HANTAVIRUS ECOLOGY AND DISEASE IN CHILE

智利的汉坦病毒生态和疾病

• 批准号: 6928199
• 负责人: Gregory James Mertz
• 金额: $ 100.57万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6928199
• 关键词: Hantavirus; cooperative study; disease outbreaks; Hantavirus; cooperative study; disease outbreaks

Hantavirus cardiopulmonary syndrome (HCPS) is an acute viral infection with a 50% case-fatality that was first recognized in 1993 in New Mexico. Wild rodents transmit it to man. Both North and South America have experienced outbreaks and sporadic cases of HCPS, with 500 cases now recognized. University of New Mexico (UNM) faculty are leaders in the study of HCPS and its ecology, diagnosis, molecular biology, vaccine development, treatment, and pathogenesis. They have traveled to 5 countries in South America, Europe, Israel and Australia to teach courses and conduct workshops, and several have served on NIH and CDC committees on HCPS. UNM currently holds more than $1 million/year in direct costs in federal grants that are directed solely in hantavirus research, as well as other large grants with a hantavirus component. This application describes an International Collaboration in Infectious Diseases Research (ICIDR) program for hantavirus research that matches UNM expertise and resources with similar impressive expertise and resources in Chile. Chilean collaborators are in Santiago at the federal Ministry of Health, including its laboratory branch, the Institute of Public Health (ISP); at Catholic University and University of Chile; and at regional hospitals in Coyhaique and Temuco, two of the primary sites at which HCPS patients are treated. Highly qualified and well-trained collaborators have been identified at all sites. The Ministry of Health rapidly developed resources and manpower to address the HCPS outbreaks, which were first recognized only in August 1997. They have constructed a new laboratory for biological containment work involving the very dangerous Andes hantavirus strain at the ISP and have secured a steady funding stream of $600,000/year from the federal government solely for hantavirus prevention and treatment. Most of these monies can be considered matching funds for the present application. The application involves 4 very strongly linked projects on the ecology of hantaviruses in wild rodents, the interpersonal transmission of HCPS, the genetic basis for severe HCPS and the treatment of HCPS. Two other US universities also provide specific research expertise. Each project pairs strong US technology and experience with highly motivated and experienced Chilean collaborators. Each project has clear and achievable specific aims that will advance the field considerably. A major goal of each project is the rapid and early transfer of technology to Chile to advance scientific knowledge about HCPS for the mutual benefit of both Chilean and US public health. The projects will foster Chilean science well beyond the hantavirus research arena. This ICIDR application is uniquely situated to produce a tremendous return in scientific knowledge because of the substantial cost-matching in Chile and the US and because there is currently relatively little knowledge regarding hantavirus ecology, transmission, disease causation, and treatment.

汉坦病毒心肺综合征（HCPS）是一种急性病毒感染，患有50％的病例效果，于1993年在新墨西哥州首次被识别。野生啮齿动物将其传递给人。北美和南美都经历了HCP的爆发和零星病例，现在有500例案件已确认。新墨西哥大学（UNM）是HCPS研究及其生态，诊断，分子生物学，疫苗发育，治疗和发病机理的领导者。他们已经前往南美，欧洲，以色列和澳大利亚的5个国家，教授课程和举办研讨会，其中一些人在NIH和CDC委员会曾在HCP上任职。 UNM目前仅针对仅针对汉塔病毒研究的联邦补助金以及其他具有汉坦病毒组件的大笔赠款，持有超过100万美元的直接费用。该应用程序介绍了针对汉塔病毒研究的国际传染病研究（ICIDR）计划，该计划与智利具有类似令人印象深刻的专业知识和资源的INM专业知识和资源相匹配。智利合作者在联邦卫生部的圣地亚哥，包括其实验室分支，公共卫生研究所（ISP）；在天主教大学和智利大学；在Coyhaique和Temuco的区域医院，对HCPS患者进行治疗的两个主要部位。在所有网站上都确定了高素质和训练有素的合作者。卫生部迅速开发了解决HCP爆发的资源和人力，该爆发仅在1997年8月才被确认。他们为ISP构建了一项新的生物遏制工作实验室，用于ISP的非常危险的安第斯山脉Hantavirus Strain，并获得了联邦政府为Hantavirus Pervicent和Hantavirus Pervicent and Bearthered of Federal Guardment of Federal Groundmity的稳定资金。这些款项中的大多数可以被视为本申请的匹配资金。该应用涉及4个关于野生啮齿动物中汉坦病毒生态学的非常紧密联系的项目，HCP的人际传播，严重HCP的遗传基础和HCP的治疗。其他两所美国大学也提供特定的研究专业知识。每个项目都将强大的美国技术与高度积极进取和经验丰富的智利合作者配对。每个项目都有明确且可实现的特定目标，可以大大推动整个领域。每个项目的一个主要目标是将技术迅速转移到智利，以促进有关HCP的科学知识，以促进智利和美国公共卫生的相互利益。这些项目将促进智利科学远远超出汉塔病毒研究领域。由于智利和美国的成本匹配，因此这种ICIDR应用是在科学知识中产生巨大回报的独特所在，并且因为目前关于汉塔病毒生态学，传播，疾病因果关系和治疗的知识相对较少。