stimulus; Syndrome; United States National Institutes of Health; cytokine; genetic analysis; neutrophil; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Purpose: to determine if patients with fibromyalgia have hyperactive neutrophils and/or carry genetic polymorphisms in newly discovered autoinflammatory genes (pyringene family). Assessment: (1) Compare response of patient neutrophils vs controls to various stimuli in migration, invasion, and cytokine release assays. (2) Sequence exons of five autoinflammatory genes and determine if polymorphisms are shared among patients and their parents vs control. Significance: this is a common syndrome (affecting 2 to 6% of the US population) predominantly in females (85%) that has no known cause or standard treatment. The diagnosis is made on tender point examination. If we can demonstrate that polymorphisms in autoinflammatory genes are causative and that neutrophil assays can diagnose the disease, new treatments an diagnostic procedures could be devised.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 目的：确定纤维肌痛的患者是否具有多活跃性中性粒细胞和/或携带新发现的自发性基因（肾上黄酮家庭）中的遗传多态性。 评估：（1）将患者中性粒细胞与对照组的反应与迁移，入侵和细胞因子释放分析中的各种刺激进行比较。 （2）五个自身炎性基因的序列外显子，并确定患者及其父母与对照中是否共享多态性。 意义：这是一种普通综合征（影响美国人口的2至6％），主要是女性（85％），没有已知原因或标准治疗。 诊断是在招标点检查中进行的。 如果我们可以证明自炎基因中的多态性是病因，并且中性粒细胞分析可以诊断疾病，那么可以设计诊断程序的新治疗方法。