AN EXERCISE INTERVENTION IN INSULIN-RESISTANT MINORITY ADOLESCENTS

对胰岛素抵抗的少数青少年的运动干预

• 批准号: 8167332
• 负责人: ERIC P. HOFFMAN
• 金额: $ 1.17万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-20 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167332
• 关键词: Adolescent; Adult; African American; American; Attenuated; Child; Childhood; Computer Retrieval of Information on Scientific Projects Database; Development; Exercise; Funding; Grant; Hispanics; Hyperinsulinism; Incidence; Institution; Insulin Resistance; Intervention; Minority; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Physical activity; Play; Population; Prevalence; Puberty; Research; Research Personnel; Resources; Risk Factors; Role; Source; Training; United States National Institutes of Health; girls; high risk; insulin sensitivity; prevent

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The increased incidence of pediatric type 2 diabetes parallels increased prevalence of obesity. Obesity is commonly accompanied by insulin resistance and hyperinsulinemia, which precedes and plays a major role in the development of type 2 diabetes. This phenomenon may be related with the fact that American adolescents, especially girls, are now becoming less physically active in early puberty, explaining the largely pubertal and post-pubertal onset of type 2 diabetes in adolescents. Although regular physical activity has been suggested to attenuate obesity and prevent type 2 diabetes in high-risk children and adolescents, the magnitude of exercise training-induced improvement in the risk factors for type 2 diabetes has been only recently studied in adults and not studied in pediatric populations. The objectives of this study are: 1) to determine the effects of exercise on insulin sensitivity in insulin-resistant African-American and Hispanic adolescents and 2) to determine the effects of exercise on fibrinolytic markers in insulin-resistant African-American and Hispanic adolescents.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 儿童 2 型糖尿病发病率的增加与肥胖患病率的增加相一致。肥胖通常伴有胰岛素抵抗和高胰岛素血症，这先于 2 型糖尿病的发生并在 2 型糖尿病的发生中发挥重要作用。这种现象可能与美国青少年，尤其是女孩，在青春期早期体力活动减少有关，这解释了青少年2型糖尿病主要在青春期和青春期后发病的情况。尽管有规律的体力活动被认为可以减轻高危儿童和青少年的肥胖并预防 2 型糖尿病，但运动训练引起的 2 型糖尿病危险因素改善程度最近才在成人中进行了研究，而在儿科人群。本研究的目的是：1) 确定运动对胰岛素抵抗的非裔美国人和西班牙裔青少年胰岛素敏感性的影响，2) 确定运动对胰岛素抵抗的非裔美国人和西班牙裔青少年纤溶标志物的影响。