HUMAN REQUIREMENTS FOR THE NUTRIENT CHOLINE

人体对营养胆碱的需求

• 批准号: 7716848
• 负责人: Steven H Zeisel
• 金额: $ 9.7万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-02 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716848
• 关键词: Affect; Cell membrane; Choline; Cholinergic Agents; Computer Retrieval of Information on Scientific Projects Database; Diet; Estrogens; Funding; Genetic Polymorphism; Grant; Human; Individual; Institution; Metabolism; Nutrient; Nutritional Requirements; Research; Research Personnel; Resources; Signal Transduction; Source; United States National Institutes of Health; Variant; cholinergic; dietary requirement; lipid transport; methyl group; neurotransmission

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Choline is a dietary nutrient essential for the structural integrity and signaling functions of cell membranes; it is the major source of methyl-groups in the diet, and it directly affects cholinergic neurotransmission, transmembrance signaling and lipid transport/metabolism. The major premise for this proposal is that humans require a dietary source of choline and that this requirement has significant individual variation. The investigators suggest that estrogen and common genetic polymorphisms modulate this dietary requirement for choline.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 胆碱是一种膳食营养素，对于细胞膜的结构完整性和信号传导功能至关重要；它是饮食中甲基的主要来源，直接影响胆碱能神经传递、跨膜信号传导和脂质转运/代谢。 该提议的主要前提是人类需要胆碱的饮食来源，并且这种需求具有显着的个体差异。 研究人员认为，雌激素和常见的基因多态性调节了这种对胆碱的饮食需求。