HCV CENTER STUDIES ON INFECTIOUS HCV

HCV 中心关于传染性 HCV 的研究

• 批准号: 7716082
• 负责人: Robert E LANFORD
• 金额: $ 0.39万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716082
• 关键词: Antiviral Agents; Chronic; Cirrhosis; Computer Retrieval of Information on Scientific Projects Database; Development; Funding; Goals; Grant; Hepatitis C; Hepatitis C virus; Individual; Infection; Infectious hepatitides; Institution; Liver diseases; Malignant neoplasm of liver; Molecular; Molecular Cloning; Pan Genus; Pan troglodytes; Population; Research; Research Personnel; Resources; Ribavirin; Source; Testing; United States National Institutes of Health; Vaccines; Viral; improved; interferon therapy; tissue culture

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Approximately 2% of the US population in chronically infected with hepatitis C virus (HCV). Chronic HCV infections result in significant liver disease including cirrhosis and liver cancer in approximately 20%of infected individuals. The current therapy of interferon and ribavirin does not result in viral clearance in the majority of cases. A better understanding of the replication of HCV at a molecular level as well as the factors that determine whether an infection will proceed to chronic infection or viral clearance are essential for the development of improved antiviral strategies. These studies are important for both vaccine and antiviral development. This is subcontract from the SOUTHEASTERN COOPERATIVE HEPATTIS C RESEARCH GROUP (0024). The goal was to test a molecular clone of HCV that replicates in tissue culture for replication in chimpanzees.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 长期感染丙型肝炎病毒（HCV）的美国人群约有2％。 慢性HCV感染导致大约20％的受感染个体的肝硬化和肝癌，包括肝硬化和肝癌。 在大多数情况下，干扰素和利巴韦林的当前疗法不会导致病毒清除。 更好地了解分子水平上的HCV的复制，以及决定感染是否会继续进行慢性感染或病毒清除的因素对于发展改善的抗病毒药策略至关重要。 这些研究对于疫苗和抗病毒发育都很重要。 这是从东南合作社Hepattis C研究小组（0024）的分包合同。目的是测试HCV的分子克隆，该克隆在组织培养中复制以在黑猩猩中复制。