EFFECT OF AEROBIC EXERCISE TRAINING ON ARTERIAL STIFFNESS IN PATIENTS WITH H

有氧运动训练对 H 患者动脉硬化的影响

• 批准号: 7950876
• 负责人: ROSS A ARENA
• 金额: $ 0.14万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7950876
• 关键词: Activities of Daily Living; Aerobic Exercise; Brain; Carbon Dioxide; Chronic; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Diagnosis; Environmental air flow; Funding; Goals; Grant; Heart failure; Home environment; Institution; Investigation; Measurement; Measures; Outcome; Oxygen Consumption; Patients; Peptides; Perceived quality of life; Physiological; Physiological Adaptation; Production; Research; Research Personnel; Resources; Source; Training; Training Programs; United States National Institutes of Health; arterial stiffness; base; outcome forecast; prognostic indicator; psychologic

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Goals of Proposed Study: We hypothesize that EMS will result in a significant reduction in two prognostic indicators of HF, namely, minute ventilation (VE)/carbon dioxide production (VCO2) slope and brain natriutic peptide (BNP). We also hypothesize that cessation of EMS will result in reversal of positive physiologic adaptations. Additionally, EMS will result in a significant improvement in peak oxygen consumption (VO2) and VO2 at ventilatory threshold (VT) as well as significant improvement in perceived quality of life and functional capacity. SPECIFIC AIMS It has been shown that patients with moderate to severe chronic heart failure undergo significant increases in peak VO2, VO2 at VT and perceived quality of life following a five to eight week EMS training program. However, additional measures of prognosis in CHF patients have not been investigated following EMS. Furthermore, no investigations have assessed the impact cessation of EMS has on physiologic and psychological measures. The primary aims of the proposed study is to: 1. Determine the effect of a five week home based EMS training program on the VE/VCO2 slope, BNP level, peak VO2, VO2 at VT, perceived quality of life and perceived functional capacity in subjects diagnosed with CHF. 2. Examine changes in the previously outlined outcome measurements five weeks after cessation of the EMS training program.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 拟议研究的目标：我们假设 EMS 将导致心力衰竭的两个预后指标显着降低，即每分钟通气量 (VE)/二氧化碳产生量 (VCO2) 斜率和脑钠肽 (BNP)。 我们还假设停止 EMS 将导致积极的生理适应逆转。 此外，EMS 将显着改善峰值耗氧量 (VO2) 和通气阈值 (VT) 的 VO2，并显着改善感知生活质量和功能能力。 具体目标 研究表明，中度至重度慢性心力衰竭患者在接受五至八周的 EMS 训练计划后，峰值摄氧量、VT 摄氧量和感知生活质量显着增加。 然而，EMS 后尚未研究 CHF 患者预后的其他指标。 此外，没有调查评估停止 EMS 对生理和心理测量的影响。 拟议研究的主要目的是： 1. 确定为期五周的家庭 EMS 训练计划对 VE/VCO2 斜率、BNP 水平、峰值 VO2、VT VO2、感知生活质量和感知功能能力的影响被诊断患有 CHF 的受试者。 2. 在 EMS 培训计划停止五周后检查先前概述的结果测量的变化。