NIH-Owned Chimpanzee Research Resource at the SNPRC

NIH 拥有的 SNPRC 黑猩猩研究资源

• 批准号: 8727694
• 负责人: Robert E LANFORD
• 金额: --
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-05 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8727694
• 关键词: Acquired Immunodeficiency Syndrome; Animals; Biochemical; Biomedical Research; Caring; Characteristics; Clinical; Cognition; Communicable Diseases; Communities; Complex; Data; Databases; Disease; Evolution; Experimental Designs; Future; Genes; Genetic; Genomics; HIV; Health; Health Status; Heart Diseases; Hepatitis; Hepatitis B Virus; Hepatitis C virus; Human; Human immunodeficiency virus test; Individual; Infection; Liver; Measures; Messenger RNA; MicroRNAs; Modeling; National Center for Research Resources; Pan Genus; Peripheral Blood Mononuclear Cell; Pharmaceutical Preparations; Physiological; Physiology; Play; Pongidae; Population; Prevention; Primates; Recording of previous events; Relative (related person); Research; Research Personnel; Research Subjects; Resources; Role; Sampling; Schedule; Testing; Time; United States National Institutes of Health; Variant; cohort; design; efficacy testing; genome sequencing; humanized monoclonal antibodies; infectious disease treatment; man; novel therapeutic intervention; programs; public education; safety testing; transcriptome sequencing

DESCRIPTION (provided by applicant): The genetic, physiological, biochemical, and immunological similarities of chimpanzees to humans make them unique models for biomedical research directed at many aspects of human health including, among others, developing preventions and treatments for infectious diseases (e.g., HBV, HCV, HIV), testing the effects of drugs specifically designed for use in humans, and testing the safety and efficacy of humanized monoclonal antibodies. The overall objective of this project is to maintain an NCRR-owned research resource consisting of 209 chimpanzees and to manage it to serve the national biomedical research needs. We will pursue the following specific aims: 1) To maintain a stable, healthy, well defined population of chimpanzees and to make them available for research; 2) To maintain a cohort of well characterized chimpanzees persistently infected with HBV, HCV or HIV for research on hepatitis and AIDS and for testing the efficacy of new therapeutic approaches; 3) To develop a unique resource of fully sequenced transcriptomes from liver samples of all 209 chimpanzees, including mRNAs and microRNAs, and from PBMC samples of a subset of 36 chimpanzees that are chronically infected with HCV or that have cleared the infection; 4) To develop longitudinal quantitative measures of physiological characteristics that are of importance to biomedical research and to analyze them in relation to sequence data from Aim 3 and in relation to health status; 5) To develop a data base that contains information about the chimpanzees and the data obtained under Aims 3 and 4, and to make it available to the national biomedical research community for research purposes and for selection of experimental subjects; 6) To establish a program for educating the public as to the importance of chimpanzees in biomedical research. Via fulfilling these aims, we will establish a chimpanzee resource that is unique among all chimpanzee research resources in enabling investigators for the first time to exploit genome sequence data from individual chimpanzees in experimental design and in genomic analyses. In addition, the educational program will contribute to the public's understanding of the care and use of chimpanzees in biomedical research, and the need for resources such as the one proposed in this application.

描述（由申请人提供）：黑猩猩与人类的遗传，生理，生化和免疫学相似性使它们成为针对人类健康许多方面的生物医学研究模型的独特模型，包括开发针对感染性疾病的预防和治疗方法（例如HBV，HCV，HIV，HIV，HIV），特定于药物的效果，并具有特定的效果。人源化的单克隆抗体。该项目的总体目的是维持由209个黑猩猩组成的NCRR拥有的研究资源，并管理它以满足国家生物医学研究需求。我们将追求以下具体目标：1）维持稳定，健康，定义明确的黑猩猩人群，并使其可用于研究； 2）维持一系列具有HBV，HCV或HIV感染的黑猩猩，以进行肝炎和艾滋病研究，并测试新的治疗方法的功效； 3）从所有209种黑猩猩（包括mRNA和microRNA）的肝脏样品中开发出独特的测序转录组，以及从长期感染HCV或已清除感染的36个黑猩猩的pBMC样品中的独特资源； 4）开发生物医学研究至关重要的生理特征的纵向定量测量，并根据AIM 3和与健康状况有关的序列数据进行分析； 5）开发一个数据库，其中包含有关黑猩猩和目标3和4获得的数据的信息，并使国家生物医学研究社区可用于研究目的和选择实验学科； 6）建立一个计划，以教育公众关于黑猩猩在生物医学研究中的重要性。通过实现这些目标，我们将建立一种黑猩猩资源，在所有黑猩猩研究资源中都是独一无二的，这是使研究人员首次能够从实验设计和基因组分析中利用单个黑猩猩的基因组序列数据。此外，教育计划将有助于公众对黑猩猩在生物医学研究中的护理和使用以及对资源（例如本申请中提出的资源）的需求。