Postdoctoral Training in the Hantavirus Project Ecology

汉坦病毒项目生态学博士后培训

• 批准号: 6851317
• 负责人: Gregory James Mertz
• 金额: $ 5万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-22 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6851317
• 关键词: Hantavirus; South America; clinical research; postdoctoral investigator; training

DESCRIPTION (provided by applicant): The objectives of this application are to train and expand the capabilities of a post doctoral scientist from Chile. The aims of the post doctoral scientist are to test the hypothesis that seropositive O. longicaudatus are more concentrated in the Mediterranean than in the Temperate Forests, because the species has a more patchy distribution in central Chile. This patchy distribution pattern in the Mediterranean region is due to the ecological characteristics of the landscape; primarily central Chile is drier with less of the preferred mesic habitat required by the reservoir species. A patchy distribution would restrict movement of individuals among populations (i.e., gene flow) and create greater geographic structure among populations. This concentrated, patchy distribution would also induce a higher contact rate within the localized populations of the more mesic areas. This pattern should be reflected at the molecular level as populations should be more genetically structured in the northern range of the species, in contrast to populations of the Temperate Forests in southern Chile. Furthermore, the training plan will provide an assessment of the degree of intra and interpopulational gene flow as a function of geographical distance among the two major eco-regions in Chile, as well as a function of latitude (hence climate). Post doctoral scientist will gain expertise in laboratory techniques, analyses and theory related to molecular population genetics and evolution in the combined laboratories of Drs. Cook and Yates at the University of New Mexico. A close working relationship with the virology laboratory of Dr. Brian Hjelle will provide a key connection to the ongoing quantitative viral RTPCR (TaqMan)studies of these reservoir populations.

描述（由申请人提供）：本申请的目标是训练和扩大智利博士后科学家的能力。博士后科学家的目的是检验以下假设：朗西多塔斯在地中海中比温带森林更集中在地中海，因为该物种在辣椒中部的分布更宽。地中海地区的这种零散的分布模式是由于景观的生态特征所致。主要是智利中央智利的干燥，而水库物种要求的首选中居栖息地较少。零散的分布将限制个人在人群中的运动（即基因流），并在人群之间创造更大的地理结构。这种浓缩的分布还将在更近乎介质的地区的局部人群中引起更高的接触率。这种模式应在分子水平上反映，因为与智利南部温带森林的种群相比，种群应在该物种的北部范围内更具遗传结构。此外，培训计划将对内部和人口间的程度进行评估 基因流量是智利两个主要生态区域之间地理距离的函数，以及纬度的函数（因此气候）。博士后科学家将获得与DRS联合实验室中的分子种群遗传学和进化有关的实验室技术，分析和理论的专业知识。新墨西哥大学的库克和耶茨。与Brian Hjelle博士的病毒学实验室建立密切的工作关系，将为这些储层人群的持续定量病毒RTPCR（TAQMAN）研究提供关键联系。