Postdoctoral Training Program in Genomic Medicine

基因组医学博士后培养项目

基本信息

批准号：
10668462
负责人：
Katherine L. Nathanson
金额：
$ 24.99万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-07-21 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10668462
关键词：
Genomic medicine Training Programs post-doctoral training

项目摘要

Genomics technology is sufficiently advanced to measure DNA sequence variation and RNA expression in clinical samples. However, the integration of genomic measurements into healthcare is outpacing the training of physicians and scientists, and many are ill-equipped to use this information to improve the health of patients. Thus, it is imperative to train the next generation of physician and scientist leaders in Genomic Medicine. We propose to renewal our post-doctoral training program in Genomic Medicine focuses on translational medicine and informatics and is led by Drs. Jason Moore, Edward Rose Professor of Informatics, and Director of the Penn Institute for Biomedical Informatics, and Katherine Nathanson, Pearl Basser Professor of BRCA-Related Research, and Deputy Director, Abramson Cancer Center. We provide a foundation for training in Genomic Medicine, applicable to both MD and PhD trained fellows, recognizing that each may enter the program with different skill sets and experiences. It essential to provide all fellows with a strong background framework so that they can develop exciting and relevant projects in Genomic Medicine. Trainees enroll in a two-year program, including didactic courses, clinical and laboratories rotations, interactive learning experiences and research training. We require a balanced portfolio of courses, which cover the latest advances in genomics, focused on the role of genomics in disease processes, quantitative sciences, including biomedical informatics and biostatistics, scientific writing and ELSI issues. The 39 trainers were selected based on their expertise in Genomic Medicine and come from multiple departments, which is further enlarged with clinicians experienced in the provision of Genomic Medicine. The trainees are dually mentored in a research project by a balanced team (e.g. clinician and basic scientist) experienced in Genomic Medicine. Trainees participate in clinical rotations designed to give them experiences that range from the generation of massively parallel sequence data to data analysis to reporting back the results to patients. Trainees also participate in interactive activities, including a journal club, research in progress presentations, clinical genetics rounds and retreats. The combination of coursework, experiential clinical rotations, participation in interactive activities, and mentored research experience prepares our physicians and scientists for careers in Genomic Medicine. Over the past five years, 14 individuals were accepted (42% of applicants) into the Genomic Medicine program - eight physicians, six scientists, from 10 different departments and divisions at Penn Medicine (nine) and CHOP (five). Nine (64%) of our trainees were women and three (21%) reported coming from underrepresented populations. We have been privileged to attract an exceptionally strong and diverse set of trainees and anticipate continuing to be able to do so. We request continued support for the entry of three trainees a year in the Genomic Medicine T32 post-doctoral training program at the University of Pennsylvania.

基因组学技术足够先进，可以测量 DNA 序列变异和 RNA 表达临床样本。然而，基因组测量与医疗保健的整合速度超过了培训速度医生和科学家的知识，其中许多人没有能力利用这些信息来改善患者的健康。因此，培养基因组医学领域的下一代医生和科学家领导者势在必行。我们建议更新我们的基因组医学博士后培训计划，重点关注转化医学和信息学，由博士领导。贾森·摩尔 (Jason Moore)，爱德华·罗斯 (Edward Rose) 信息学教授，兼宾夕法尼亚大学生物医学信息学研究所和 Katherine Nathanson，BRCA 相关的 Pearl Basser 教授艾布拉姆森癌症中心研究兼副主任。我们为基因组培训提供基础医学，适用于医学博士和博士培训人员，认识到每个人都可以进入该计划不同的技能和经验。为所有研究员提供强大的背景框架至关重要，以便他们可以在基因组医学领域开发令人兴奋的相关项目。学员报名参加为期两年的计划，包括教学课程、临床和实验室轮换、互动学习体验和研究培训。我们需要平衡的课程组合，涵盖基因组学的最新进展，专注于基因组学在疾病过程、定量科学（包括生物医学信息学）中的作用以及生物统计学、科学写作和 ELSI 问题。这 39 名培训师是根据他们的专业知识选出的基因医学，来自多个科室，临床医生经验丰富，进一步扩大提供基因组医学。学员在研究项目中接受平衡的双重指导具有基因组医学经验的团队（例如临床医生和基础科学家）。学员参加临床旨在为他们提供从生成大规模并行序列的体验到的轮换从数据到数据分析，再到向患者报告结果。学员们还参与互动活动，包括期刊俱乐部、进展研究演示、临床遗传学查房和务虚会。这结合课程作业、体验式临床轮转、参与互动活动和指导研究经验为我们的医生和科学家在基因组医学领域的职业生涯做好准备。过去的事五年来，14 人（占申请者的 42%）被基因组医学项目录取——其中 8 人来自 Penn Medicine（9 个）和 CHOP 10 个不同科室的医生、6 名科学家（五）。我们的学员中有九名 (64%) 是女性，其中三名 (21%) 来自代表性不足的地区人口。我们很荣幸能够吸引一批非常强大且多样化的学员，预计能够继续这样做。我们请求继续支持每年三名学员进入宾夕法尼亚大学基因组医学 T32 博士后培训项目。

项目成果

期刊论文数量（49）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Walking Away From Heart Failure.

远离心力衰竭。

DOI：
发表时间：
2018
期刊：
影响因子：
0
作者：
Jessup, Mariell;Reza, Nosheen
通讯作者：
Reza, Nosheen

ACTA1 Novel Likely Pathogenic Variant in a Family With Dilated Cardiomyopathy.

ACTA1 扩张型心肌病家族中可能存在的新型致病变异。

DOI：
发表时间：
2018
期刊：
影响因子：
0
作者：
Reza, Nosheen;Garg, Ankit;Merrill, Shana L;Chowns, Jessica L;Rao, Sriram;Owens, Anjali Tiku
通讯作者：
Owens, Anjali Tiku

Reversible Coronary Artery Aneurysm With Delayed Anti-inflammatory Therapy in Multisystem Inflammatory Syndrome in Children.

儿童多系统炎症综合征的可逆性冠状动脉瘤与延迟抗炎治疗。

DOI：
发表时间：
2021-04
期刊：
影响因子：
0
作者：
Shaykh, Ramzi;Leftin, Shoshana;Suh, Sanghee;Spencer, Robert;Gorelik, Mark;Wilson, Patrick T;Diamond, Rebekah
通讯作者：
Diamond, Rebekah

Pediatric pulmonology year in review 2021 and 2022: Physiology.

2021 年和 2022 年儿科肺病学年度回顾：生理学。