AN EXERCISE INTERVENTION IN INSULIN-RESISTANT MINORITY ADOLESCENTS

对胰岛素抵抗的少数青少年的运动干预

• 批准号: 7717168
• 负责人: ERIC P. HOFFMAN
• 金额: $ 4.59万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7717168
• 关键词: Adolescent; Adult; African American; American; Attenuated; Child; Childhood; Computer Retrieval of Information on Scientific Projects Database; Development; Exercise; Funding; Grant; Hispanics; Hyperinsulinism; Incidence; Institution; Insulin Resistance; Intervention; Minority; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Physical activity; Play; Population; Prevalence; Puberty; Research; Research Personnel; Resources; Risk; Risk Factors; Role; Source; Training; United States National Institutes of Health; girls; insulin sensitivity; prevent

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The increased incidence of pediatric type 2 diabetes parallels increased prevalence of obesity. Obesity is commonly accompanied by insulin resistance and hyperinsulinemia, which precedes and plays a major role in the development of type 2 diabetes. This phenomenon may be related with the fact that American adolescents, especially girls, are now becoming less physically active in early puberty, explaining the largely pubertal and post-pubertal onset of type 2 diabetes in adolescents. Although regular physical activity has been suggested to attenuate obesity and prevent type 2 diabetes in high-risk children and adolescents, the magnitude of exercise training-induced improvement in the risk factors for type 2 diabetes has been only recently studied in adults and not studied in pediatric populations. The objectives of this study are: 1) to determine the effects of exercise on insulin sensitivity in insulin-resistant African-American and Hispanic adolescents and 2) to determine the effects of exercise on fibrinolytic markers in insulin-resistant African-American and Hispanic adolescents.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 小儿2型糖尿病的发生率增加，肥胖症患病率增加。肥胖通常伴随着胰岛素抵抗和高胰岛素血症，在2型糖尿病的发展中起着主要作用。这种现象可能与以下事实有关：美国青少年，尤其是女孩，现在在青春期早期变得越来越活跃，这解释了青少年中2型糖尿病的大量青春期和青春期后发作。尽管已建议定期进行体育锻炼来减轻肥胖症并预防高危儿童和青少年的2型糖尿病，但仅在成年人中才研究了2型2型糖尿病危险因素的运动训练所引起的改善，并在儿科种群中进行了研究。这项研究的目的是：1）确定运动对耐胰岛素抵抗胰岛素的非裔美国人和西班牙裔青少年的胰岛素敏感性的影响，以及2）确定运动对胰岛素抵抗胰岛素的非裔美国人和西班牙裔青少年中纤维蛋白分解标记的影响。