PROGNOSTIC VALUE OF CLINICAL EXERCISE TESTING WITH VENTILATORY EXPIRED GAS

通气呼出气体临床运动测试的预后价值

• 批准号: 7375138
• 负责人: ROSS A ARENA
• 金额: $ 0.28万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375138
• 关键词: PROGNOSTIC; VALUE; CLINICAL; EXERCISE; TESTING

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Symptom-limited exercise testing with ventilatory expired gas is an accepted form of evaluation in the heart failure population. There are a number of parameters, beyond peak VO2, which appear to hold clinical value. The purpose of this study is to improve the interpretive skills of clinicians responsible for analysis of this type of data and to apply it in a way that is beneficial to the care of the patient with heart failure, and to prospectively build a database of key variables from standard of care exercise tests in patients with HF and simultaneously assess their individual and combined ability to predict cardiac related hospitalization and mortality over a one-year period. The value of exercise testing in the heart failure (HF) population is well established. Guidelines for exercise testing put forth be the American College of Cardiology and American Heart Association categorize exercise testing with ventilatory expired gas analysis in the HF population as a class I recommendation which is based upon a large number of well controlled investigations supporting its use. To date, there has not been an investigation, which has compared the prognostic significance of all promising ventilatory expired gas parameters simultaneously. Additionally, little work has been done in examining the ability of these parameters to predict outcomes other than mortality. Given that HF is the primary hospital diagnostic related group among Medicare patients, analysis of measures predicting hospitalization in this population seems warranted. Subjects are required to participate in an exercise test with ventilatory expired gas analysis as part of their standard of care as determined by their cardiologist/physician. The session consists of collecting necessary background information, completing all paperwork and written evaluation tools, and undergoing a symptom-limited exercise test. These procedures are identical to what would be performed clinically without a research agenda. The only addition will be the construction of a database to determine the prognostic ability of exercise testing data.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。通风过期气体的症状受限运动测试是心力衰竭人群中公认的评估形式。除峰值VO2之外，还有许多参数似乎具有临床价值。这项研究的目的是提高负责分析此类数据的临床医生的解释能力，并以一种有益于心力衰竭患者的护理的方式应用，并前瞻性地构建了HF患者的关键变量数据库的数据库，并同时评估其个人和相关的相关住院和抵押术的能力。 运动测试在心力衰竭（HF）人群中的价值已经确定。锻炼测试的指南是美国心脏病学和美国心脏协会，将运动测试与HF人群中的通风过期的气体分析分类为I类建议，该建议是基于大量支持其使用的良好控制的调查。迄今为止，还没有进行调查，该研究比较了所有有前途的通气过期气体参数的预后意义。此外，在检查这些参数预测死亡率以外的结果的能力方面几乎没有做出的工作。鉴于HF是Medicare患者的主要医院诊断相关组，因此对预测该人群住院的措施的分析似乎是必要的。 受试者必须参加通风过期的气体分析，作为其心脏病专家/医师确定的护理标准的一部分。该会议包括收集必要的背景信息，完成所有文书工作和书面评估工具，并进行症状有限的运动测试。这些程序与没有研究议程的情况下在临床上进行的操作相同。唯一的添加是构建数据库，以确定运动测试数据的预后能力。