CLINICAL TRIAL: A DOUBLE-BLIND, RANDOMIZED, CONTROLLED PHASE III STUDY TO ASSESS

临床试验：双盲、随机、对照 III 期研究进行评估

• 批准号: 7716566
• 负责人: Gregory James Mertz
• 金额: $ 17.4万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716566
• 关键词: Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Disease; Double-Blind Method; Frequencies; Funding; Genital system; Grant; Herpesvirus 1; Human Herpesvirus 2; Immune; Infection; Institution; Phase; Randomized; Recurrence; Research; Research Personnel; Resources; Simplexvirus; Source; United States National Institutes of Health; Vaccines; Woman; aluminum sulfate; genital herpes; prevent

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objective of this study is to determine whether gDt-alum-MPL vaccine protects women who are HSV-1 (herpes simplex virus) and HSV-2 negative against genital herpes caused disease caused by either HSV1 or HSV2. The secondary objectives are to (a) determine whether gDt-alum-MPL vaccine prevents HSV-1 and HSV-2 negative women from acquiring HSV1 or HSV2 infection, reduces HSV shedding following HSV-2 seroconversion, reduces the frequency of recurrent genital herpes disease, or prevents oro-labial disease, and (b) to assess potential correlates of immune protection for HSV-2 genital disease and HSV-2 infection.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究的主要目的是确定GDT-ALUM-MPL疫苗是否保护HSV-1（单纯疱疹病毒）和HSV-2阴性的女性是否针对HSV1或HSV2引起的疾病引起的HSV-2阴性。次要目标是（a）确定GDT-ALUM-MPL疫苗是否可以防止HSV-1和HSV-2负妇女获得HSV1或HSV2感染，从而减少HSV-2血清转化后HSV脱落，可减少对复发性疱疹疾病的频率，或者降低了抗性疾病的频率，或评估型疾病，或者provestion protist ofer-labial疾病，或者降低了hsv-labial疾病，以及（b）的疾病，以及（b）的疾病，（b），或者降低了hsv-nime protistion-oro-labial疾病，（b）的疾病，以及（b）的疾病，（b）疾病。生殖器疾病和HSV-2感染。