Identifying interconnections of the disparities in childhood obesity

确定儿童肥胖差异之间的相互关系

• 批准号: 10654256
• 负责人: Geetha Thangiah
• 金额: $ 44.15万
• 依托单位: AUBURN UNIVERSITY AT AUBURN
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-03 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10654256
• 关键词: 8-hydroxy-2' -deoxyguanosine; Adipocytes; Adolescent obesity; Adult; African American; African American population; Age; Alabama; American; Asthma; Behavior; Biological Markers; Biomedical Research; Body mass index; C-reactive protein; COVID-19; Cardiovascular Diseases; Caucasians; Cells; Centers for Disease Control and Prevention (U.S.); Child; Data; Discipline; Disease; Disparity; Early identification; Education; Environment; Environmental Risk Factor; Enzyme-Linked Immunosorbent Assay; Epidemic; Ethnic Origin; European; Family; Functional disorder; Future; Gas Chromatography; Genetic; Goals; Health; Health Disparities Research; Human body; Hydrogen Peroxide; Income; Inflammatory; Interleukin-6; Isoprostanes; Knowledge; Linear Regressions; Lipid Peroxidation; Low Income Population; Malignant Neoplasms; Mass Spectrum Analysis; Measurement; Metabolic; Microbe; Modeling; Non-Insulin-Dependent Diabetes Mellitus; Not Hispanic or Latino; Obesity; Orosomucoid; Outcome; Overweight; Oxidative Stress; Oxidative Stress Induction; Parenting Education; Parents; Pattern; Phase; Play; Poverty; Prevalence; Production; Race; Reaction; Reactive Oxygen Species; Research; Research Personnel; Role; Rural; Sampling; Scientist; Socioeconomic Status; Solid; Students; Techniques; Testing; United States; Urine; Weight; Work; aged; career; college; ethnic difference; ethnic disparity; experience; gain of function; graduate student; health disparity; high risk; inflammatory marker; literacy; loss of function; lower income families; mass spectrometer; minority children; obesity in children; racial difference; racial disparity; recruit; sex; stress state; undergraduate student; urinary; volatile organic compound

PROJECT SUMMARY/ABSTRACT: Childhood obesity is a serious concern, particularly in low literacy and low-income populations among minority children. Obese children are at higher risk of developing type 2 diabetes, cardiovascular disease, cancer, asthma, and worse coronavirus disease 2019 (COVID-19) outcomes. Around 36% of children live in poverty, and 42% live in low-income families. There are also racial and ethnic disparities in parent education. 40.4% of non-Hispanic white children have a college-educated parent, compared with 20.3% of non-Hispanic black. The rate of obesity in African Americans is 24.2%, and in whites is at 16.1%. African American adults are found to have high oxidative stress than Caucasians. Several volatile organic compounds (VOCs) are generated by the reactive oxygen species. However, there is significant gap in the research directly examining the association of racial disparities with oxidative stress and VOCs. The overall objective of this study is to determine the association of urinary oxidative stress, volatile organic compounds profile, and oxidative stress-derived VOC metabolites with race/ethnicity and childhood obesity. We plan to accomplish the objective of this application by pursuing the following specific aims. (1) Determine the urinary oxidative stress, VOC metabolites, and oxidative stress-derived VOCs associated with race/ethnic disparity in childhood obesity. (2) Determine if oxidative stress induces the release of VOC metabolites. This research will fundamentally advance our understanding of the association between oxidative stress and the volatile organic compound metabolites with the disparities in childhood obesity. The findings will help reveal the early metabolic non-invasive biomarkers of disparities in childhood obesity. We strongly believe that the direct research experience gained by the undergraduate and graduate students working on this project will help them understand the pathophysiology associated with the disparities in childhood obesity. The successful completion of the study will help the involved students to gain in-depth knowledge of disparities and prepare future scientists to pursue their careers in health-related disciplines.

项目摘要/摘要： 儿童肥胖是一个严重的问题，尤其是在低识字率和低收入人群中 少数民族儿童。肥胖儿童患2型糖尿病，心血管疾病，癌症， 哮喘，冠状病毒疾病2019（COVID-19）的结果。约有36％的儿童生活在贫困中， 和42％的低收入家庭生活。父母教育中也存在种族和种族差异。 40.4％ 非西班牙裔白人儿童有一个受过大学教育的父母，而非西班牙裔黑人则为20.3％。这 非裔美国人的肥胖率为24.2％，白人的肥胖率为16.1％。发现非裔美国人成年人 比高加索人具有高氧化应激。几种挥发性有机化合物（VOC）由 活性氧。但是，研究直接研究了 具有氧化应激和VOC的种族差异。 这项研究的总体目的是确定尿氧化应激，挥发性的关联 有机化合物曲线以及具有种族/种族和童年的氧化应激衍生的VOC代谢产物 肥胖。我们计划通过追求以下特定目标来实现此应用程序的目标。 （1） 确定与与之相关的尿氧化应激，VOC代谢产物和氧化应激衍生的VOC 儿童肥胖症中的种族/种族差异。 （2）确定氧化应激是否诱导了VOC的释放 代谢物。 这项研究从根本上可以提高我们对氧化应激之间关联的理解 以及具有儿童肥胖症差异的挥发性有机复合代谢产物。调查结果将有所帮助 揭示儿童肥胖症差异的早期代谢非侵入性生物标志物。我们坚信 从事该项目的本科生和研究生获得的直接研究经验将 帮助他们了解与儿童肥胖症差异相关的病理生理学。成功 该研究的完成将有助于参与学生获得深入的差异知识并准备 未来的科学家在与健康有关的学科中从事职业。