PROGNOSTIC VALUE OF CLINICAL EXERCISE TESTING WITH VENTILATORY EXPIRED GAS

通气呼出气体临床运动测试的预后价值

• 批准号: 7717019
• 负责人: ROSS A ARENA
• 金额: $ 0.53万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7717019
• 关键词: American; American Heart Association; Cardiac; Cardiology; Caring; Class; Clinical; Computer Retrieval of Information on Scientific Projects Database; Data; Databases; Diagnosis-Related Groups; Evaluation; Exercise stress test; Facility Construction Funding Category; Funding; Gases; Grant; Guidelines; Heart failure; Hospitalization; Hospitals; Individual; Institution; Investigation; Measures; Medicare; Numbers; Outcome; Patient Care; Patients; Personal Satisfaction; Physicians; Population; Procedures; Purpose; Recommendation; Research; Research Personnel; Resources; Source; Standards of Weights and Measures; Symptoms; United States National Institutes of Health; Work; Writing; base; college; improved; mortality; prognostic; skills; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Symptom-limited exercise testing with ventilatory expired gas is an accepted form of evaluation in the heart failure population. There are a number of parameters, beyond peak VO2, which appear to hold clinical value. The purpose of this study is to improve the interpretive skills of clinicians responsible for analysis of this type of data and to apply it in a way that is beneficial to the care of the patient with heart failure, and to prospectively build a database of key variables from standard of care exercise tests in patients with HF and simultaneously assess their individual and combined ability to predict cardiac related hospitalization and mortality over a one-year period. The value of exercise testing in the heart failure (HF) population is well established. Guidelines for exercise testing put forth be the American College of Cardiology and American Heart Association categorize exercise testing with ventilatory expired gas analysis in the HF population as a class I recommendation which is based upon a large number of well controlled investigations supporting its use. To date, there has not been an investigation, which has compared the prognostic significance of all promising ventilatory expired gas parameters simultaneously. Additionally, little work has been done in examining the ability of these parameters to predict outcomes other than mortality. Given that HF is the primary hospital diagnostic related group among Medicare patients, analysis of measures predicting hospitalization in this population seems warranted. Subjects are required to participate in an exercise test with ventilatory expired gas analysis as part of their standard of care as determined by their cardiologist/physician. The session consists of collecting necessary background information, completing all paperwork and written evaluation tools, and undergoing a symptom-limited exercise test. These procedures are identical to what would be performed clinically without a research agenda. The only addition will be the construction of a database to determine the prognostic ability of exercise testing data.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 使用通气呼出气体进行症状限制运动测试是心力衰竭人群公认的评估形式。 除了峰值摄氧量之外，还有许多参数似乎具有临床价值。 本研究的目的是提高负责分析此类数据的临床医生的解释技能，并以有益于心力衰竭患者护理的方式应用它，并前瞻性地建立关键变量的数据库根据心力衰竭患者的标准护理运动测试，同时评估他们预测一年内心脏相关住院和死亡率的个人和综合能力。 运动测试对心力衰竭 (HF) 人群的价值已得到充分证实。 美国心脏病学会和美国心脏协会提出的运动测试指南将心力衰竭人群中使用通气呼出气体分析的运动测试归类为 I 级建议，该建议基于支持其使用的大量受控良好的调查。迄今为止，还没有一项研究同时比较了所有有希望的通气呼出气体参数的预后意义。 此外，在检查这些参数预测死亡率以外的结果的能力方面几乎没有做任何工作。鉴于心力衰竭是医疗保险患者中主要的医院诊断相关群体，似乎有必要对预测该人群住院的措施进行分析。 受试者需要参加运动测试和通气呼出气体分析，作为其心脏病专家/医生确定的护理标准的一部分。 该课程包括收集必要的背景信息、完成所有文书工作和书面评估工具，以及进行症状限制运动测试。 这些程序与没有研究议程的临床执行程序相同。 唯一的补充是建立一个数据库来确定运动测试数据的预测能力。