Integrating the Social Context, Sensory Functioning, and Inflammation in a Longitudinal Study of Cognitive Aging and Alzheimer's Disease and Related Dementias

将社会环境、感觉功能和炎症纳入认知衰老和阿尔茨海默病及相关痴呆症的纵向研究

• 批准号: 10670984
• 负责人: Alyssa Goldman
• 金额: $ 12.65万
• 依托单位: BOSTON COLLEGE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10670984
• 关键词: Age-associated memory impairment; Aging; Alzheimer' s disease diagnosis; Alzheimer' s disease related dementia; Area; Award; Biological; Brain; Buffers; Chronic; Cognition; Cognitive; Cognitive aging; Data; Development; Diagnosis; Disease; Disparity; Distal; Elderly; Exposure to; Family; Future; Goals; Grant; Health; Home; Impaired cognition; Inflammation; Inflammatory Response; Infrastructure; Intervention; Knowledge; Life; Link; Longitudinal Studies; Measures; Mentored Research Scientist Development Award; Mentorship; Methods; Neighborhoods; Pathway interactions; Patients; Physiological; Physiology; Population Study; Prevalence; Process; Public Health; Research; Research Activity; Research Design; Research Personnel; Risk; Role; Sampling; Sensory; Shapes; Site; Smell Perception; Social Characteristics; Social Environment; Social Network; Social support; Source; Survey Methodology; Time; Training; Training Activity; United States; Vision; Work; Writing; age related; analytical method; burden of illness; career; cognitive ability; cognitive function; experience; improved; innovation; insight; longitudinal analysis; middle age; novel; prevent; programs; rapid growth; sensory system; skills; social; social determinants; social factors; social learning; social relationships; social science research; sociologist; theories

PROJECT SUMMARY/ABSTRACT Research into cognitive impairments and Alzheimer’s disease and related dementias (ADRD) suggests that exposure to enriching or stimulating social contexts – i.e., social complexity – may slow age-related cognitive decline and delay the onset or progression of ADRD. Most research in this area has considered how social complexity in either the proximal (e.g., social network, social activities) or distal (e.g., neighborhood) contexts shape cognition. Additionally, prior research on social complexity and cognition is conducted largely separately from existing physiological frameworks for understanding cognitive aging and ADRD. Through this K01, Dr. Alyssa Goldman will integrate existing research on the roles of sensory systems and inflammation in shaping cognitive decline and ADRD, and examine how these associations are informed by changes in both proximal and distal social complexity over time. Dr. Goldman’s long-term goal is to lead a social science research program that uses innovative approaches to better understand the social pathways of cognitive functioning and ADRD. The K01 Award will support this goal by extending her prior training as a sociologist, developing her understanding of and skills in: (1) the physiology of cognitive aging, ADRD, sensory functioning, and inflammation, (2) the objective assessment of cognition, sensory functioning, and inflammation through large- scale, in-home survey methods, (3) advanced methods for longitudinal analysis, and (4) grant writing and professional development. In parallel with this training, this project has three research aims: (1) to determine how changes in exposure to proximal and distal social complexity collectively shape cognition and ADRD, (2) to determine how proximal and distal social complexity are associated with olfaction, in ways that may shape trajectories of cognition and ADRD, and (3) to determine how proximal and distal social complexity are associated with inflammation, in ways that may explain changes in cognition and ADRD. The training and research goals of this proposal will be overseen by a mentorship committee of accomplished experts in cognition and ADRD, sensory systems, chronic inflammation, and aging and the social context. This study will generate new insights on the collective impact of proximal and distal social factors on cognitive decline and ADRD. Further, this study will examine how social complexity shapes trajectories of olfaction and inflammation as mechanisms in the relationship between social complexity and cognitive health in a nationally-representative sample of older adults. These physiological frameworks of cognition and ADRD have yet to be contextualized in terms of social factors. This study will develop innovative measures of social network change, which are largely undertheorized, and that can be applied to future studies of cognitive aging and other health trajectories. The training and research activities of this award will equip Dr. Goldman with the skills to succeed as an independent investigator of the social context of sensory systems, disease processes, and their relationships with cognition and ADRD.

项目概要/摘要 对认知障碍和阿尔茨海默病及相关痴呆 (ADRD) 的研究表明 接触丰富或刺激的社会环境（即社会复杂性）可能会减缓与年龄相关的认知能力 该领域的大多数研究都考虑了社交如何减少和延缓 ADRD 的发生或进展。 近端（例如社交网络、社交活动）或远端（例如邻居）环境的复杂性 此外，先前关于社会复杂性和认知的研究基本上是分开进行的。 通过这个 K01，Dr. 从现有的生理框架中了解认知衰老和 ADRD。 艾莉莎·戈德曼（Alyssa Goldman）将整合关于感觉系统和炎症在塑造中的作用的现有研究 认知能力下降和ADRD，并研究这些关联是如何通过近端认知功能的变化来了解的 戈德曼博士的长期目标是领导一个社会科学研究项目。 使用创新方法更好地了解认知功能和 ADRD 的社会途径。 K01 奖将通过扩展她之前作为社会学家的培训、发展她的能力来支持这一目标 对以下方面的理解和技能：(1) 认知衰老的生理学、ADRD、感觉功能，以及 炎症，（2）通过大范围客观评估认知、感觉功能和炎症 量表、家庭调查方法、(3) 纵向分析的高级方法，以及 (4) 拨款写作和 与此培训同时进行的，该项目还有三个研究目标：(1) 确定。 近端和远端社会复杂性的变化如何共同塑造认知和ADRD，(2) 确定近端和远端社会复杂性如何与嗅觉相关，其方式可能会影响嗅觉 认知和 ADRD 的轨迹，以及 (3) 确定近端和远端社会复杂性的程度 与炎症有关，可以解释认知和 ADRD 的变化。 该提案的研究目标将由认知领域知名专家组成的指导委员会监督 ADRD、感觉系统、慢性炎症、衰老和社会背景。 关于近端和远端社会因素对认知衰退和 ADRD 的集体影响的新见解。 这项研究将探讨社会复杂性如何塑造嗅觉和炎症的轨迹作为机制 在具有全国代表性的老年人样本中，社会复杂性与认知健康之间的关系 这些认知和 ADRD 的生理框架尚未在社会层面上具体化。 这项研究将开发社交网络变化的创新措施，这些措施在很大程度上缺乏理论依据， 这可以应用于未来的认知衰老和其他健康轨迹研究。 该奖项的研究活动将使戈德曼博士具备作为独立研究者取得成功的技能 感觉系统的社会背景、疾病过程及其与认知和 ADRD 的关系。